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Title:Progresivna multifokalna levkoencefalopatija po rituksimabu pri bolniku z recidivnim limfomom plaščnih celic v popolni remisiji
Authors:ID Roš-Opaškar, Tanja (Author)
ID Horvat, Matej (Author)
ID Popović, Mara (Author)
ID Jezeršek Novaković, Barbara (Author)
Files:.pdf PDF - Presentation file, download (765,92 KB)
MD5: 3AA9BC9139BD38E6704536330E2F508A
PID: 20.500.12556/dirros/f34e208b-884f-48c1-8fe8-6e3570630046
 
Language:Slovenian
Typology:1.01 - Original Scientific Article
Organization:Logo OI - Institute of Oncology
Abstract:Progresivna multifokalna levkoencefalopatija (PML) je redko in običajno smrtno demielinizacijsko obolenje možganov, ki se razvije skoraj izključno pri bolnikih z imunsko pomanjkljivostjo in je posledica reaktivacije latentne okužbe s polioma virusom JC. V zadnjih letih so opisani tudi primeri PML po zdravljenju z rituksimabom. Predstavljamo naš prvi potrjeni primer PML pri 55-letnem HIV-negativnem bolniku z recidivnim limfomom plaščnih celic, pri katerem smo raka uspešno zdravili s kemoterapijo in rituksimabom ter z avtologno presaditvijo perifernih krvotvornih matičnih celic (PKMC). S primerom želimo opozoriti na pomembnost PML v diferencialni diagnozi pri bolnikih z napredujočo nevrološko simptomatiko in imunsko pomanjkljivostjo po zdravljenju limfoma z rituksimabom ter pomembnost zgodnjega prepoznavanja te bolezni z dokazom JC-virusne okužbe v likvorju ali v vzorcu stereotaktične biopsije možganov.
Publication status:Published
Publication version:Version of Record
Year of publishing:2012
Number of pages:str. 48-51, 56
Numbering:Letn. 16, št. 1
PID:20.500.12556/DiRROS-8628 New window
UDC:616.15-006.6-08-06:616.831
ISSN on article:1408-1741
URN:URN:NBN:SI:doc-9M4PZWBN
COBISS.SI-ID:1320571 New window
Copyright:by Authors
Note:Soavtorji: Matej Horvat, Mara Popović, Barbara Jezeršek Novaković;
Publication date in DiRROS:31.08.2018
Views:4296
Downloads:1034
Metadata:XML DC-XML DC-RDF
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ROŠ-OPAŠKAR, Tanja, HORVAT, Matej, POPOVIĆ, Mara and JEZERŠEK NOVAKOVIĆ, Barbara, 2012, Progresivna multifokalna levkoencefalopatija po rituksimabu pri bolniku z recidivnim limfomom plaščnih celic v popolni remisiji. Onkologija [online]. 2012. Vol. 16, no. 1, p. 48–51, 56. [Accessed 27 April 2025]. Retrieved from: https://dirros.openscience.si/IzpisGradiva.php?lang=eng&id=8628
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Record is a part of a journal

Title:Onkologija
Shortened title:Onkologija
Publisher:Onkološki inštitut
ISSN:1408-1741
COBISS.SI-ID:65324032 New window

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:31.08.2018

Secondary language

Language:English
Title:Progressive multifocal leukoencephalopathy following rituximab therapy in a patient with a relapsed mantle cell lymphoma in complete remission
Abstract:Progressive multifocal leukoencephalopathy (PML) is a rare and usually fatal demyelinating disease of the brain that is developed almost exclusively in patients with immunodeficiency and is a result of a latent infection with the JC polyomavirus. In recent years, several cases of PML have been reported following rituximab therapy. We present our first confirmed case of PML in a 55-year-old HIV-negative patient with a relapsed mantle cell lymphoma who was treated successfully with chemotherapy, rituximab and autologous transplantation of peripheral haematopoietic stem cells (PHSC). By reporting this case we wish to draw attention to the importance of PML in differential diagnosis of patients with a progressing neurological symptoms and immunodeficiency following lymphoma treatment with rituximab and stress the importance of early detection of this disease with evidence of JC virus infection in the cerebrospinal fluid or stereotactic brain biopsy sample.


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