20.500.12556/DiRROS-13693 Nrf2-interacting nutrients and COVID-19 : time for research to develop adaptation strategies There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPAR[gamma]:Peroxisome proliferator-activated receptor, NF[kappa]B: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2[alpha]:Elongation initiation factor 2[alpha]). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT1R axis (AT1R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity. Covid-19 SARS-CoV-2 food insulin resistance obesity Nrf2 nutrients TRPA1 covid-19 SARS-CoV-2 hrana odpornost proti inzulinu debelost Nrf2 hranila TRPA1 true false true Springer Nature Angleški jezik Ni določen © The Author(s) 2020 Neznano 2021-01-25 14:34:16 2021-01-25 14:34:17 2022-08-19 03:36:07 0000-00-00 00:00:00 2020 0 Velika Britanija 0 Nasl. z nasl. zaslona; Soavtorji iz Slovenije: Nissera Bajorvić, Natalija Edelbaher, Maja Jošt, Peter Kopač, Anja Koren Jeverica, Mitja Košnik, Karmer Kramer Vrščaj, Samo Kreft, Nika Lalek, Bojan Madjar, Antonija Poplas Susič, Irma Rozman Sinur, Tanja Soklič Košak, Katja Triller, Nadja Triller, Jure Urbancic, Mihaela Zidarn; Opis vira z dne 19. 1. 2021; Št. članka: 58; str. 1-18 Vol. 10 Dec. 2020 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.9 2045-7022 10.1186/s13601-020-00362-7 47724291 31507929 s13601-020-00362-7.pdf s13601-020-00362-7.pdf 1 1E9460247354FAAF884D5E3BB39A06C5 7b5df45c77b68946829edf8ae29b0b8cac455a9933333bd08469b083b4a1ea8c 717d834a-17b6-11ed-b6b8-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=16721 Univerzitetna klinika za pljučne bolezni in alergijo Golnik 0 0 0