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Abstract: Background. The irradiation of the carcinomas of the prostate with the doses above the tolerable ones of standard radiotherapy improves the local control of the disease. The aim of this study is to determine the acute toxicity and tolerability of the high-dose prostate irradiation combining external beam radiotherapy (EBRT) and interstitial low dose rate (LDR) brachyradiotherapy (BRT) Ir-192 of the prostate. Material and methods. We examined medical records of 8 patients with localized carcinoma of the prostate (T2-T3 No-x Mo)treated from August 1999 until February 2000. The initial PSA was 2.7-37.5 ng/ml (median 13.7) and Gleason score 4-9 (median 7). Radiotherapy consisted of 48.6-50.4 Gy of EBRT to the prostate and seminal vesicles (4 patients) or the whole pelvis (4 patients) and 20.0-28.0 Gy of interstital LDR Ir-192 BRT given as a single fraction, fluoroscopic guided transperineal Implantation of the prostate. The cumulative doses of percutaneous and interstitial irraditations to the prostate were 68.6 - 79.1 Gy. Results. Acute toxic effects of irradiation though observed in all patients were of only mild intensity. According to the RTOG criteria, 20/30 toxicities were assessed as grade 1, 9/30 as grade 2, and 1/30 as grade 3. In none of the patients, toxic effects required any specific modification of the treatment regimen. Conclusions. The very first experiences indicate moderate toxicity and optimaltolerance of the treatment by patients. An improvement of implantation techniques may be expected with regular CT controls of the implants and extra attentive care of the implants in the urethra region.
Published in DiRROS: 25.01.2024; Views: 213; Downloads: 80
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Abstract: Background. In this work, we describe the computer systems Viprecox and ActiveContours that are used in the process of realistic estimation of some biomechanical parameters of the hip joint, including the maximal value of the stress in the hip joint p max. The computer system Active Contours uses standard anteroposterior radiographs of the whole pelvis and both hips for itscalculations and Viprecox in its kernel uses a relatively simple three-dimensional mathematical model of stress distribution in the hip-joint articular surface which has been extensively elsewhere (e.g. Iglič 1996). Material and methods. Both state-of-the-art computer systems were tested by analysing the calculated values of p max for 81 patients (37 males and 44 females). Conclusions. In this way we prove that the described computer systems can be used for the determination of the contact stress distribution from standard AP radiographs.
Published in DiRROS: 25.01.2024; Views: 220; Downloads: 44
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Abstract: Background. The purpose of this preliminary study was to evaluate a novel luminescence-based fiber-optic sensor (OxyLite system) for the measurement of partial pressure of oxygen (pO2) in tumors and for the detection of changes inpO2 as a function of time. The new method was used simultaneously with the laser Doppler flowmetry method for the measurement of relative tissue perfusion. Materials and methods. Blood perfusion and pO2 were measured continuously via fiber-optic sensors inserted into SA-1 tumors in anesthetizedAžJ mice. The changes in blood flow and oxygenation of tumors wereinduced by transient changes of the parameters of anesthesia and by injection of a vasoactive drug hydralazine. Results. Both optical methods usedin the study successfully detected the induced changes in blood flow and pO2. The measurements of pO2 were well correlated with measurements of microcirculatory blood perfusion. In the majority of pO2 measurements, we observed an unexpected behavior of the signal during the stabilization processimmediately after the insertion of the probe into tumor. This behaviourof the pO2 signal was most probably caused by local tissue damage induced by the insertion of the probe. Conclusion. The novel luminescence-based optical oximetry can reliably detect local pO2 changes in tumors as a function of time but some aspects of prolonged pO2 measurement by this method require further investigation.
Keywords: sarcoma experimental, blood supply, laser-doppler flowmetry, oxygen, luminiscence
Published in DiRROS: 25.01.2024; Views: 275; Downloads: 91
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Abstract: Background. The aim of the study was to emphasize the importance of surgical management of squamous cell carcinoma (SCC) in the head and neck to find the most important predictive factor for cervical lymph node metastasis and prognostic factor for survival. The use of multimodality therapy is being discussed as well. Patients and methods. From June 1st, 1992 to May 31st, 1998, 154 patients with oral cavity and oropharyngeal SCC were admitted to the Department of Otorhinolaryngology and Cervicofacial Surgery in the Teaching Hospital of Maribor. The criteria for inclusion into the study were met by 142 patients, but only 62/142 patients entered the multimodality protocol (surgery and postoperative radiotherapy). These 62/142 patients were treated surgically and 49 of them were postoperatively irradiated, while 13/62 declined postoperative radiotherapy. Surgical specimen was evaluated for positive or negative lymph nodes, tumor margins and the depth of invasion. Tumor cells were stained for Ki67 proliferative factor. Results. The depth of invasion was the most important predictive factor for the neck metastases in multivariate model including also the grade, pT and T. pN was found to be important in determining the overall survival using Cox regression model (p>0,05). A statistically important discrepancy between N and pN classification was found. In 23 cases N was overrated and in 3 cases underrated. The overall 5-year disease specific survival was 55%. Ki67 correlated with the grade of tumor differentiation. No statistically significant correlation was found with lymph node metastases. Conclusions. The depth of invasion is the most important determining the occurrence of the neck metastases whereas the N status determines the survival.
Published in DiRROS: 25.01.2024; Views: 200; Downloads: 50
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Abstract: Na sadikah rdečega in črnega bora smo testirali patogenost osmih izbranih izolatov gliv (Corinectria fuckeliana, Diaporthe eres, Diplodia pinea, Fusarium sp. 1 in 2, Fusicolla sp., Nectria dematiosa in Tympanis sp.), ki smo jih izolirali iz obolelih borovih dreves v Sloveniji v letih 2020 in 2021. Inokulirali smo skupno 115 sadik borov (vključno s kontrolo), periodično smo preverjali njihovo zdravstveno stanje in ob prvih znakih sušenja opravili reizolacije iz robov nastalih nekroz. Reizolacije so bile uspešne le v primeru inokulacije z vrstami gliv Diplodia pinea, Diaporthe eres in Fusarium sp. 2. Povprečna dolžina nekroz sadik rdečega bora, inokuliranih z D. pinea, Di. eres in Tympanis sp., se je statistično značilno razlikovala od kontrolnih sadik (p < 0,05). Pri sadikah črnega bora pa so se za statistično značilne izkazale povprečne dolžine nekroz pri kontroli in inokulacijah z glivama D. pinea in Tympanis sp. (p < 0,05).
Keywords: test patogenosti, reizolacije, Pinus sylvestris, rdeči bor, Pinus nigra, črni bor
Published in DiRROS: 25.01.2024; Views: 632; Downloads: 253
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