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Title:The influence of genetic variability in IL1B and MIR146A on the risk of pleural plaques and malignant mesothelioma
Authors:ID Piber, Petra (Author)
ID Vavpetič, Neža (Author)
ID Goričar, Katja (Author)
ID Dolžan, Vita (Author)
ID Kovač, Viljem (Author)
ID Franko, Alenka (Author)
Files:.pdf PDF - Presentation file, download (327,61 KB)
MD5: EF5BC2854BD308012996FC7221D7C79C
 
Language:English
Typology:1.01 - Original Scientific Article
Organization:Logo OI - Institute of Oncology
Abstract:Asbestos exposure is associated with the development of pleural plaques as well as malignant mesothelioma (MM). Asbestos fibres activate macrophages, leading to the release of inflammatory mediators including interleukin 1 beta (IL-1%). The expression of IL-1% may be influenced by genetic variability of IL1B gene or regulatory microRNAs (miRNAs). This study investigated the effect of polymorphisms in IL1B and MIR146A genes on the risk of developing pleural plaques and MM. Subjects and methods. In total, 394 patients with pleural plaques, 277 patients with MM, and 175 healthy control subjects were genotyped for IL1B and MIR146A polymorphisms. Logistic regression was used in statistical analysis. Results. We found no association between MIR146A and IL1B genotypes, and the risk of pleural plaques. MIR146A rs2910164 was significantly associated with a decreased risk of MM (OR = 0.31, 95% CI = 0.13%0.73, p = 0.008). Carriers of two polymorphic alleles had a lower risk of developing MM, even after adjustment for gender and age (OR = 0.34, 95% CI = 0.14%0.85, p = 0.020). Among patients with known asbestos exposure, carriers of at least one polymorphic IL1B rs1143623 allele also had a lower risk of MM in multivariable analysis (OR = 0.50, 95% CI = 0.28%0.92, p = 0.025). The interaction between IL1B rs1143623 and IL1B rs1071676 was significantly associated with an increased risk of MM (p = 0.050). Conclusions. Our findings suggest that genetic variability of inflammatory mediator IL-1% could contribute to the risk of developing MM, but not pleural plaques.
Keywords:asbestos, genetic variation, malignant mesothelioma, pleural plaques
Publication status:Published
Publication version:Version of Record
Publication date:01.01.2020
Publisher:Association of Radiology and Oncology
Year of publishing:2020
Number of pages:str. 429-436, V
Numbering:Vol. 54, no. 4
Source:Ljubljana
PID:20.500.12556/DiRROS-19353 New window
UDC:616.2
ISSN on article:1318-2099
DOI:10.2478/raon-2020-0057 New window
COBISS.SI-ID:31426819 New window
Copyright:by Authors
Publication date in DiRROS:16.07.2024
Views:630
Downloads:134
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:
PIBER, Petra, VAVPETIČ, Neža, GORIČAR, Katja, DOLŽAN, Vita, KOVAČ, Viljem and FRANKO, Alenka, 2020, The influence of genetic variability in IL1B and MIR146A on the risk of pleural plaques and malignant mesothelioma. Radiology and oncology [online]. 2020. Vol. 54, no. 4, p. 429–436, v. [Accessed 23 April 2025]. DOI 10.2478/raon-2020-0057. Retrieved from: https://dirros.openscience.si/IzpisGradiva.php?lang=eng&id=19353
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Record is a part of a journal

Title:Radiology and oncology
Shortened title:Radiol. oncol.
Publisher:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 New window

Secondary language

Language:Slovenian
Keywords:azbest, genetske variacije, maligni mezoteliom, plevralni izlivi


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