931. Dynamic expression of 11 miRNAs in 83 consecutive primary and corresponding recurrent glioblastoma : correlation to treatment, time to recurrence, overall survival and MGMT methylation statusBoštjan Matos, Emanuela Boštjančič, Alenka Matjašič, Mara Popović, Damjan Glavač, 2018, original scientific article Abstract: Background. Glioblastoma (GBM) is the most common and the most malignant glioma subtype. Among numerous genetic alterations, miRNAs contribute to pathogenesis of GBM and it is suggested that also to GBM recurrence and resistance to therapy. Based on publications, we have selected 11 miRNAs and analyzed their expression in GBM. We hypothesized that selected miRNAs are differentially expressed and involved in primary as well as in recurrent GBM, that show significant expressional differences when different treatment options are in question, and that are related to certain patients and tumor characteristics. Patients and methods. Paraffin embedded tissues, obtained from primary and corresponding recurrent tumor from 83 patients with primary GBM were used. Eleven miRNAs ( miR-7, miR-9, miR-15b, miR-21, miR-26b, miR-124a, miR-199a, let-7a, let-7b, let-7d, and let-7f ) were selected for qPCR expression analysis. For patients who received temozolamide (TMZ) as chemotherapeutic drug, O6-methylguanine-DNA methyltransferase (MGMT) methylation status was defined using the methyl-specific PCR. Results. There was a significant change in expression of miR-7, miR-9, miR-21, miR-26b, mirR-124a, miR-199a and let- 7f in recurrent tumor compared to the primary. In recurrent tumor, miR-15b, let-7d and let-7f significantly changed comparing both treatment options. We also observed difference in progression free survival between patients that received radiotherapy and patients that received radiotherapy and chemotherapy, and longer survival for patients who received chemotherapy after second surgery compared to not treated patients. miR-26b showed correlation to progression free survival and let-7f to overall survival. We did not find any expression difference between the tumors with and without methylated MGMT. Conclusions. Our data suggest that analyzed miRNAs may not only contribute to pathogenesis of primary GBM, but also to tumor progression and its recurrence. Moreover, expression of certain miRNAs appears to be therapy- dependent and as such they might serve as additional biomarker for recurrence prediction and potentially predict a therapy-resistance. Keywords: glioblastoma, radiotherapy, chemotherapy Published in DiRROS: 02.07.2024; Views: 189; Downloads: 110
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932. Three-dimensional ultrasound evaluation of tongue posture and its impact on articulation disorders in preschool children with anterior open biteSanda Lah Kravanja, Irena Hočevar-Boltežar, Maja Marolt-Mušič, Ana Jarc, Ivan Verdenik, Maja Ovsenik, 2018, original scientific article Abstract: Background. Tongue posture plays an important role in the etiology of anterior open bite (AOB) and articulation disorders, and is crucial for AOB treatment planning and posttreatment stability. Clinical assessment of tongue posture in children is unreliable due to anatomical limitations. The aim of the study was to present functional diagnostics using three-dimensional ultrasound (3DUS) assessment of resting tongue posture in comparison to clinical assessment, and the associations between the improper tongue posture, otorhinolaryngological characteristics, and articulation disorders in preschool children with AOB. Patients and methods. A cross-sectional study included 446 children, aged 3-7 years, 236 boys and 210 girls, ex- amined by an orthodontist to detect the prevalence of AOB. The AOB was present in 32 children. The control group consisted of 43 children randomly selected from the participants with normocclusion. An orthodontist, an ear, nose and throat (ENT) specialist and a speech therapist assessed orofacial and ENT conditions, oral habits, and articulation disorders in the AOB group and control group. Tongue posture was also assessed by an experienced radiologist, us- ing 3DUS. The 3DUS assessment of tongue posture was compared to the clinical assessment of orthodontist and ENT specialist. Results. The prevalence of AOB was 7.2%. The AOB group and the control group significantly differed regarding improper tongue posture (p < 0.001), and articulation disorders (p < 0.001). In children without articulation disorders from both groups, the improper tongue posture occured less frequently than in children with articulation disorders (p < 0.001). After age adjustment, a statistical regression model showed that the children with the improper tongue posture had higher odds ratios for the presence of AOB (OR 14.63; p < 0.001) than the others. When articulation disor- ders were included in the model, these odds ratios for the AOB became insignificant (p = 0.177). There was a strong association between the improper tongue posture and articulation disorders (p = 0.002). The 3DUS detected the high- est number of children with improper resting tongue posture, though there was no significant difference between the 3DUS and clinical assessments done by orthodontist and ENT specialist. Conclusions. The 3DUS has proved to be an objective, non-invasive, radiation free method for the assessment of tongue posture and could become an important tool in functional diagnostics and early rehabilitation in preschool children with speech irregularities and irregular tongue posture and malocclusion in order to enable optimal condi- tions for articulation development. Keywords: anterior open bite, tongue posture, three-dimensional ultrasound Published in DiRROS: 02.07.2024; Views: 196; Downloads: 109
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933. Sclerosing melanocytic lesions (sclerosing melanomas with nevoid features and sclerosing nevi with pseudomelanomatous features) : an analysis of 90 lesionsBiljana Grčar-Kuzmanov, Emanuela Boštjančič, Juan Antonio Contreras, Jože Pižem, 2018, original scientific article Abstract: Background. Sclerosing melanocytic lesions, which are characterized by either focal or diffuse sclerosis in the dermal component and atypical proliferation of predominantly nevoid melanocytes, remain poorly defined. Our aim was to analyze systematically their morphologic spectrum, especially the distinction between sclerosing melanocytic nevus and sclerosing melanoma, which has not been well documented. Patients and methods. We collected 90 sclerosing melanocytic lesions, occurring in 82 patients (49 male, 33 female; age range from 21 to 89 years). A four probe fluorescent in situ hybridization (FISH) assay was performed in 41 lesions to substantiate the diagnosis of sclerosing melanomas. Results. A prominent full-thickness pagetoid spread of melanocytes was identified in 44 (48%) lesions, and a melanoma in situ adjacent to the sclerosis in 55 (61%) lesions. In the intrasclerotic component, maturation was absent in 40 (44%) and mitotic figures were identified in 18 (20%) lesions. Of the 90 lesions, 26 (29%) were diagnosed morphologically as nevi and 64 (71%) as melanomas (Breslow thickness from 0.4 to 1.8 mm), including 45 (50%) melanomas with an adjacent nevus. A four-probe FISH assay was positive in the sclerotic component in 14 of 25 lesions diagnosed morphologically as melanomas and none of 16 nevi. A sentinel lymph node biopsy was performed for 17 lesions and was negative in all cases. Conclusions. Sclerosing melanocytic lesions form a morphologic spectrum and include both nevi and melanomas. The pathogenesis of sclerosis remains obscure but seems to be induced by melanocytes or an unusual host response in at least a subset of lesions. Keywords: sclerosing melanoma, sclerosing nevus, fibrosis Published in DiRROS: 02.07.2024; Views: 200; Downloads: 185
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934. Poročilo o spremljanju stanja gozdov za leto 2023 : vsebinsko poročilo o spremljanju stanja gozdov v skladu s Pravilnikom o varstvu gozdov (2009)Andrej Grah, Janez Kermavnar, Nike Krajnc, Lado Kutnar, Tom Levanič, Nikica Ogris, Anže Martin Pintar, Matej Rupel, Mitja Skudnik, Primož Simončič, Saša Šercer, Urša Vilhar, Daniel Žlindra, 2024, final research report Keywords: varstvo gozdov, monitoring, stanje gozdov, zdravstveno stanje krošenj, popis povzročiteljev poškodb, meteorološke meritve, osutost dreves, poročila, Slovenija Published in DiRROS: 02.07.2024; Views: 188; Downloads: 214
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935. Vegetacijske in talne razmere v izbranih gozdovih Konjiške gore v GGE Slovenske KonjiceValerija Babij, Aleksander Marinšek, Lado Kutnar, Peter Horvat, Matej Tajnikar, Urban Orož, Marko Lekše, Bojan Bračič, Niko Laznik, Andrej Breznikar, Erika Kozamernik, 2024, treatise, preliminary study, study Keywords: vegetacija, tla, rastišča, ekologija gozdov, Javna gozdarska služba, Slovenija Published in DiRROS: 02.07.2024; Views: 224; Downloads: 132
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936. Vegetacijske in talne razmere v izbranih gozdovih GGE Brkini IValerija Babij, Aleksander Marinšek, Lado Kutnar, Peter Horvat, Matej Reščič, Erika Kozamernik, 2024, treatise, preliminary study, study Keywords: vegetacija, tla, rastišča, ekologija gozdov, Javna gozdarska služba, Slovenija Published in DiRROS: 02.07.2024; Views: 208; Downloads: 99
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937. Vegetacijske in talne razmere v izbranih gozdovih Bele krajineValerija Babij, Aleksander Marinšek, Lado Kutnar, Peter Horvat, Andrej Držaj, Andrej Kotnik, Roman Šimic, Erika Kozamernik, 2024, treatise, preliminary study, study Keywords: vegetacija, tla, rastišča, ekologija gozdov, Javna gozdarska služba, Slovenija Published in DiRROS: 02.07.2024; Views: 229; Downloads: 110
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938. Indoor navigation with a SmartphoneDrago Torkar, 2024, independent scientific component part or a chapter in a monograph Abstract: This chapter presents a cost-effective system for indoor localization and navigation that does not require the use of satellite positioning or data communication networks. The system, implemented as a smartphone app, relies on QR codes that are pre-generated and attached to the walls inside the building. By utilizing the information from these codes and the smartphone’s inertial motion unit (IMU) sensors processed by the Pedestrian Dead-Reckoning (PDR) algorithm, the user’s current position can be determined. The Dijkstra navigation algorithm is then used to guide the user to the desired destination. The smartphone app can also be used as a healthcare logistics service in mass-casualty incidents for collecting and reporting georeferenced triage decisions to the cloud. Keywords: internet thinks, indoor navigation, systems, QR codes Published in DiRROS: 02.07.2024; Views: 167; Downloads: 94
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939. Explainable anomaly detection of 12-Lead ECG signals using denoising autoencoderRok Hribar, Drago Torkar, 2024, independent scientific component part or a chapter in a monograph Abstract: The basic idea was to create a proof of concept demonstrating that the indoor navigation and localisation is possible using only passive tags. For this purpose, a smartphone navigation app was developed to be used in inner parts of the buildings and which can operate with no satellite positioning service available and no communication network present. The satellite navigation systems (GPS, GLONASS, Galileo, BeiDou, QZSS, IRNSS) inside buildings, at least on lower floors and cellars, in central parts, and away from windows, usually do not work, or their accuracy is very reduced due to a small number of visible satellites. The communication networks (WiFi, LTE, 5G…) might not be available in some circumstances such as catastrophic incidents, power reductions, or similar, which disables the localisation systems based on them. The purpose of the smartphone app was twofold. First, to develop a reliable, simple-to-use, and cheap indoor navigation system that could be used in large buildings like hospitals, shopping malls, trade centres, fairs, etc. where no other positioning service is available. Second, to develop an indoor position reporting system that can be used in accidents and mass-casualty incidents for reporting triage decisions to the server. Both functionalities are based on the QR codes [1] holding all the information needed. Keywords: internet thinks, indoor navigation, systems, QR codes Published in DiRROS: 02.07.2024; Views: 158; Downloads: 105
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940. The powerful class of groupsPrimož Moravec, 2024, original scientific article Abstract: Pro-$p$ groups of finite powerful class are studied. We prove that these are $p$-adic analytic, and further describe their structure when their powerful class is small. It is also shown that there are only finitely many finite $p$-groups of fixed coclass and powerful class. Keywords: finite p-groups, powerful class, pro-p groups Published in DiRROS: 02.07.2024; Views: 134; Downloads: 76
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