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Naslov:Cancer cachexia-anorexia syndrome and skeletal muscle wasting
Avtorji:ID Jurdana, Mihaela (Avtor)
Datoteke:.pdf PDF - Predstavitvena datoteka, prenos (106,86 KB)
MD5: 0408D5291FB5755C341FD130B3912CC5
 
Jezik:Angleški jezik
Tipologija:1.02 - Pregledni znanstveni članek
Organizacija:Logo OI - Onkološki inštitut Ljubljana
Povzetek:Cachexia-anorexia syndrome is a common and important indicator of cancer. It occurs in 30% to 80% of cancer patients. Cachexia means "bad condition" and may be present in the early stages of tumor growth, before any signs of malignancy. Cancer cachexia is a syndrome of progressive body wasting, characterized by loss of adipose tissue and skeletal muscle mass. In most cancer patients, cachexia is characteriyed by anorexia, which implies a failure of food intake, regulated through a complex system of hormones and neuropeptides. A decline in food intake relative to energy expenditure is a fundamental physiologic derangement leading to cancer associated weight loss. The weight loss in patients with cachexia-anorexia syndrome differs from that in caloric starvation or anorexia nervosa. The pathophysiology of cancer cachexia is not fully understood; however, studies have shown that cytokines are important in the alteration of the carbohydrate, lipid and protein metabolism. Cancer, prolonged bed rest, HIV infection and aging are conditionsin which muscle wasting is a common feature. An intervention that may potentially attenuate the progression of muscle wasting in cancer patientsis resistance exercise training, defined as multiple repetitions of static or dynamic muscular contractions that increase muscle mass. The main components of the pathological state of cachexia are anorexia and metabolic abnormalities such as fat depletion and muscle protein catabolism. Future developments may concentrate on the molecular abnormalities of cachexia and on examination of the functional benefit of resistance exercise training for cancer related muscle wasting.
Ključne besede:cancer cachexia, muscle wasting, cytokines, muscle
Status publikacije:Objavljeno
Verzija publikacije:Objavljena publikacija
Datum objave:01.01.2009
Založnik:Association of Radiology and Oncology
Leto izida:2009
Št. strani:str. 65-75, I
Številčenje:Vol. 43, no. 2
Izvor:Ljubljana
PID:20.500.12556/DiRROS-18367 Novo okno
UDK:616-006
ISSN pri članku:1318-2099
DOI:10.2478/v10019-009-0007-y Novo okno
COBISS.SI-ID:1605331 Novo okno
Avtorske pravice:by Authors
Datum objave v DiRROS:08.03.2024
Število ogledov:610
Število prenosov:166
Metapodatki:XML DC-XML DC-RDF
:
JURDANA, Mihaela, 2009, Cancer cachexia-anorexia syndrome and skeletal muscle wasting. Radiology and oncology [na spletu]. 2009. Vol. 43, no. 2, p. 65–75, i. [Dostopano 4 april 2025]. DOI 10.2478/v10019-009-0007-y. Pridobljeno s: https://dirros.openscience.si/IzpisGradiva.php?lang=slv&id=18367
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Gradivo je del revije

Naslov:Radiology and oncology
Skrajšan naslov:Radiol. oncol.
Založnik:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 Novo okno

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Jezik:Slovenski jezik
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