1641. Netnografija kot metoda proučevanja vzdušja na območjih kulturne dediščine : primer medine v TlemcenuIkram Khemies, Mohammed Nabil Ouissi, Walid Hamma, 2025, original scientific article Abstract: Konstrukt turizma je prelomna oblika kapitalistične produkcije prostora, ki ustvarja nove urbane oblike. V številnih arhitekturnih in morfoloških študijah so analizirali različne modele, manjkajo pa primerjave njihovih značilnosti. Avtorji so v članku primerjali štiri vrste turizma, povezane z razvojem kapitalizma (vključno s predfordizmom, fordizmom in postfordizmom), in različne vrste turističnih mest. V povezavi z gospodarskimi, socialnimi in kulturnimi značilnostmi so analizirali njihovo arhitekturno ikoničnost, morfološke vzorce in prostorsko metriko. Izsledki kažejo, da predfordistični in fordistični konstrukti turizma, za katere je značilna visoka gostota zazidave, spodbujajo družbene odnose in povečujejo sposobnost ustvarjanja mesta, postfordistični konstrukti turizma z nizko gostoto zazidave pa povzročajo višje okoljske stroške (porast zasebnih zelenih in vodnih površin) in višje družbene stroške zaradi arhitekturne ikoničnosti. Avtorji so proučevali povezavo med arhitekturnimi in urbanističnimi spremenljivkami, ki bi jih bilo treba upoštevati pri načrtovanju turističnih destinacij v okviru kapitalistične produkcije turističnega prostora.
Keywords: vzdušje, urbana dediščina, netnografija, duh kraja, medina v Tlemcenu, Alžirija
Published in DiRROS: 23.07.2025; Views: 462; Downloads: 336
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1646. Premierna izvedba helikopterskega spravila lesa v SlovenijiMatevž Triplat, Jaša Saražin, Peter Smolnikar, Gašper Ogrin, Nike Krajnc, 2025, professional article Keywords: gozdarstvo, spravilo lesa, transport po zraku, helikoptersko spravilo
Published in DiRROS: 22.07.2025; Views: 515; Downloads: 176
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1649. Basophil activation test predicts cetuximab anaphylaxis severity in alpha-gal IgE-positive patientsPeter Kopač, Ana Koren, Urška Bidovec, Mitja Košnik, Luka Dejanović, Tanja Mesti, Primož Strojan, Peter Korošec, Janja Ocvirk, 2024, original scientific article Abstract: Upon first exposure to cetuximab, hypersensitivity reactions can occur. We aimed to assess the utility of the basophil activation test (BAT) to alpha-gal and cetuximab for predicting severe reactions. We prospectively recruited 38 patients and evaluated sIgE to alpha-gal in all patients before the first application of cetuximab. In all alpha-gal-sensitized patients, we evaluated skin tests to meat extracts, gelatine, and cetuximab and performed BAT with alpha-gal and cetuximab. In 24% (9/38) of patients, sIgE to alpha-gal was >0.10 kUA/L, and 8/9 reacted to the cetuximab. Basophil activation tests with alpha-gal were positive in all sensitized patients and were higher in those with severe reactions (18.3% in grade 4 [n = 4] vs. 1.8% in grade 2 [n = 3] or no reaction [n = 1] at 3.3 ng/mL of alpha-gal; p = 0.03). All patients with severe grade 4 reactions had a positive CD63 BAT response to cetuximab compared to patients with moderate or no reaction, who all had negative BAT (57.7% vs. 0.9% at 500 µg/mL, 63.2% vs. 4.1% at 100 µg/mL, 58.2% vs. 2.7% at 10 µg/mL, and 32.1% vs. 3.3% at 1 µg/mL of cetuximab, respectively; p ≤ 0.001). In summary, before initiating cetuximab treatment, sIgE to alpha-gal should be assessed in all patients. To predict the severity of the reaction and to assess the risk of cetuximab-induced anaphylaxis, we should perform BATs with alpha-gal or more discriminative BATs with cetuximab.
Keywords: alpha-gal, baseline serum tryptase, basophil activation test, cetuximab, drug allergy
Published in DiRROS: 22.07.2025; Views: 621; Downloads: 279
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