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Naslov:Effect of poly-[alpha], [gamma], L-glutamic acid as a capping agent on morphology and oxidative stress-dependent toxicity of silver nanoparticles
Avtorji:ID Stevanović, Magdalena (Avtor)
ID Kovačević, Branimir (Avtor)
ID Nunić, Jana (Avtor)
ID Filipič, Metka (Avtor)
ID Uskoković, Dragan (Avtor)
Datoteke:URL URL - Izvorni URL, za dostop obiščite http://dx.doi.org/10.2147/IJN.S24889
 
.pdf PDF - Predstavitvena datoteka, prenos (2,23 MB)
MD5: 3E6433669FF18268A146B09B229227B1
 
Jezik:Angleški jezik
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:Logo NIB - Nacionalni inštitut za biologijo
Povzetek:Highly stable dispersions of nanosized silver particles were synthesized using a straightforward, cost-effective, and ecofriendly method. Nontoxic glucose was utilized as a reducing agent and poly- α, γ, L-glutamic acid (PGA), a naturally occurring anionic polymer, was used as a capping agent to protect the silver nanoparticles from agglomeration and render them biocompatible. Use of ammonia during synthesis was avoided. Our study clearly demonstrates how the concentration of the capping agent plays a major role in determining the dimensions, morphology, and stability, as well as toxicity of a silver colloidal solution. Hence, proper optimization is necessary to develop silver colloids of narrow size distribution. The samples were characterized by Fourier transform infrared spectroscopy, ultraviolet-visible spectroscopy, field-emission scanning electron microscopy, transmission electron microscopy, and zeta potential measurement. MTT assay results indicated good biocompatibility of the PGA-capped silver nanoparticles. Formation of intracellular reactive oxygen species was measured spectrophotometrically using 2,7-dichlorofluorescein diacetate as a fluorescent probe, and it was shown that the PGA-capped silver nanoparticles did not induce intracellular formation of reactive oxygen species.
Ključne besede:green synthesis, morphology, cytotoxicity
Status publikacije:Objavljeno
Verzija publikacije:Objavljena publikacija
Datum objave:15.11.2011
Leto izida:2011
Št. strani:str. 2837-2847
Številčenje:Vol. 6
PID:20.500.12556/DiRROS-20049 Novo okno
UDK:577
ISSN pri članku:1178-2013
DOI:10.2147/IJN.S24889 Novo okno
COBISS.SI-ID:2459983 Novo okno
Datum objave v DiRROS:05.08.2024
Število ogledov:482
Število prenosov:268
Metapodatki:XML DC-XML DC-RDF
:
STEVANOVIĆ, Magdalena, KOVAČEVIĆ, Branimir, NUNIĆ, Jana, FILIPIČ, Metka in USKOKOVIĆ, Dragan, 2011, Effect of poly-[alpha], [gamma], L-glutamic acid as a capping agent on morphology and oxidative stress-dependent toxicity of silver nanoparticles. International journal of nanomedicine [na spletu]. 2011. Vol. 6, p. 2837–2847. [Dostopano 12 april 2025]. DOI 10.2147/IJN.S24889. Pridobljeno s: https://dirros.openscience.si/IzpisGradiva.php?lang=slv&id=20049
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Gradivo je del revije

Naslov:International journal of nanomedicine
Založnik:Dove Medical Press
ISSN:1178-2013
COBISS.SI-ID:3223828 Novo okno

Gradivo je financirano iz projekta

Financer:MESTD - Ministry of Education, Science and Technological Development of Republic of Serbia
Številka projekta:III45004
Naslov:Molecular designing of nanoparticles with controlled morphological and physicochemical characteristics and functional materials based on them

Licence

Licenca:CC BY-NC 3.0, Creative Commons Priznanje avtorstva-Nekomercialno 3.0 Nedoločena
Povezava:https://creativecommons.org/licenses/by-nc/3.0/deed.sl
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