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Title:Infiltrating natural killer cells bind, lyse and increase chemotherapy efficacy in glioblastoma stem-like tumorospheres
Authors:ID Breznik, Barbara (Author)
ID Ko, Meng-Wei (Author)
ID Tse, Christopher (Author)
ID Chen, Po-Chun (Author)
ID Senjor, Emanuela (Author)
ID Majc, Bernarda (Author)
ID Habič, Anamarija (Author)
ID Angelillis, Nicolas (Author)
ID Novak, Metka (Author)
ID Župunski, Vera (Author)
ID Mlakar, Jernej (Author)
ID Nathanson, David (Author)
ID Jewett, Anahid (Author)
Files:URL URL - Source URL, visit https://doi.org/10.1038/s42003-022-03402-z
 
URL URL - Source URL, visit https://www.arrs.si/sl/promocija/odlicni/inc/22/odlicni-22-3.pdf
 
.pdf PDF - Presentation file, download (10,81 MB)
MD5: 916522731EC60E747674F15A420F7970
 
Language:English
Typology:1.01 - Original Scientific Article
Organization:Logo NIB - National Institute of Biology
Logo IJS - Jožef Stefan Institute
Abstract:Glioblastomas remain the most lethal primary brain tumors. Natural killer (NK) cell-based therapy is a promising immunotherapeutic strategy in the treatment of glioblastomas, since these cells can select and lyse therapy-resistant glioblastoma stem-like cells (GSLCs). Immunotherapy with super-charged NK cells has a potential as antitumor approach since we found their efficiency to kill patient-derived GSLCs in 2D and 3D models, potentially reversing the immunosuppression also seen in the patients. In addition to their potent cytotoxicity, NK cells secrete IFN-γ, upregulate GSLC surface expression of CD54 and MHC class I and increase sensitivity of GSLCs to chemotherapeutic drugs. Moreover, NK cell localization in peri-vascular regions in glioblastoma tissues and their close contact with GSLCs in tumorospheres suggests their ability to infiltrate glioblastoma tumors and target GSLCs. Due to GSLC heterogeneity and plasticity in regards to their stage of differentiation personalized immunotherapeutic strategies should be designed to effectively target glioblastomas.
Keywords:glioblastoma, natural killer cells, translational oncology
Publication status:Published
Publication version:Version of Record
Publication date:10.05.2022
Year of publishing:2022
Number of pages:str. 1-15
Numbering:Vol. 5
PID:20.500.12556/DiRROS-19321 New window
UDC:616-006
ISSN on article:2399-3642
DOI:10.1038/s42003-022-03402-z New window
COBISS.SI-ID:107677443 New window
Note:Nasl. z nasl. zaslona; Opis vira z dne 13. 5. 2022; Ostali avtorji: Meng-Wei Ko, Christopher Tse, Po-Chun Chen, Emanuela Senjor, Bernarda Majc, Anamarija Habič, Nicolas Angelillis, Metka Novak, Vera Župunski, Jernej Mlakar, David Nathanson & Anahid Jewett;
Publication date in DiRROS:16.07.2024
Views:580
Downloads:427
Metadata:XML DC-XML DC-RDF
:
BREZNIK, Barbara, KO, Meng-Wei, TSE, Christopher, CHEN, Po-Chun, SENJOR, Emanuela, MAJC, Bernarda, HABIČ, Anamarija, ANGELILLIS, Nicolas, NOVAK, Metka, ŽUPUNSKI, Vera, MLAKAR, Jernej, NATHANSON, David and JEWETT, Anahid, 2022, Infiltrating natural killer cells bind, lyse and increase chemotherapy efficacy in glioblastoma stem-like tumorospheres. Communications biology [online]. 2022. Vol. 5, p. 1–15. [Accessed 18 April 2025]. DOI 10.1038/s42003-022-03402-z. Retrieved from: https://dirros.openscience.si/IzpisGradiva.php?lang=eng&id=19321
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Record is a part of a journal

Title:Communications biology
Shortened title:Commun. biolog.
Publisher:Springer Nature
ISSN:2399-3642
COBISS.SI-ID:5134671 New window

Document is financed by a project

Funder:ARIS - Slovenian Research and Innovation Agency
Project number:P1-0245-2019
Name:Ekotoksiologija, toksikološka genomika in karcinogeneza
Funder:ARIS - Slovenian Research and Innovation Agency
Project number:P1-0207-2020
Name:Toksini in biomembrane
Funder:ARIS - Slovenian Research and Innovation Agency
Project number:J3-8201-2017
Name:Okvare jedrnega transporta pri nevrodegenerativnih boleznih
Funder:ARIS - Slovenian Research and Innovation Agency
Project number:Z3-1870-2019
Name:Vpliv mezenhimskih matičnih celic na odpornost glioblastoma na terapijo

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

Language:Slovenian
Keywords:glioblastom, naravne celice ubijalke, translacijska onkologija


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