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95. Rehabilitacija ginekoloških onkoloških bolnic : zbornik znanstvenih prispevkov2025, proceedings of peer-reviewed scientific conference contributions (domestic conferences) Keywords: ginekologija, onkologija, ginekološka onkologija, diagnostika, zdravljenje, etiologija, epidemiologija, klinična patologija, medicinska rehabilitacija, zborniki
Published in DiRROS: 10.12.2025; Views: 69; Downloads: 23
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96. Residual metabolic burden in young psoriasis patients successfully treated with biologicsEva Klara Merzel Šabović, Tadeja Kraner Šumenjak, Miodrag Janić, 2024, original scientific article Abstract: Metabolic disorders are common in patients with psoriasis and contribute significantly to an increased cardiovascular risk. While biologic therapy is very successful in clearing skin lesions, its impact on metabolic parameters is uncertain. Our aim was to investigate the residual metabolic burden in psoriasis patients successfully treated with biologic therapy. We conducted a cross-sectional study of 80 young patients (54 men, 26 women, aged 30–45 years) successfully treated with either adalimumab, secukinumab or guselkumab and topical therapy or methotrexate, and 20 healthy controls. Anthropometric parameters, lipid levels and metabolic indices (HOMA-IR, TyG index and FIB-4 index) were measured. Patients did not receive any other treatments to exclude confounding effects. After analysis, we found that patients treated with three different biologics had similar metabolic status, only the FIB-4 index was higher in the adalimumab group than in the secukinumab and guselkumab treatment groups. There were no significant differences between the patients treated with biologics and the control group. The comparison with patients treated topically or with methotrexate showed that only triglyceride levels, HOMA-IR, TyG index, and FIB-4 index were elevated in patients treated with adalimumab compared to patients treated with topical therapy. Finally, metabolic status was also similar in patients treated with methotrexate or topical therapy. In conclusion, this study suggests that psoriasis patients successfully treated with biologics have similar metabolic parameters to the control group and patients treated with topical therapy or methotrexate. This indicates that there is no significant residual metabolic burden in young patients successfully treated with biologics. These results are clinically relevant and should be considered in the treatment of psoriasis patients.
Keywords: psoriasis, residual metabolic burden, insulin resistance, biologic therapy
Published in DiRROS: 09.12.2025; Views: 111; Downloads: 54
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97. Rethinking osteoporosis drugs : can we simultaneously address sarcopenia?Zoran Gavrilov, Jasna Lojk, 2025, review article Abstract: Osteoporosis and sarcopenia are two aspects of the geriatric syndrome that frequently occur together and affect one another in a condition referred to as osteosarcopenia. Preventive and treatment options for osteosarcopenia exist but are mainly focused on the treatment of osteoporosis, as there is still no FDA-approved treatment for sarcopenia. Drugs for osteoporosis include antiresorptive and anabolic drugs and hormonal replacement therapies and are prescribed based on age, BMD and other patient characteristics, which, however, do not include the possible co-existence of sarcopenia. As several studies and clinical trials have shown that the pharmacological treatment of osteoporosis can also affect muscle tissue, in either a positive or negative manner, sarcopenia should be another factor affecting the choice of treatment, especially when facing equal treatment options for osteoporosis. The aim of this review was to summarize our current knowledge on the effects of FDA-approved drugs for the treatment of osteoporosis on muscle quality, mass and function. A better understanding of the effects that certain drugs have on muscle tissue might in the future help us to simultaneously at least partially also address the wasting of muscle tissue and avoid further pharmacologically induced decline.
Keywords: osteoporosis, sarcopenia, osteosarcopenia, pharmacological treatment
Published in DiRROS: 09.12.2025; Views: 106; Downloads: 44
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99. Influenza vaccine uptake in juvenile idiopathic arthritis during the COVID-19 pandemic : a multi-centre cross-sectional study by PRES vaccination working partyDespoina Maritsi, Noa Alpert, Maša Bizjak, Amit Ziv, Barbora Balažiová, Nataša Toplak, 2025, other scientific articles Abstract: Background: Children with rheumatic diseases are at risk for contracting severe influenza and COVID-19 and are thus targeted for these vaccination. Objectives: To assess the influenza (flu) vaccination rate in children with Juvenile Idiopathic Arthritis (JIA), investigate families’ attitudes towards the influenza vaccine, and the effect of the COVID-19 pandemic on flu vaccine uptake. Methods: This multi-centre, cross-sectional study was conducted across 9 countries. JIA caregivers completed an anonymous questionnaire about their children’s influenza vaccination, including the 2019–2020 and 2020–2021 seasons, including knowledge, and perceptions regarding influenza vaccination. Results: Based on responses from 655 JIA caregivers, 152 children (23.2%) received influenza vaccinations in the 2020–2021 season, representing a significant rise from 18.6% in the previous season (p < 0.01). The likelihood of vaccination was higher among employed/self-employed caregivers compared to unemployed (28.2% and 29.9% vs. 13.9%), and those with tertiary education versus elementary (28% vs. 9.7%), both p < 0.01. Concerns of children’s vulnerability to SARS-CoV-2 and severe COVID-19 disease due to JIA were prevalent (51.3% and 85.3% respectively), with 51.3% supporting COVID-19 vaccination. Caregivers who previously vaccinated their children for influenza showed a greater inclination towards SARS-CoV-2 vaccination (73.4% and 79.5%, p < 0.01). Conclusions: Families of children with JIA reported an increasing flu vaccine uptake and a high intention for COVID- 19 vaccine administration. Previous vaccination behavior was shown as a significant predictor of future behaviour. Strengthening health education may address fears and lead to better vaccine coverage against both influenza and SARS-CoV-2 in children with JIA and other inflammatory rheumatic diseases.
Keywords: influenza vaccine, juvenile idiopathic arthritis, JIA, COVID-19, vaccination, children
Published in DiRROS: 09.12.2025; Views: 93; Downloads: 89
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100. Effect of universal antibiotic prophylaxis on prevalence of surgical site infection after cesarean sectionAnja Čopi Jerman, Janja Zver, Miha Lučovnik, Samo Jeverica, 2025, original scientific article Abstract: Background/Objectives: Cesarean section (CS) is among the most common surgical procedures worldwide and is associated with a markedly increased risk of postpartum infection, including surgical site infection (SSI). International guidelines recommend routine prophylaxis for all CSs, but in Slovenia, it has traditionally been reserved for high-risk procedures, with limited SSI surveillance data. The aim of this study was to determine the incidence of SSI within 30 days after CS and to evaluate the impact of universal prophylaxis implemented in a regional secondary care teaching hospital. Methods: We conducted a retrospective observational cohort study including all CS performed during 2023 (risk-based-only prophylaxis) and 2024 (universal prophylaxis) at Izola General Hospital, Slovenia. SSI was defined according to ECDC criteria and identified from inpatient and outpatient records up to 30 days postoperatively. Logistic regression was used to assess associations between prophylaxis, clinical variables, and SSI. Results: Among 1055 deliveries (208 CS; 99 in 2023, 109 in 2024), the rate of antimicrobial prophylaxis increased from 58.6% to 89.0% (p < 0.001). The overall 30-day SSI incidence was 7.2%, with no significant difference between the pre- and post-implementation periods (8.1% vs. 6.4%, p = 0.644). Most infections (86.7%) were diagnosed after discharge and were superficial incisional SSI (60%). In multivariable analysis, prophylaxis was independently protective (adjusted OR 0.11; 95% CI 0.02–0.58; p = 0.009), while prelabor rupture of membranes (PROM) and higher maternal weight significantly increased SSI risk. Conclusions: Antibiotic prophylaxis was independently associated with a reduced risk of SSI following SC; however, the absolute infection rate did not decline significantly and remained moderate after implementation. PROM and higher maternal weight were additional independent risk factors. These findings support universal prophylaxis with optimization for high-risk women and ongoing hospital and national surveillance to improve CS safety.
Keywords: cesarean section, surgical site infection, hospital acquired infections, antibiotic prophylaxis, epidemiology, Slovenia
Published in DiRROS: 09.12.2025; Views: 111; Downloads: 49
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