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Title:Nrf2-interacting nutrients and COVID-19 : time for research to develop adaptation strategies
Authors:Bousquet, Jean (Author)
Cristol, Jean-Paul (Author)
Czarlewski, Wienczyslawa (Author)
Antò i Boquè, Josep M. (Author)
Martineau, Adrian (Author)
Haahtela, Tari (Author)
Fonseca, Susana C. (Author)
Iaccarino, Guido (Author)
Blain, Hubert (Author)
Fiocchi, Alessandro (Author)
Bajrović, Nisera (Author)
Edelbaher, Natalija (Author)
Jošt, Maja (Author)
Kopač, Peter (Author)
Koren, Anja (Author)
Košnik, Mitja (Author)
Kramer Vrščaj, Karmen (Author)
Kreft, Samo (Author)
Lalek, Nika (Author)
Madjar, Bojan (Author)
Poplas-Susič, Tonka (Author)
Rozman Sinur, Irma (Author)
Soklič, Tanja (Author)
Triller Vadnal, Katja (Author)
Triller, Nadja (Author)
Urbančič, Jure (Author)
Zidarn, Mihaela (Author)
Tipology:1.02 - Review Article
Organisation:Logo UKPBAG - University Clinic of Respiratory and Allergic Diseases Golnik
Abstract:There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPAR[gamma]:Peroxisome proliferator-activated receptor, NF[kappa]B: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2[alpha]:Elongation initiation factor 2[alpha]). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT1R axis (AT1R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity.
Keywords:Covid-19, SARS-CoV-2, food, insulin resistance, obesity, Nrf2, nutrients, TRPA1
Year of publishing:2020
Publisher:Springer Nature
Source:Velika Britanija
COBISS_ID:47724291 Link is opened in a new window
ISSN on article:2045-7022
OceCobissID:31507929 Link is opened in a new window
DOI:10.1186/s13601-020-00362-7 Link is opened in a new window
Note:Nasl. z nasl. zaslona; Soavtorji iz Slovenije: Nissera Bajorvić, Natalija Edelbaher, Maja Jošt, Peter Kopač, Anja Koren Jeverica, Mitja Košnik, Karmer Kramer Vrščaj, Samo Kreft, Nika Lalek, Bojan Madjar, Antonija Poplas Susič, Irma Rozman Sinur, Tanja Soklič Košak, Katja Triller, Nadja Triller, Jure Urbancic, Mihaela Zidarn; Opis vira z dne 19. 1. 2021; Št. članka: 58;
Files:.pdf PDF - Presentation file, download (1,61 MB)
Journal:Clinical and translational allergy
BioMed Central
Rights:© The Author(s) 2020
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License:CC BY-NC 4.0, Creative Commons Attribution Non-Commercial 4.0 International
Description:A creative commons license that bans commercial use, but the users don’t have to license their derivative works on the same terms.
Licensing start date:03.12.2020