1. Dopolnjena priporočila za obravnavo bolnikov z melanomom kožeMartina Reberšek, Janja Ocvirk, Primož Strojan, Marko Hočevar, Tanja Mesti, Barbara Perić, Katarina Šmuc Berger, Laura Đorđević Betetto, Vesna Zadnik, Olga Blatnik, Boštjan Luzar, Jože Pižem, Nežka Hribernik, Gaber Plavc, Marko Kokalj, Katarina Barbara Karner, Katarina Zevnik, Maja Marolt-Mušič, Nada Rotovnik-Kozjek, Karla Berlec, Maja Ebert Moltara, Jernej Benedik, Nataša Puzić Ravnjak, 2026, dictionary, encyclopaedia, lexicon, manual, atlas, map Keywords: koža, rak (medicina), zaščitni ukrepi, dejavniki tveganja, klinična diagnostika, stadij, prognoza, histopatologija, kirurško zdravljenje, radioterapija, sistemsko zdravljenje, sledenje pacientov, prehranska podpora, paliativna oskrba, elektronske knjige
Published in DiRROS: 07.08.2026; Views: 110; Downloads: 62
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2. Influence of nutritional status and body composition on postoperative events and outcome in patients treated for primary localized retroperitoneal sarcomaManuel Ramanović, Marko Novak, Andraž Perhavec, Taja Jordan, Karteek Popuri, Nada Rotovnik-Kozjek, 2024, original scientific article Abstract: Background: Retroperitoneal sarcomas (RPS) are rare tumours of mesenchymal origin, commonly presented as a large tumour mass at time of diagnosis. We investigated the impact of body composition on outcome in patients operated on for primary localized RPS. Patients and methods: We retrospectively analysed data for all patients operated on for primary RPS at our institution between 1999 and 2020. Preoperative skeletal muscle area (SMA), visceral and subcutaneous adipose tissue area (VAT and SAT) and muscle radiation attenuation (MRA) were calculated using computed tomography scans at the level of third lumbar vertebra. European Working Group on Sarcopenia in Older People (EWGSOP2) criteria were applied to define myopenia. Using maximum log-rank statistic method we determined the optimal cut-off values of body composition parameters. Myosteatosis was defined based on determined MRA cut-offs. Results: In total 58 patient were eligible for the study. With a median follow-up of 116 months, the estimated 5-year overall survival (OS) and local-recurrence free survival (LRFS) were 66.8% and 77.6%, respectively. Patients with myopenia had significantly lower 5-year OS compared to non-myopenic (p = 0.009). Skeletal muscle index and subcutaneous adipose tissue index predicted LRFS on univariate analysis (p = 0.052 and p = 0.039, respectively). In multivariate analysis high visceral-to-subcutaneous adipose tissue area ratio (VSR) independently predicted higher postoperative complication rate (89.2% vs. 10.8%, p = 0.008). Myosteatosis was associated with higher postoperative morbidity. Conclusions: Myopenia affected survival, but not postoperative outcome in RPS. Visceral obesity, VSR (> 0.26) and myosteatosis were associated with higher postoperative morbidity. VSR was better prognostic factor than VAT in RPS.
Keywords: body composition, cancer cachexia, obesity
Published in DiRROS: 26.06.2026; Views: 176; Downloads: 151
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3. Impaired booster-induced SARS-CoV-2 antibody responses in rituximab-treated B-cell lymphoma patients despite peripheral B-Cell RecoveryTomaž Jurca, Lučka Boltežar, Miha Oražem, Kristina Fujs Komloš, Katka Pohar, Sara Jevnikar, Mario Poljak, Denis Mlakar-Mastnak, Nada Rotovnik-Kozjek, Bor Vratanar, Janja Ocvirk, Alojz Ihan, 2026, original scientific article Abstract: Rituximab-treated patients with B-cell lymphoma exhibit profound B-cell depletion and impaired vaccine-induced antibody responses. However, it remains uncertain whether recovery of peripheral B-cell counts after rituximab is sufficient to restore effective humoral immunity following booster vaccination. Patients and methods In this prospective, single-center observational study at the Institute of Oncology Ljubljana, adult B-cell lymphoma patients treated with or previously exposed to rituximab received the Comirnaty® mRNA COVID-19 vaccine. Antibody responses to the SARS-CoV-2 spike and nucleoprotein were measured at baseline, 14 days after the second dose, and at 3, 6, 9, and 12 months. A third dose was administered at 6 months. T-cell responses (IFN-γ release) were assessed in patients before and after the primary series and booster dose. Lymphocyte subsets were analysed pre-vaccination. Adverse events and nutritional status were monitored. Results Patients undergoing anti-CD20 therapy showed absent antibody responses. Longer intervals since rituximab correlated with peripheral B-cell repopulation. However, even after reaching normal B-cell counts, patients’ antibody responses after revaccination remained significantly lower than in controls. Conclusions Rituximab is associated with impaired vaccine-induced antibody responses. Despite recovery of peripheral B-cell counts, patients with B-cell lymphoma show reduced humoral responses compared with healthy individuals following booster COVID-19 vaccination.
Keywords: lymphoma, B-cell, rituximab, COVID-19 vaccines
Published in DiRROS: 03.06.2026; Views: 334; Downloads: 119
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4. Is there a place for ultrasound in diagnosing sarcopenia?Tadej Rondaij, Nada Rotovnik-Kozjek, Cene Jerele, Taja Jordan, 2025, review article Abstract: Sarcopenia is a progressive and generalised skeletal muscle disorder which presents as loss of muscle mass and function and is associated with increased likelihood of adverse outcomes, reduced quality of life and increased mortality. In developed countries, the prevalence of sarcopenia is rising due to increasing life expectancy. Still, in many clinical settings, sarcopenia may be overlooked and undertreated. While several tools are available for assessment of muscle mass and quality, there remains a need for safe, reliable and accurate diagnostic methods which can be implemented for both sarcopenia diagnosis and the evaluation of treatment efficacy.
Keywords: sarcopenia, ultrasonography, muscle mass
Published in DiRROS: 22.04.2026; Views: 312; Downloads: 95
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5. Telesna dejavnost, mišica in klinična prehranaNada Rotovnik-Kozjek, Gašper Tonin, 2025, professional article Abstract: Telesna dejavnost in prehrana sta neločljivo povezani pri vzdrževanju mišičnega in splošnega zdravja, presnovne odpor-nosti ter preprečevanju s staranjem pogojene izgube mišičnine. Vadba predstavlja močan fiziološki stresni dejavnik, ki akutno sproži presnovne, endokrine in imunske odzive, kar predstavlja velik izziv za homeostazo. Za lažje obvladovanje tega stresa se ob redni vadbi v telesu pojavijo številne presnovne prilagoditve, ki ga poskušajo zmanjšati. Presnovne spremembe, ki ji sproži telesna vadba, vključujejo povečano energijsko potrebo, prila-goditev uporabe presnovnih goriv in hormonska nihanja. Redna telesna vadba vodi do strukturnih in funkcionalnih prilagoditev na mišični, srčno-žilni in celotni telesni ravni. Pravilne pre-hranske strategije, usklajene z vrsto, intenzivnostjo in trajanjem dejavnosti, zagotavljajo potrebne substrate za delo, optimizirajo regeneracijo, spodbujajo sintezo mišičnih beljakovin in krepijo imunski odziv. To ne izboljšuje le športne zmogljivosti, temveč tudi pomembno prispeva k zdravstvenim učinkom vadbe, med katerimi so preprečevanje in obvladovanje številnih kroničnih bolezni, vključno z nekaterimi oblikami raka. Ker so te zdravstve-ne koristi bistvene tudi pri zdravljenju raka, pridobiva pozna-vanje načel in uporabe klinične športne prehrane velik pomen v onkologiji. Integracija znanj s področja vadbene fiziologije, presnovne podpore in prehranske terapije omogoča učinkovitejše ohranjanje mišične mase, zmanjševanje presnovnih zapletov ter izboljšanje odziva na zdravljenje. Uveljavljanje pristopa klinične športne prehrane v onkološki praksi tako predstavlja pomemben korak k celostnemu zdravljenju bolnika, ki temelji na znanstvenih dokazih in interdisciplinarnem sodelovanju.
Keywords: genetsko testiranje, dednost, ogroženost za raka
Published in DiRROS: 21.01.2026; Views: 526; Downloads: 234
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8. Priporočila za obravnavo bolnikov z melanomom kožeMartina Reberšek, Janja Ocvirk, Primož Strojan, Barbara Perić, Marko Hočevar, Katarina Šmuc Berger, Vesna Zadnik, Olga Blatnik, Katarina Zevnik, Nina Boc, Nežka Hribernik, Tanja Mesti, Karla Berlec, Nada Rotovnik-Kozjek, Maja Ebert Moltara, Jernej Benedik, Boštjan Luzar, Jože Pižem, Marko Boc, Marija Ignjatović, Katarina Barbara Karner, Gaber Plavc, Marko Kokalj, Marko Snoj, Katarina Trčko, 2024, professional article Keywords: koža, rak (medicina), zaščitni ukrepi, dejavniki tveganja, klinična diagnostika, stadij, prognoza, histopatologija, kirurško zdravljenje, radioterapija, sistemsko zdravljenje, sledenje pacientov, prehranska podpora, paliativna oskrba, elektronske knjige
Published in DiRROS: 21.05.2025; Views: 1038; Downloads: 717
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9. Parenteralna prehrana na domu po onkološkem zdravljenju ginekoloških rakovNada Rotovnik-Kozjek, Mia Majerr, Nizra Palamar, Laura Petrica, Tatjana Slapar, Gregor Vivod, Denis Mlakar-Mastnak, 2024, published scientific conference contribution Keywords: ginekološki raki, parenteralna prehrana, raki rodil
Published in DiRROS: 06.09.2024; Views: 1437; Downloads: 756
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10. Phase angle as a prognostic indicator of surgical outcomes in patients with gastrointestinal cancerJana Gulin, Ester Ipavic, Denis Mlakar-Mastnak, Erik Brecelj, Ibrahim Edhemović, Nada Rotovnik-Kozjek, 2023, original scientific article Keywords: phase angle, colorectal cancer, postoperative complications, malnutrition
Published in DiRROS: 26.07.2024; Views: 1827; Downloads: 465
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