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Title: The role of p38 MAP kinase in cancer cell apoptosis Authors: ID Lenassi, Metka (Author) ID Plemenitaš, Ana (Author) Files: PDF - Presentation file, download (111,32 KB) MD5: A6FFE72436810F3593C231688B1EF3E4   Language: English Typology: 1.02 - Review Article Organization: OI - Institute of Oncology Abstract: Background. Cellular behaviour in response to many extracellular stimuli is mediated through MAP kinase signalling pathways. p38 MAP kinase that is represented in mammals by four isoforms (p38alfa, p38beta, p38gama and p38delta) is one of the four main subgroups of MAP kinases. Recent studies show that p38 activation is necessary for cancer cell death initiated by variety of anti-cancer agents. This finding connected cancer therapies previously considered to be mechanistically unrelated and raised the possibility of developing anti-cancer agents that lack the side effects causedby events upstream of p38 MAPK Many of the details of p38 induced apoptosis still need to be elucidated. Since most of the past studies rely only on the cell culture models, all the results have to be verified using in vivo models. Also very little is known about the role of p38 mediated apoptosis on non-neoplastic cells in response to anti-cancer agents. Conclusion. Although p38 activation of cancer cell apoptosis is a very complexprocess, recent studies indicate a good starting point for new strategies that would increase the efficiency and decrease the toxicity of proven therapies. Publication status: Published Publication version: Version of Record Publication date: 01.01.2006 Publisher: Association of Radiology and Oncology Year of publishing: 2006 Number of pages: str. 51-56 Numbering: Letn. 40, št. 1 Source: Ljubljana PID: 20.500.12556/DiRROS-18191  UDC: 616-006 ISSN on article: 1318-2099 COBISS.SI-ID: 21116889  Copyright: by Authors Note: BSDOCID122314; Publication date in DiRROS: 15.02.2024 Views: 137 Downloads: 27 Metadata:     Cite this work Plain text BibTeX EndNote XML EndNote/Refer RIS ABNT ACM Ref AMA APA Chicago 17th Author-Date Harvard IEEE ISO 690 MLA Vancouver : Copy citation

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Record is a part of a journal

Title:	Radiology and oncology
Shortened title:	Radiol. oncol.
Publisher:	Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:	1318-2099
COBISS.SI-ID:	32649472

Secondary language

Language:	Slovenian
Title:	[Vloga p38 MAP kinaze pri apoptozi rakavih celic]
Abstract:	Izhodišča. Odzivanje celic na številne zunajcelične signale poteka preko aktivacije MAP kinaznih signalnih poti. Ena od štirih glavnih podskupin MAP kinaz je p38 MAP kinaza, ki je pri sesalcih prisotna v štirih izooblikah: p38alfa, p38beta, p38gama in p38delta. Nedavne raziskave so pokazale, da je zaaktivacijo apoptoze rakavih celic z različnimi kemoterapevtiki nujna aktivacija p38 kinaze. To spoznanje je v eni točki povezalo poti delovanja raznolikih kemoterapevtikov ter s tem nakazalo nove možnosti njihovega razvojabrez stranskih učinkov, ki jih sedaj povzročajo dogodki pred aktivacijop38. Veliko podrobnosti o p38 posredovani apoptozi je potrebno še razjasniti. Dosedanja dognanja je potrebno preveriti v in vivo modelih, saj seta sedaj nanašajo predvsem na celične kulture. Malo je znanega tudi o vlogi p38 pri apoptozi nerakavih celic po aktivaciji s kemoterapevtiki. Zaključki. Čeprav je p38 posredovana aktivacija apoptoze rakavih celic zelo kompleksen proces, novejše študije ponujajo dober začetek za razvoj novih kemoterapevtikov s povečano učinkovitostjo in zmanjšano toksičnostjo.

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