251. Vpliv epidemije covid-19 na diagnostiko in zdravljenje rakaVesna Zadnik, Ana Mihor, Sonja Tomšič, Tina Žagar, Nika Bric, Katarina Lokar, 2020, published professional conference contribution Keywords: obvladovanje raka, covid-19, javno zdravje Published in DiRROS: 07.04.2021; Views: 1365; Downloads: 358 Full text (148,08 KB) |
252. CRP projekt : vpliv epidemije covid-19 na obvladovanje raka v SlovenijiTina Žagar, Sonja Tomšič, Mario Fafangel, Mateja Krajc, Ana Mihor, Vesna Zadnik, 2020, published professional conference contribution Keywords: obvladovanje raka, covid-19, javno zdravje Published in DiRROS: 07.04.2021; Views: 1084; Downloads: 314 Full text (99,24 KB) |
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254. Navodila za izvajanje programa Zora : državni program Zgodnjega Odkrivanja predRAkavih sprememb materničnega vratu (Zora)Marjetka Uršič-Vrščaj, Maja Primic-Žakelj, Irena Kirar-Fazarinc, Ana Pogačnik, Dunja Obersnel Kveder, 2003, dictionary, encyclopaedia, lexicon, manual, atlas, map Published in DiRROS: 24.03.2021; Views: 1037; Downloads: 378 Full text (1,84 MB) |
255. Drought stress can induce the pathogenicity of Cryptostroma corticale, the causal agent of sooty bark disease of sycamore mapleNikica Ogris, Ana Brglez, Barbara Piškur, 2021, original scientific article Abstract: Reports of sooty bark disease of maples caused by the fungus Cryptostroma corticale have recently been emerging from across Europe. The aims of our study were to describe the first report of sooty bark disease in Slovenia, to determine the pathogenicity of C. corticale, to confirm the optimum temperature for the growth of the fungus, and to determine the mass loss of Acer pseudoplatanus wood inoculated by C. corticale. We confirmed the presence of C. corticale on A. pseudoplatanus via morphological and molecular analysis. The optimal growth of C. corticale was measured in vitro on potato dextrose agar and was determined to occur at 25 °C. Pathogenicity tests were performed on 30 saplings of A. pseudoplatanus under two treatments, humid and drought stress, and the fungus was pathogenic in both treatments. The mean length of bark lesions and wood discoloration of the drought-stressed saplings was significantly greater than that in the humid treatment. Re-isolations of C. corticale were successful from all inoculated saplings, and thus Koch%s postulates were confirmed. The mass loss of A. pseudoplatanus wood was determined by mini-block test in a period of 10 weeks and was observed as minimal. Based on the results, we conclude that C. corticale is a weak and opportunistic pathogen that most likely expresses itself intensively under hot and dry conditions. Keywords: pathogenicity, drought stress, optimal growth, climate change, mass loss, mini-block test, wood rot, opportunistic pathogen, saprophyte, endophyte Published in DiRROS: 23.03.2021; Views: 1163; Downloads: 877 Full text (3,21 MB) This document has many files! More... |
256. Priročnik za fenološka opazovanja dreves v mestu in urbanih gozdovihUrša Vilhar, 2014, dictionary, encyclopaedia, lexicon, manual, atlas, map Keywords: fenologija, urbani gozdovi, monitoring, drevnine, drevesa, priročniki Published in DiRROS: 01.02.2021; Views: 1412; Downloads: 473 Full text (1,17 MB) |
257. Chemokines during anaphylaxis : the importance of CCL2 and CCL2-dependent chemotactic activity for basophilsRomana Vantur, Maruša Rihar, Ana Koren, Matija Rijavec, Peter Kopač, Urška Bidovec, Renato Eržen, Peter Korošec, 2020, original scientific article Abstract: Background: The role of chemokines in anaphylaxis is unclear. Methods: We prospectively recruited 49 patients presenting to the emergency department with an acute episode of anaphylaxis and 28 healthy subjects. We measured serum levels of the chemokines CCL2, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL21, CCL22, CCL24, and CCL26, tryptase, the absolute number of circulating basophils, monocytes, lymphocytes, and PMNs, and whole blood FCER1A, CPA3 and HDC gene expression at two time points: during the anaphylactic episode and in convalescent samples collected approximately 3 months later. We then investigated the in vitro chemotactic activity of chemokines induced during anaphylaxis for the in vitro migration of the corresponding cells. Results: Only CCL2 chemokine levels were signifcantly increased in anaphylaxis samples (median 514 pg/ml) compared to convalescent samples (284 pg/ml, P<0.0001) and healthy subjects (279 pg/ml, P<0.0001); there was no signifcant diference in any of the other chemokines. There was a signifcant positive correlation between the rates of increase of serum CCL2 (median [range]: 106.0% [-44.7% to 557.4%]) and tryptase (133.8% [-6.6% to 893.4%]; r=0.68, P<0.0001) and between the acute concentration of serum CCL2 and the acute concentration of serum tryptase (r=0.77, P<0.0001). The number of circulating basophils, but not other blood cells, signifcantly decreased during anaphylaxis (median 5.0 vs. 19.1 cells/[micro]l in convalescent samples; P<0.0001); a decrease in whole-blood gene expression of basophil markers (P=0.0018) confirmed these changes. Anaphylactic serum enhances the in vitro migration of basophils via CCL2-dependent chemotactic activity; in contrast, no CCL2-dependent chemotactic activity was observed for convalescent samples. Conclusions: Our findings imply an important and specifc role for CCL2-mediated chemotactic activity in the pathophysiology of human anaphylaxis. Keywords: anaphylaxis, chemokines, tryptases, basophils, chemotaxis, CCL2, cell migration Published in DiRROS: 18.01.2021; Views: 1369; Downloads: 633 Full text (2,04 MB) |
258. Platformne storitveAna Robnik, Andrej Ciglič, Aleš Balanč, Dušan Gabrijelčič, Jan Porekar, Arso Savanović, Polona Škraba, Roman Kužnar, Ignac Zupan, 2015, published scientific conference contribution Published in DiRROS: 08.12.2020; Views: 1314; Downloads: 393 Full text (608,68 KB) |
259. Težke odločitve pri zdravljenju bolnikov z vensko trombembolijo in rakomAna Kovač Bograf, Monika Štalc, Gregor Tratar, Alenka Mavri, 2016, review article Abstract: Venska trombembolija (VTE) je pogost zaplet pri bolnikih z rakom. Zdravljenje VTE pri teh bolnikih predstavlja velik izziv, saj je pri bolnikih z rakom dodatno povečano tako tveganje za trombembolične zaplete kot tudi tveganje za krvavitve. Predstavili bomo nekaj kliničnih situacij, s katerimi se v klinični praksi pogosto srečamo in predstavljajo dileme pri antikoagulacijskem zdravljenju bolnikov z VTE ter rakom, in sicer ponovitve VTE kljub zdravljenju, pojav trombocitopenije, tumorje osrednjega živčevja, uporabo filtrov v spodnji votli veni, uporabo novih peroralnih antikoagulacijskih zdravil in pojav naključno odkrite VTE. Keywords: venska trombembolija, rak (medicina), zdravljenje Published in DiRROS: 03.12.2020; Views: 1361; Downloads: 573 Link to full text This document has many files! More... |
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