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Title:Adjuvant TNF-a therapy to electrochemotherapy with intravenous cisplatin in murine sarcoma exerts synergistic antitumor effectiveness
Authors:ID Čemažar, Maja (Author)
ID Todorović, Vesna (Author)
ID Ščančar, Janez (Author)
ID Lampreht Tratar, Urša (Author)
ID Savarin, Monika (Author)
ID Kamenšek, Urška (Author)
ID Kranjc Brezar, Simona (Author)
ID Cör, Andrej (Author)
ID Serša, Gregor (Author)
Files:.pdf PDF - Presentation file, download (978,26 KB)
MD5: 92B5D53995D5575313240A58D2D6CE45
 
Language:English
Typology:1.01 - Original Scientific Article
Organization:Logo OI - Institute of Oncology
Abstract:Background. Electrochemotherapy is a tumour ablation modality, based on electroporation of the cell membrane, allowing non-permeant anticancer drugs to enter the cell, thus augmenting their cytotoxicity by orders of magnitude. In preclinical studies, bleomycin and cisplatin proved to be the most suitable for clinical use. Intravenous administration of cisplatin for electrochemotherapy is still not widely accepted in the clinics, presumably due to its lower antitumor effectiveness, but adjuvant therapy by immunomodulatory or vascular-targeting agents could provide a way for its potentiation. Hence, the aim of the present study was to explore the possibility of adjuvant tumour necrosis factor % (TNF-%) therapy to potentiate antitumor effectiveness of electrochemotherapy with intravenous cisplatin administration in murine sarcoma. Materials and methods. In vivo study was designed to evaluate the effect of TNF-% applied before or after the electrochemotherapy and to evaluate the effect of adjuvant TNF-% on electrochemotherapy with different cisplatin doses. Results. A synergistic interaction between TNF-% and electrochemotherapy was observed. Administration of TNF-% before the electrochemotherapy resulted in longer tumour growth delay and increased tumour curability, and was significantly more effective than TNF-% administration after the electrochemotherapy. Tumour analysis revealed increased platinum content in tumours, TNF-% induced blood vessel damage and increased tumour necrosis after combination of TNF-% and electrochemotherapy, indicating an anti-vascular action of TNF-%. In addition, immunomodulatory effect might have contributed to curability rate of the tumours. Conclusion. Adjuvant intratumoural TNF-% therapy synergistically contributes to electrochemotherapy with intravenous cisplatin administration. Due to its potentiation at all doses of cisplatin, the combined treatment is predicted to be effective also in tumours, where the drug concentration is suboptimal or in bigger tumours, where electrochemotherapy with intravenous cisplatin is not expected to be sufficiently effective.
Keywords:electrochemotherapy, TNF, adjuvant immunotherapy, cisplatin
Publication status:Published
Publication version:Version of Record
Publication date:01.03.2015
Publisher:Association of Radiology and Oncology
Year of publishing:2015
Number of pages:str. 32-40, III
Numbering:Vol. 49, no. 1
Source:Ljubljana
PID:20.500.12556/DiRROS-18726 New window
UDC:602.6/.7
ISSN on article:1318-2099
DOI:10.1515/raon-2015-0005 New window
COBISS.SI-ID:1975163 New window
Copyright:by Authors
Publication date in DiRROS:17.04.2024
Views:881
Downloads:214
Metadata:XML DC-XML DC-RDF
:
ČEMAŽAR, Maja, TODOROVIĆ, Vesna, ŠČANČAR, Janez, LAMPREHT TRATAR, Urša, SAVARIN, Monika, KAMENŠEK, Urška, KRANJC BREZAR, Simona, CÖR, Andrej and SERŠA, Gregor, 2015, Adjuvant TNF-a therapy to electrochemotherapy with intravenous cisplatin in murine sarcoma exerts synergistic antitumor effectiveness. Radiology and oncology [online]. 2015. Vol. 49, no. 1, p. 32–40, iii. [Accessed 10 April 2025]. DOI 10.1515/raon-2015-0005. Retrieved from: https://dirros.openscience.si/IzpisGradiva.php?lang=eng&id=18726
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Record is a part of a journal

Title:Radiology and oncology
Shortened title:Radiol. oncol.
Publisher:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 New window

Secondary language

Language:Slovenian
Keywords:elektrokemoterapija, tumorski nekrotizirajoči faktor, intravenska elektrokemoterapija, dopolnilna imunska terapija


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