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Title:Care of patients with non-small-cell lung cancer stage III : the Central European real-world experience
Authors:ID Zemanova, Milada (Author)
ID Pirker, Robert (Author)
ID Petruželka, Luboš (Author)
ID Zbozínkova, Zuzana (Author)
ID Rajer, Mirjana (Author)
ID Bogos, Krisztina (Author)
ID Purkalne, Gunta (Author)
ID Ceriman, Vesna (Author)
ID Chaudhary, Subhash (Author)
ID Richter, Igor (Author)
Files:URL URL - Source URL, visit https://content.sciendo.com/view/journals/raon/54/2/article-p209.xml
 
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MD5: 76DCE58764E1BB9109A2FACA3AFF0C85
 
Language:English
Typology:1.01 - Original Scientific Article
Organization:Logo OI - Institute of Oncology
Abstract:Background. Management of non-small-cell lung cancer (NSCLC) is affected by regional specificities. The present study aimed at determining diagnostic and therapeutic procedures including outcome of patients with NSCLC stage III in the realworld setting in Central European countries to define areas for improvements. Patients and methods. This multicentre, prospective and non-interventional study collected data of patients with NSCLC stage III in a web-based registry and analysed them centrally. Results. Between March 2014 and March 2017, patients (n=583) with the following characteristics were entered: 32% females, 7% never-smokers; ECOG performance status (PS) 0, 1, 2 and 3 in 25%, 58%, 12% and 5%, respectively; 21% prior weight loss; 53% squamous carcinoma, 38% adenocarcinoma; 10% EGFR mutations. Staging procedures included chest X-ray (97% of patients), chest CT (96%), PET-CT (27%), brain imaging (20%), bronchoscopy (89%), endobronchial ultrasound (EBUS) (13%) and CT-guided biopsy (9%). Stages IIIA/IIIB were diagnosed in 55%/45% of patients, respectively. N2/N3 nodes were diagnosed in 60%/23% and pathologically confirmed in 29% of patients. Most patients (56%) were treated by combined modalities. Surgery plus chemotherapy was administered to 20%, definitive chemoradiotherapy to 34%, chemotherapy only to 26%, radiotherapy only to 12% and best supportive care (BSC) to 5% of patients. Median survival and progression-free survival times were 16.8 (15.3;18.5) and 11.2 (10.2;12.2) months, respectively. Stage IIIA, female gender, no weight loss, pathological mediastinal lymph node verification, surgery and combined modality therapy were associated with longer survival. Conclusions. The real-world study demonstrated a broad heterogeneity in the management o f stage III NSCLC in Central European countries and suggested to increase the rates of PET-CT imaging, brain imaging and invasive mediastinal staging.
Keywords:diagnostic procedures, multimodality treatment, non-small-cell cancer, lung cancer
Publication status:Published
Publication version:Version of Record
Publication date:01.06.2020
Publisher:Association of Radiology and Oncology
Year of publishing:2020
Number of pages:str. 209-220, IX
Numbering:Vol. 54, no. 2
Source:Ljubljana
PID:20.500.12556/DiRROS-19293 New window
UDC:616.2
ISSN on article:1318-2099
COBISS.SI-ID:23064579 New window
Copyright:by Authors
Publication date in DiRROS:12.07.2024
Views:499
Downloads:275
Metadata:XML DC-XML DC-RDF
:
ZEMANOVA, Milada, PIRKER, Robert, PETRUŽELKA, Luboš, ZBOZÍNKOVA, Zuzana, RAJER, Mirjana, BOGOS, Krisztina, PURKALNE, Gunta, CERIMAN, Vesna, CHAUDHARY, Subhash and RICHTER, Igor, 2020, Care of patients with non-small-cell lung cancer stage III : the Central European real-world experience. Radiology and oncology [online]. 2020. Vol. 54, no. 2, p. 209–220, ix. [Accessed 3 April 2025]. Retrieved from: https://dirros.openscience.si/IzpisGradiva.php?lang=eng&id=19293
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Record is a part of a journal

Title:Radiology and oncology
Shortened title:Radiol. oncol.
Publisher:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 New window

Secondary language

Language:Slovenian
Keywords:klinična praksa, multimodalno zdravljenje, nedrobnocelični rak, rak pljuč


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