591. Intestinal involvement in graft versus host disease in children : an overview by the ESPGHAN Gastroenterology CommitteeMarina Vincent, Amit Assa, Osvaldo Borrelli, Matjaž Homan, Javier Martin-de-Carpi, Zrinjka Mišak, Maria Giovanna Puoti, Isabelle Scheers, Sara Sila, Caterina Strisciuglio, Christos Tzivinikos, Jernej Dolinšek, Emmanuel Mas, 2025, review article Abstract: Graft versus host disease (GVHD) is a complication that frequently occurs afterhaematopoietic stem cell transplantation and concerns many children in paediatrichaematology‐oncology and bone marrow transplantation departments. It can affectvarious organs, with the skin, gastrointestinal tract and liver being the most com-monly involved. To confirm intestinal GVHD and to rule out differential diagnosesendoscopy is frequently needed. Currently, there are no specific consensus rec-ommendations concerning the best method for endoscopic exploration and medicalmanagement of this disease in children, with limited studies available, including alow number of patients. Sigmoidoscopy could be initially proposed under sedation. Ifsigmoidoscopy is normal or if a general anaesthesia is required, colonoscopy andupper endoscopy should be planned, avoiding duodenal biopsy because of the riskof duodenal haematoma. Regarding therapeutic options, corticosteroids are thefirst‐line treatment for GVHD. Ruxolitinib, a Janus kinase inhibitor, is indicated forchildren aged 12 years and older with acute or chronic GVHD who have aninadequate response to corticosteroids or other systemic therapies. Nutritionalsupport has a key role in the management of intestinal GVHD and should beconsidered to guarantee the best possible evolution of intestinal GVHD.
Keywords: GVHD, children, complication, endoscopy, haematopoietic stem cell transplantation, intestine
Published in DiRROS: 14.11.2025; Views: 143; Downloads: 73
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597. What is a circular economy champion? Defining a home-grown concept in an emerging fieldDolores Modic, Sahana Swaroop Chetan, Shajara Ul-Durar, Noman Arshed, Marco De Sisto, Nadja Damij, 2025, original scientific article Abstract: Circular economy, which aims to keep resources in production cycles and minimize waste, has emerged as a viable alternative to the traditional linear model. However, it is often criticized for being under-theorized and lacking indigenous, home-grown concepts, particularly regarding fundamental elements such as actors and actor types. This paper focuses on a specific actor: the circular economy champion. Circular economy champions can drive the transition toward a more circular economy, yet the concept remains under-conceptualized despite a growing body of literature. The aims of this study are twofold: first, to highlight the importance of home-grown concepts in emerging fields; and second, to address the ambiguity surrounding the terminology of “circular economy champion” by providing a novel conceptualization. The paper develops this concept using a family resemblance approach, employing differentiation criteria through a piecemeal method and underpinned by a theoretical review of the literature. By extending both the scope of actor types and, based on their traits, the range of their attributes, activities, and contributions to the circular economy, the concept of the circular economy champion is further delineated from related constructs and firmly defined. This contributes to circular economy discourse by proposing a novel definition of a key actor within the circular economy system, thus strengthening its theoretical foundations. Moreover, the proposed definition reduces ambiguity in understanding actors’ roles within the circular economy, further clarifying its microfoundations.
Keywords: circular economy, actor, circular economy champion, concept development
Published in DiRROS: 13.11.2025; Views: 154; Downloads: 76
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598. Quantum computing and the stable set problemAljaž Krpan, Janez Povh, Dunja Pucher, 2025, original scientific article Abstract: Given an undirected graph, the stable set problem asks to determine the cardinality of the largest subset of pairwise non-adjacent vertices. This value is called the stability number of the graph, and its computation is an NP-hard problem. In this paper, we solve the stable set problem using the D-Wave quantum annealer. By formulating the problem as a quadratic unconstrained binary optimization problem with the penalty method, we show its optimal value equals the graph's stability number for specific penalty values. However, D-Wave's quantum annealer is a heuristic, so the solutions may be far from the optimum and may not represent stable sets. To address these, we introduce a post-processing procedure that identifies samples that could lead to improved solutions. Additionally, we propose a partitioning method to handle larger instances that cannot be embedded on D-Wave's quantum processing unit. Finally, we investigate how different penalty parameter values affect the solutions' quality. Extensive computational results show that the post-processing procedure significantly improves the solution quality, while the partitioning method successfully extends our approach to medium-size instances.
Keywords: stable set problem, quantum annealing, graph partitioning, D-Wave
Published in DiRROS: 13.11.2025; Views: 187; Downloads: 95
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600. Mycoplasma arginini cellulitis, tenosynovitis, and arthritis in kidney transplant recipient, Slovenia, 2024Tjaša Vivoda, Tereza Rojko, Barbara Kokošar Ulčar, Katja Strašek Smrdel, Andraž Celar Šturm, Darja Keše, Tina Triglav, Željka Večerić-Haler, 2025, other scientific articles Abstract: Mycoplasma arginini is a bacterium primarily found in animals and is seldom reported in human infections. We identified M. arginini infection in a severely immunocompromised kidney transplant recipient in Slovenia. Clinicians should be aware of M. arginini's potential as a pathogen in immunocompromised persons with animal contact.
Keywords: Mycoplasma arginini, Slovenia, arthritis, bacteria, cellulitis, immunocompromised, kidney transplant recipient, zoonoses
Published in DiRROS: 13.11.2025; Views: 156; Downloads: 80
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