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Title:Cancer cachexia-anorexia syndrome and skeletal muscle wasting
Authors:ID Jurdana, Mihaela (Author)
Files:.pdf PDF - Presentation file, download (106,86 KB)
MD5: 0408D5291FB5755C341FD130B3912CC5
 
Language:English
Typology:1.02 - Review Article
Organization:Logo OI - Institute of Oncology
Abstract:Cachexia-anorexia syndrome is a common and important indicator of cancer. It occurs in 30% to 80% of cancer patients. Cachexia means "bad condition" and may be present in the early stages of tumor growth, before any signs of malignancy. Cancer cachexia is a syndrome of progressive body wasting, characterized by loss of adipose tissue and skeletal muscle mass. In most cancer patients, cachexia is characteriyed by anorexia, which implies a failure of food intake, regulated through a complex system of hormones and neuropeptides. A decline in food intake relative to energy expenditure is a fundamental physiologic derangement leading to cancer associated weight loss. The weight loss in patients with cachexia-anorexia syndrome differs from that in caloric starvation or anorexia nervosa. The pathophysiology of cancer cachexia is not fully understood; however, studies have shown that cytokines are important in the alteration of the carbohydrate, lipid and protein metabolism. Cancer, prolonged bed rest, HIV infection and aging are conditionsin which muscle wasting is a common feature. An intervention that may potentially attenuate the progression of muscle wasting in cancer patientsis resistance exercise training, defined as multiple repetitions of static or dynamic muscular contractions that increase muscle mass. The main components of the pathological state of cachexia are anorexia and metabolic abnormalities such as fat depletion and muscle protein catabolism. Future developments may concentrate on the molecular abnormalities of cachexia and on examination of the functional benefit of resistance exercise training for cancer related muscle wasting.
Keywords:cancer cachexia, muscle wasting, cytokines, muscle
Publication status:Published
Publication version:Version of Record
Publication date:01.01.2009
Publisher:Association of Radiology and Oncology
Year of publishing:2009
Number of pages:str. 65-75, I
Numbering:Vol. 43, no. 2
Source:Ljubljana
PID:20.500.12556/DiRROS-18367 New window
UDC:616-006
ISSN on article:1318-2099
DOI:10.2478/v10019-009-0007-y New window
COBISS.SI-ID:1605331 New window
Copyright:by Authors
Publication date in DiRROS:08.03.2024
Views:634
Downloads:171
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:
JURDANA, Mihaela, 2009, Cancer cachexia-anorexia syndrome and skeletal muscle wasting. Radiology and oncology [online]. 2009. Vol. 43, no. 2, p. 65–75, i. [Accessed 6 April 2025]. DOI 10.2478/v10019-009-0007-y. Retrieved from: https://dirros.openscience.si/IzpisGradiva.php?lang=eng&id=18367
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Record is a part of a journal

Title:Radiology and oncology
Shortened title:Radiol. oncol.
Publisher:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 New window

Secondary language

Language:Slovenian
Title:Sindrom rakave kaheksije-anoreksije in izguba skeletno mišične mase


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