| Title: | Important and specific role for basophils in acute allergic reactions |
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| Authors: | ID Korošec, Peter, Klinika Golnik (Author)
ID Gibbs, Bernhard F. (Author)
ID Rijavec, Matija, Klinika Golnik (Author)
ID Custovic, Adnan (Author)
ID Turner, Paul J. (Author) |
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| Files: |  PDF - Presentation file, download (511,01 KB)
MD5: D14CB5AECABFAEC38A9203C1D6BC8680
 URL - Source URL, visit https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.13117
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| Language: | English |
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| Typology: | 1.02 - Review Article |
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| Organization: |  UKPBAG - University Clinic of Respiratory and Allergic Diseases Golnik
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| Abstract: | IgE-mediated allergic reactions involve the activation of effector cells, predominantly through the high-affinity IgE receptor (FceRI) on mast cells and basophils. Although the mast cell is considered the major effector cell during acute allergic reactions, more recent studies indicate a potentially important and specific role for basophils and their migration which occurs rapidly upon allergen challenge in humans undergoing anaphylaxis. We review the evidence for a role of basophils in contributing to clinical symptoms of anaphylaxis, and discuss the possibility that basophil trafficking during anaphylaxis might be a pathogenic (to target organs) or protective (preventing degranulation in circulation) response. Finally, we examine the potential role of basophils in asthma exacerbations. Understanding the factors that regulate basophil trafficking and activation might lead to new diagnostic and therapeutic strategies in anaphylaxis and asthma. |
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| Keywords: | allergy and immunology, basophils, anaphylaxis |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Place of publishing: | Velika Britanija |
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| Publisher: | John Wiley & Sons |
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| Year of publishing: | 2018 |
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| Number of pages: | str. 502-512 |
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| Numbering: | Vol. 48, iss. 5 |
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| PID: | 20.500.12556/DiRROS-12902  |
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| UDC: | 616-097 |
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| ISSN on article: | 1365-2222 |
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| DOI: | 10.1111/cea.13117 |
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| COBISS.SI-ID: | 2048254577 |
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| Copyright: | © 2018 The Authors. |
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| Note: | Soavtorji: Bernhard F. Gibbs, Matija Rijavec, Adnan Custovic and Paul J. Turner;
Nasl. z nasl. zaslona;
Opis vira z dne 7. 3. 2018;
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| Publication date in DiRROS: | 14.12.2020 |
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| Views: | 1226 |
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| Downloads: | 807 |
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