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Naslov:Synthetic cannabinoid WIN 55,212–2 inhibits growth and induces cell death of oral and pancreatic stem-like/poorly differentiated tumor cells
Avtorji:ID Ko, Meng-Wei (Avtor)
ID Breznik, Barbara (Avtor)
ID Senjor, Emanuela (Avtor)
ID Jewett, Anahid (Avtor)
Datoteke:URL URL - Izvorni URL, za dostop obiščite https://doi.org/10.1016/j.adcanc.2022.100043
 
.pdf PDF - Predstavitvena datoteka, prenos (8,37 MB)
MD5: 8BB1161F766362CA48EE4276CE48335F
 
Jezik:Angleški jezik
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:Logo NIB - Nacionalni inštitut za biologijo
Povzetek:We report here that synthetic cannabinoid WIN 55,212–2 inhibits tumor cell proliferation and induces cell death of oral and pancreatic tumor cells, and the effect is much more pronounced on stem-like/poorly differentiated OSCSCs and MP2 cells when compared to well-differentiated OSCCs, and PL-12 tumor cells. In addition, WIN 55,212-2 decreases cell surface expression of CD44, CD54, MHC class I and PD-L1 on oral and pancreatic tumor cells with the exception of PD-L1 expression on well-differentiated PL-12 pancreatic tumor cells which exhibits an increase in the expression rather than a decrease. Overall, we demonstrate that WIN 55,212-2 has an increased targeting activity against cancer stem cells/poorly differentiated oral and pancreatic tumor cells when compared to well-differentiated tumor cells, and furthermore, such differences in function do not correlate with the levels of CB1 and CB2 receptor expression on tumor cells, suggesting it's function either through post-receptor mediated activation and/or yet-to-be identified novel receptors. Intraperitoneal (IP) delivery of WIN 55-212-2 in humanized BLT mice is found to impart an activating potential for NK cells demonstrating increased NK cell mediated cytotoxicity and secretion of IFN-γ in our preliminary experiments. These results not only suggest a direct targeting of CSCs/poorly differentiated tumors by WIN 55-212-2 but also by indirect targeting of such tumors through the activation and increased functions of NK cells.
Ključne besede:cancer stem cells, cannabinoids, cell death, cancer biology, genetic toxicology
Status publikacije:Objavljeno
Verzija publikacije:Objavljena publikacija
Datum objave:01.10.2022
Leto izida:2022
Št. strani:str. [1]-10
Številčenje:Vol. 5
PID:20.500.12556/DiRROS-19322 Novo okno
UDK:575
ISSN pri članku:2667-3940
DOI:10.1016/j.adcanc.2022.100043 Novo okno
COBISS.SI-ID:113550595 Novo okno
Opomba:Ostali avtorji: Barbara Breznik, Emanuela Senjor, Anahid Jewett; Nasl. z nasl. zaslona; Opis vira z dne 1. 7. 2022;
Datum objave v DiRROS:17.07.2024
Število ogledov:524
Število prenosov:281
Metapodatki:XML DC-XML DC-RDF
:
KO, Meng-Wei, BREZNIK, Barbara, SENJOR, Emanuela in JEWETT, Anahid, 2022, Synthetic cannabinoid WIN 55,212–2 inhibits growth and induces cell death of oral and pancreatic stem-like/poorly differentiated tumor cells. Advances in cancer biology : Metastasis [na spletu]. 2022. Vol. 5, p. 1–10. [Dostopano 6 april 2025]. DOI 10.1016/j.adcanc.2022.100043. Pridobljeno s: https://dirros.openscience.si/IzpisGradiva.php?lang=slv&id=19322
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Gradivo je del revije

Naslov:Advances in cancer biology : Metastasis
Založnik:Elsevier B.V.
ISSN:2667-3940
COBISS.SI-ID:87457795 Novo okno

Licence

Licenca:CC BY-NC-ND 4.0, Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by-nc-nd/4.0/deed.sl
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Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:rakave matične celice, kanabinoidi, celična smrt, biologija raka, genetska toksikologija


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