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Abstract: Treatment options of recurrent malignant gliomas are very limited and with a poor survival benefit. The results from phase II trials suggest that the combination of bevacizumab and irinotecan is beneficial. Patients and methods. The medical documentation of 19 adult patients with recurrent malignant gliomas was retrospectively reviewed. All patients received bevacizumab (10 mg/kg) and irinotecan (340 mg/m2 or 125 mg/m2) every two weeks. Patient clinical characteristics, drug toxicities, response rate, progression free survival (PFS) and overall survival (OS) were evaluated. Results. Between August 2008 and November 2011, 19 patients with recurrent malignant gliomas (median age 44.7, male 73.7%, WHO performance status 0%2) were treated with bevacizumab/irinotecan regimen. Thirteen patients had glioblastoma, 5 anaplastic astrocytoma and 1 anaplastic oligoastrocytoma. With exception of one patient, all patients had initially a standard therapy with primary resection followed by postoperative chemoradiotherapy. Radiological response was confirmed after 3 months in 9 patients (1 complete response, 8 partial responses), seven patients had stable disease and three patients have progressed. The median PFS was 6.8 months (95% confidence interval [CI]: 5.3-8.3) with six-month PFS rate 52.6%. The median OS was 7.7 months (95% CI: 6.6-8.7), while six-month and twelve-month survival rates were 68.4% and 31.6%, respectively. There were 16 cases of hematopoietic toxicity grade (G) 1-2. Non-hematopoietic toxicity was present in 14 cases, all G1-2, except for one patient with proteinuria G3. No grade 4 toxicities, no thromboembolic event and no intracranial hemorrhage were observed. Conclusions. In recurrent malignant gliomas combination of bevacizumab and irinotecan might be an active regimen with acceptable toxicity.
Keywords: recurrent malignant glioma, systemic therapy, bevacizumab
Published in DiRROS: 17.04.2024; Views: 183; Downloads: 48
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Abstract: Purpose: Chronic Fatigue Syndrome (CFS) / Myalgic Encephalomyelitis (ME) is a complex condition with debilitating symptoms that significantly impact individuals, particularly those in the working population. This study aims to investigate the effec-tiveness of Graded Exercise Therapy (GET) and Cognitive Behavioral Therapy (CBT) along with additional methods such as Graded Exercise Self-help (GES), Adaptive Pac-ing Therapy (APT), and Specialist Medical Care (SMC), in managing Chronic Fatigue Syndrome (CFS) / Myalgic Encephalomyelitis (ME) among the working population. Methods: A systematic analysis of five randomized controlled trials conducted be-tween 2013 and 2023, encompassing GET, CBT, APT, SMC, and GES was performed using PubMed.Results: The selected studies consistently demonstrate that GET positively impacts physical functioning and reduces fatigue levels in working individuals with CFS. Ad-ditionally, CBT proves valuable, emphasizing the importance of addressing the mental aspects of CFS in occupational contexts.Conclusion: This review underscores the need for further research, advocating for direct assessment methods like biomarkers to enhance our understanding of CFS and improve treatment outcomes. These insights are crucial for healthcare practitioners, researchers, and policymakers navigating the complexities of CFS within the work-place. Emphasizing the integration of psychological interventions with physical therapies is essential for a comprehensive approach to managing CFS among the working population.
Keywords: Chronic Fatigue Syndrome / Myalgic Encephalomyelitis, CFS/ME, graded exercise therapy, cognitive behavioral therapy, adaptive pacing therapy, specialist medical care, working population
Published in DiRROS: 17.04.2024; Views: 174; Downloads: 105
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Abstract: Purpose: The aim of this review was to determine the influence of physical activity on the arterial blood pressure of the elderly through a review of previous research.Methods: The search was performed on the Web of Science, Google Scholar and PubMed databases. The first search identified 1112 articles. In the initial assessment carried out in accordance with the inclusion and exclusion criteria, 15 articles were found suitable and were included in the study, while 1097 studies were excluded. The search was limited to articles published in period of 2002–2022.Results: After the applied exercise programs and evaluation at the final measure-ments, the mean values of systolic blood pressure, on the total sample, were 131 mmHg, while the values of diastolic blood pressure were 77 mmHg, which indicates that physi-cal activity (regardless of whether swimming, walking, yoga, resistance training, high interval training, Tai Chi) have a positive effect on the arterial blood pressure of the elderly.Conclusion: All studies, except one, showed a positive influence of physical activity on the arterial blood pressure of elderly people. In this regard, it can be concluded that physical activity, regardless of the type of activity, has a positive effect on the arterial blood pressure of the elderly, in the form of a reduction in blood pressure values.
Keywords: pshysical activity, arterial blood pressure, elderly
Published in DiRROS: 17.04.2024; Views: 145; Downloads: 88
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Abstract: Purpose: To assess the foot posture and hip joint mobility of elite handball and soccer players and to investigate possible correlations between these measurements. Methods: We compared the differences in means of Foot Posture Index (FPI), pas-sive hip internal (IR), and external (ER) rotation range of motion (ROM) between three groups of male subjects (17 handball players, 17 soccer players, and 16 non-athletes). The Kruskal-Walli’s test and post-hoc pairwise comparison with the Mann-Whitney U test were used to determine the differences between the group means, and associations between variables were analyzed with Spearman’s correlation coefficient. Results: No significant differences in the mean FPI were found between the soccer players (1.3 ± 2.9), handball players (0.7 ± 2.1), and the control group (1.7 ± 2.5) (p > 0.05). Similarly, no significant difference was found between the groups in the hip ER ROM. In contrast, a significantly lower (p < 0.05) hip IR ROM was observed in the soccer players (30.6° ± 5.3°) compared to the handball players (41.0° ± 8.1°) and the control group (41.1° ± 6.4°). A weak positive correlation was only observed between the FPI and hip IR ROM in the soccer players (ρ: 0.36, p = 0.035). Conclusions: Handball and soccer players show a tendency toward less pronated feet compared to non-athletes, but the differences are not significant and the mean FPI values are still within the range of normal foot posture. The range of hip IR seems to be reduced in soccer players and weakly, but significantly and positively associated with the FPI value, which needs to be further investigated in future studies.
Keywords: foot shape, hip mobility, soccer players, handball players
Published in DiRROS: 17.04.2024; Views: 174; Downloads: 95
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Abstract: Purpose Intumescent coatings are nowadays a dominant passive system used to protect structural materials in case of fire. Due to their reactive swelling behaviour, intumescent coatings are particularly complex materials to be modelled and predicted, which can be extremely useful especially for performance-based fire safety designs. In addition, many parameters influence their performance, and this challenges the definition and quantification of their material properties. Several approaches and models of various complexities are proposed in the literature, and they are reviewed and analysed in a critical literature review. Design/methodology/approach Analytical, finite-difference and finite-element methods for modelling intumescent coatings are compared, followed by the definition and quantification of the main physical, thermal, and optical properties of intumescent coatings: swelled thickness, thermal conductivity and resistance, density, specific heat capacity, and emissivity/absorptivity. Findings The study highlights the scarce consideration of key influencing factors on the material properties, and the tendency to simplify the problem into effective thermo-physical properties, such as effective thermal conductivity. As a conclusion, the literature review underlines the lack of homogenisation of modelling approaches and material properties, as well as the need for a universal modelling method that can generally simulate the performance of intumescent coatings, combine the large amount of published experimental data, and reliably produce fire-safe performance-based designs. Research limitations/implications Due to their limited applicability, high complexity and little comparability, the presented literature review does not focus on analysing and comparing different multi-component models, constituted of many model-specific input parameters. On the contrary, the presented literature review compares various approaches, models and thermo-physical properties which primarily focusses on solving the heat transfer problem through swelling intumescent systems. Originality/value The presented literature review analyses and discusses the various modelling approaches to describe and predict the behaviour of swelling intumescent coatings as fire protection for structural materials. Due to the vast variety of available commercial products and potential testing conditions, these data are rarely compared and combined to achieve an overall understanding on the response of intumescent coatings as fire protection measure. The study highlights the lack of information and homogenisation of various modelling approaches, and it underlines the research needs about several aspects related to the intumescent coating behaviour modelling, also providing some useful suggestions for future studies.
Keywords: intumescent coatings, fire protection, modelling, structural fire engineering, fire safety, performance-based design
Published in DiRROS: 17.04.2024; Views: 192; Downloads: 67
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