21. Genotyping of BRCA1, BRCA2, p53, CDKN2A, MLH1 and MSH2 genes in a male patient with secondary breast cancerAna Lina Vodušek, Srdjan Novaković, Vida Stegel, Berta Jereb, 2011, original scientific article Published in DiRROS: 18.03.2024; Views: 85; Downloads: 32
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22. Study of radiation induced changes of phosphorus metabolism in mice by ▫$^{31}P$▫ NMR spectroscopyIgor Serša, Simona Kranjc Brezar, Gregor Serša, Alenka Nemec Svete, Bojan Ložar, Ana Sepe, Jernej Vidmar, Marjeta Šentjurc, 2010, original scientific article Published in DiRROS: 15.03.2024; Views: 94; Downloads: 32
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23. Trilinear embedding for divergence-form operators with complex coefficientsAndrea Carbonaro, Oliver Dragičević, Vjekoslav Kovač, Kristina Ana Škreb, 2023, original scientific article Abstract: We prove a dimension-free $L^p(\Omega)\times L^q(\Omega)\times L^r(\Omega)\rightarrow L^1(\Omega\times (0,\infty))$ embedding for triples of elliptic operators in divergence form with complex coefficients and subject to mixed boundary conditions on $\Omega$, and for triples of exponents $p,q,r \in (1,\infty)$ mutually related by the identity $1/p+1/q+1/r=1$. Here $\Omega$ is allowed to be an arbitrary open subset of $\mathbb{R}^d$. Our assumptions involving the exponents and coefficient matrices are expressed in terms of a condition known as $p$-ellipticity. The proof utilizes the method of Bellman functions and heat flows. As a corollary, we give applications to (i) paraproducts and (ii) square functions associated with the corresponding operator semigroups, moreover, we prove (iii) inequalities of Kato-Ponce type for elliptic operators with complex coefficients. All the above results are the first of their kind for elliptic divergence-form operators with complex coefficients on arbitrary open sets. Furthermore, the approach to (ii),(iii) through trilinear embeddings seems to be new.
Keywords: elliptic differential operator, p-ellipticity, operator semigroup, multilinear estimate
Published in DiRROS: 15.03.2024; Views: 88; Downloads: 51
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24. Reviewing the modeling aspects and practices of shallow geothermal energy systemsPaul Christodoulides, Ana Vieira, Stanislav Lenart, João Maranha, Gregor Vidmar, Rumen Popov, Aleksandar Georgiev, Lazaros Aresti, Georgios Florides, 2020, review article Abstract: Shallow geothermal energy systems (SGES) may take different forms and have recently taken considerable attention due to energy geo-structures (EGS) resulting from the integration of heat exchange elements in geotechnical structures. Still, there is a lack of systematic design guidelines of SGES. Hence, in order to contribute towards that direction, the current study aims at reviewing the available SGES modeling options along with their various aspects and practices. This is done by first presenting the main analytical and numerical models and methods related to the thermal behavior of SGES. Then, the most important supplementary factors affecting such modeling are discussed. These include: (i) the boundary conditions, in the form of temperature variation or heat flow, that majorly affect the predicted thermal behavior of SGES; (ii) the spatial dimensions that may be crucial when relaxing the infinite length assumption for short heat exchangers such as energy piles (EP); (iii) the determination of SGES parameters that may need employing specific techniques to overcome practical difficulties; (iv) a short-term vs. long-term analysis depending on the thermal storage characteristics of GHE of different sizes; (v) the influence of groundwater that can have a moderating effect on fluid temperatures in both heating and cooling modes. Subsequently, thermo-mechanical interactions modeling issues are addressed that may be crucial in EGS that exhibit a dual functioning of heat exchangers and structural elements. Finally, a quite lengthy overview of the main software tools related to thermal and thermo-hydro-mechanical analysis of SGES that may be useful for practical applications is given. A unified software package incorporating all related features of all SGES may be a future aim.
Keywords: shalow geothermal energy systems, energy geo-structures, thermal analysis, thermo-hydro-mechanical, modelling, software tools
Published in DiRROS: 05.03.2024; Views: 126; Downloads: 56
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25. Metal–support interaction between titanium oxynitride and Pt nanoparticles enables efficient low-Pt-loaded high-performance electrodes at relevant oxygen reduction reaction current densitiesArmin Hrnjić, Ana Rebeka Kamšek, Lazar Bijelić, Anja Logar, Nik Maselj, Milutin Smiljanić, Jan Trputec, Natan Vovk, Luka Pavko, Francisco Ruiz-Zepeda, Marjan Bele, Primož Jovanovič, Nejc Hodnik, 2024, original scientific article Published in DiRROS: 04.03.2024; Views: 127; Downloads: 55
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27. Incidenca raka v prvem letu epidemije covida-19Vesna Zadnik, Tina Žagar, Nika Bric, Mojca Birk, Amela Duratović Konjević, Ana Mihor, Katarina Lokar, Sonja Tomšič, 2023, professional article Abstract: Uvod: Število novih diagnoz raka (incidenca) se v Sloveniji v zadnjem desetletju povečuje za povprečno 1,6 % na leto. V letu 2020, prvem letu omejitvenih ukrepov zaradi epidemije covida19, smo s platformo OnKOvid predvideli 3–8-odstotni padec novih diagnoz raka. Namen je predstaviti uradno incidenco raka za Slovenijo za leto 2020 in ugotoviti, kolikšen je bil dejansko manko novih diagnoz raka. Metode: V Registru raka Republike Slovenije smo v skladu z mednarodnimi pravili registrirali vse nove primere raka pri prebivalcih s stalnim prebivališčem v Sloveniji. Primerjali smo jih z registrirano incidenco za 2019, modelno incidenco za 2020, preliminarnimi rezultati OnKovida in dostopnimi rezultati incidence iz registrov raka iz drugih držav. Rezultati: V letu 2020 je za rakom zbolelo 15.096 oseb v Sloveniji (7.034 žensk, 8.002 moška). Glede na modelno oceno incidence za leto 2020 gre za manko 1.854 oseb (10,9 %; 11,6 % žensk, 10,4 % moških). Pri tem je za 10,5 % manj ugotovljenih rakov v omejenem stadiju, najbolj izrazito v starosti 50–69 let (za 13,2 %). Upad je primerljiv s poročili iz Anglije, ZDA in Kanade ter deloma večji kot na Škotskem in Švedskem. Najbolj izrazit upad novih diagnoz raka ugotavljamo pri nemelanomskem kožnem raku (23 %, najbolj po 50. letu), raku prostate (15,9 %, najbolj v omejenem stadiju), pljučnem raku (8,9 %, 60–64 let, v razširjenem stadiju), raku dojk (8,3 %, 45–64 let), ne-Hodgkinovem limfomu (9 %) in levkemijah (11,6 %). Pri kožnem melanomu, raku debelega črevesa in danke ni bilo primanjkljaja. Zaključek: Upad incidence raka v letu 2020 gre verjetno na račun omejitvenih ukrepov, reorganizacije zdravstva in z zdravjem povezanega vedenja med epidemijo covida-19, beležijo jo v več državah. Med epidemijami je potrebno nemoteno izvajanje onkologije.
Keywords: rak, incidenca, register raka, epidemija, covid-19
Published in DiRROS: 26.02.2024; Views: 158; Downloads: 36
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29. The role of p38 MAP kinase in cancer cell apoptosisMetka Lenassi, Ana Plemenitaš, 2006, review article Abstract: Background. Cellular behaviour in response to many extracellular stimuli is mediated through MAP kinase signalling pathways. p38 MAP kinase that is represented in mammals by four isoforms (p38alfa, p38beta, p38gama and p38delta) is one of the four main subgroups of MAP kinases. Recent studies show that p38 activation is necessary for cancer cell death initiated by variety of anti-cancer agents. This finding connected cancer therapies previously considered to be mechanistically unrelated and raised the possibility of developing anti-cancer agents that lack the side effects causedby events upstream of p38 MAPK Many of the details of p38 induced apoptosis still need to be elucidated. Since most of the past studies rely only on the cell culture models, all the results have to be verified using in vivo models. Also very little is known about the role of p38 mediated apoptosis on non-neoplastic cells in response to anti-cancer agents. Conclusion. Although p38 activation of cancer cell apoptosis is a very complexprocess, recent studies indicate a good starting point for new strategies that would increase the efficiency and decrease the toxicity of proven therapies.
Published in DiRROS: 15.02.2024; Views: 136; Downloads: 27
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30. Schedule-dependency of doxorubicin and vinblastine in EAT tumours in miceMarija Auersperg, Ana Pogačnik, Veronika Kloboves-Prevodnik, Gregor Serša, Maja Čemažar, 2006, original scientific article Abstract: Background. Antitumour schedule-dependency of the doxorubicin and vinblastine combination was explored. Materials and methods. Intraperitoneal Ehrlich ascites tumours (EAT) syngeneic to CBA mice were treated with vinblastine ar doxorubicin alone, or in combined treatment schedules. Results. Combinations of doxorubicin and vinblasfine administered at 48-h, but not at 24-h interval,regardless of the sequence of drugs, significantly reduced the numberof tumour cells in the ascites in corrtparison with all other treatments. In the combined treatment schedules, the predominant morphologicalchanges as well as DNA distribution pattern were dependent on thefirst drug applied. Regardless of the sequence of the drugs, median survival times of animals did not significantly differ between the treatment groups. Conclusions. The effect of combination of vinblastine and doxorubicin is schedule-dependent. The time interval, but not the sequence of drugs seems to be crucial for the observed effect. The data from preclinical studies are important for planning combined treatment schedules in clinical setting.
Published in DiRROS: 15.02.2024; Views: 104; Downloads: 25
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