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Abstract: Approximately 40% of patients with diffuse large B-cell lymphoma (DLBCL) are not cured with first-line chemoimmunotherapy, resulting in poor prognosis. Schmitz et al. classified DLBCL into four prognostic genetic groups using whole-exome sequencing. We applied a simplified approach using a targeted next-generation sequencing assay (Archer FusionPlex Lymphoma Assay) to analyze samples from 105 patients—53 with a progression-free survival (PFS) < 2 years (the “Relapse group”) and 52 with a PFS > 5 years (the “Remission group”) following first-line systemic treatment. Patients were classified according to Schmitz et al. into the following categories: “MCD” (MYD88L265P and CD79B alteration), “N1” (NOTCH1 alteration), “BN2” (NOTCH2 alteration and BCL6 translocation), and “EZB” (EZH2 alteration and BCL2 translocation). The predictive value of this simplified genetic classification and of relevant clinical features were evaluated. The “Relapse group” included more patients classified as MCD and N1, while fewer were classified as EZB and BN2. Also, cell-of-origin (COO) characteristics and the size of N1 aligned with the classification of Schmitz et al. However, the limited sample size precludes definitive conclusions about the predictive value of our simplified approach. Additionally, male sex, B symptoms, and bone marrow involvement were associated with relapse. Therefore, these clinical features may be useful in predicting outcomes until an effective molecular classification is widely adopted.
Keywords: DLBCL, genetic classification, predictive, lymphoma
Published in DiRROS: 21.11.2025; Views: 104; Downloads: 29
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Abstract: In the structural analysis of fluid-conveying pipes, dynamic instabilities can occur at specific values of the flow velocity, depending on the geometry as well as the material parameters of the pipe and the interior fluid. These critical points fall into the broader category of Hopf bifurcations. Typical numerical models of this problem employ a one-dimensional weighted residual method, leading to a velocity-dependent eigenvalue problem. The solutions form eigencurves, and the critical points are characterized by eigenvalues with vanishing real parts. In this paper, we show that critical points can be computed directly as solutions to a single three-parameter eigenvalue problem. In addition, we employ a recently developed method for computing individual eigencurves, based on the concept of exponential residual relaxation. For the discretization of the weak form, we use a finite element method with a particular version of $C^1$-continuous high-order spectral elements, suited for fourth-order differential equations, and we discuss the differences compared to the more commonly used weighted residual method based on the basis functions of a linear Euler-Bernoulli beam. Four numerical examples demonstrate the effectiveness of the implemented algorithms. For verification, we provide a detailed derivation of analytical solutions for special cases.
Keywords: pipes, Euler-Bernoulli beam, stability, Hopf bifurcation, multiparameter eigenvalue problem, spectral element method
Published in DiRROS: 20.11.2025; Views: 115; Downloads: 57
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Abstract: This study examines the sense of place (SOP) and identity in peri-urban landscapes, which serve as borderscapes between urban and rural areas. It applies SOP both as a cultural ecosystem service and a phenomenological construct to explore how residents and visitors connect with these landscapes. Using a mixed-methods approach with over seven hundred participants from Ljubljana, Koper, and Kranj, Slovenia, the study maps and evaluates how residents and visitors perceive their environment. The results show that residents have a stronger SOP, but the importance of places for SOP and other cultural services is similar for both residents and visitors. Participatory mapping effectively identified areas of high SOP value, revealing strong connections to hills, bodies of water, biodiverse areas, and small settlements. Conflicts between land-use planning and local values were identified, emphasising the need for flexible, participatory spatial planning to reflect diverse, locally specific perspectives in decision-making.
Published in DiRROS: 20.11.2025; Views: 138; Downloads: 37
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Keywords: public space, research, urban planning
Published in DiRROS: 20.11.2025; Views: 148; Downloads: 47
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Abstract: Long-term monitoring of stable isotopes in precipitation (δ18O, δ2 H), alongside meteorological data, is key to understanding how large-scale hydroclimate variability influences regional and local climate. This study presents one of the longest records in Central and Southeastern Europe: the multi-decadal (1981–2024) dataset of monthly composite precipitation stable isotope records from Ljubljana, Slovenia. The δ18O, δ2 H, and d-excess values are increasing (+0.02 ‰, +0.18 ‰, and +0.05 ‰ per year, respectively), consistent with regional warming. Seasonal patterns were evident, with elevated d-excess values during autumn. The decomposition of the δ18O, δ2 H and d-excess time series using Hilbert-Huang Transform revealed statistically significant annual oscillations in all variables. These oscillations correlated strongly with the annual oscillation of temperature, but a lag of 2–3 months was identified for d-excess. Lower-frequency (multi-year) oscillations of d-excess were also observed. HYSPLIT back-trajectory analysis confirmed a significant contribution of Mediterranean-sourced air masses to autumn precipitation, but did not explain d-excess oscillations. Similar results were observed also for coastal (Portoroˇz, Slovenia) and continental (Vienna, Austria) stations. The findings imply an accelerating, exponential-like isotopic response to warming that has already propagated into the water cycle, providing isotope evidence that precipitation-surface water-groundwater interactions in investigated region changed in last decade.
Keywords: precipitation stable isotopes, trend analysis, Hilbert-Huang transform, ensemble empirical mode decomposition, HYSPLIT
Published in DiRROS: 19.11.2025; Views: 119; Downloads: 49
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