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Title: The dimethylhydrazine induced colorectal tumours in rat - experimental colorectal carcinogenesis Authors: ID Perše, Martina (Author) ID Cerar, Anton (Author) Files: PDF - Presentation file, download (271,30 KB) MD5: 88A5654EAB5D15EDB6C5F98E0BD7D64E   Language: English Typology: 1.02 - Review Article Organization: OI - Institute of Oncology Abstract: Animal models of colorectal carcinogenesis represent invaluable research tool for investigating colorectal cancer (CRC). Experimentally induced tumours in laboratory animals provide opportunity for studying certain aspects of tumoursthat cannot be effectively studied in humans. Significant information on human CRC aetiology or factors influencing it has derived from studies using dimethylhydrazine (DMH) model that is one of the experimental models appreciated for its morphological similarity to human CRC. Today, DMH model represents useful research tool for the studies of colon carcinogens and chemopreventive agents. The review offers insight into morphogenesis and genetic alterations of DMH induced colorectal epithelial tumours in rats. Publication status: Published Publication version: Version of Record Publication date: 01.01.2005 Publisher: Association of Radiology and Oncology Year of publishing: 2005 Number of pages: str. 61-70 Numbering: Letn. 39, št. 1 Source: Ljubljana PID: 20.500.12556/DiRROS-18166  UDC: 616 ISSN on article: 1318-2099 COBISS.SI-ID: 19252953  Copyright: by Authors Note: BSDOCID113173; Publication date in DiRROS: 14.02.2024 Views: 131 Downloads: 32 Metadata:     Cite this work Plain text BibTeX EndNote XML EndNote/Refer RIS ABNT ACM Ref AMA APA Chicago 17th Author-Date Harvard IEEE ISO 690 MLA Vancouver : Copy citation

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Record is a part of a journal

Title:	Radiology and oncology
Shortened title:	Radiol. oncol.
Publisher:	Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:	1318-2099
COBISS.SI-ID:	32649472

Secondary language

Language:	Slovenian
Title:	Z dimetilhidrazinom inducirani tumorji debelega črevesa in danke pri podgani
Abstract:	Živalski modeli so pri raziskavah raka na debelem črevesju in danki nepogrešljivi, saj omogočajo raziskovanje in testiranje številnih dejavnikov, ki jih ni mogoče neposredno ugotavljati pri ljudeh. Edinega izmed živalskih modelov raka na debelem črevesju in danki predstavljajo z dimetilhidrazinom (DMH) inducirane podgane, ki razvijejo tumorje debelega črevesa in danke zelo podobne humanim. S člankom želimo predstaviti morfološke in genetske spremembetega modela, ki je veliko prispeval k današnjemu poznavanju etioloških in drugih dejavnikov, ki vplivajo na nastanek in razvoj raka. Danespa je nepogrešljiv pri raziskavah črevesnih karcinogenov in kemopreventivnih substanc.

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