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Title:Important and specific role for basophils in acute allergic reactions
Authors:Korošec, Peter (Author)
Gibbs, Bernhard F. (Author)
Rijavec, Matija (Author)
Custovic, Adnan (Author)
Turner, Paul J. (Author)
Tipology:1.02 - Review Article
Organisation:Logo UKPBAG - University Clinic of Respiratory and Allergic Diseases Golnik
Abstract:IgE-mediated allergic reactions involve the activation of effector cells, predominantly through the high-affinity IgE receptor (FceRI) on mast cells and basophils. Although the mast cell is considered the major effector cell during acute allergic reactions, more recent studies indicate a potentially important and specific role for basophils and their migration which occurs rapidly upon allergen challenge in humans undergoing anaphylaxis. We review the evidence for a role of basophils in contributing to clinical symptoms of anaphylaxis, and discuss the possibility that basophil trafficking during anaphylaxis might be a pathogenic (to target organs) or protective (preventing degranulation in circulation) response. Finally, we examine the potential role of basophils in asthma exacerbations. Understanding the factors that regulate basophil trafficking and activation might lead to new diagnostic and therapeutic strategies in anaphylaxis and asthma.
Keywords:allergy and immunology, basophils, anaphylaxis
Year of publishing:2018
Publisher:John Wiley & Sons
Source:Velika Britanija
COBISS_ID:2048254577 Link is opened in a new window
ISSN on article:1365-2222
OceCobissID:515014681 Link is opened in a new window
DOI:10.1111/cea.13117 Link is opened in a new window
Note:Soavtorji: Bernhard F. Gibbs, Matija Rijavec, Adnan Custovic and Paul J. Turner; Nasl. z nasl. zaslona; Opis vira z dne 7. 3. 2018;
Files:.pdf PDF - Presentation file, download (511,01 KB)
URL URL - Source URL, visit
Journal:Clin. exp. allergy
Blackwell Science
Rights:© 2018 The Authors.
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License:CC BY 4.0, Creative Commons Attribution 4.0 International
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:12.02.2018