| Naslov: | Detection of apoptotic cells in tumour paraffin sections |
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| Avtorji: | ID Pižem, Jože (Avtor)
ID Cör, Andrej (Avtor) |
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| Datoteke: |  PDF - Predstavitvena datoteka, prenos (170,01 KB)
MD5: F177126867596850636A2EC604332548
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.04 - Strokovni članek |
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| Organizacija: |  OI - Onkološki inštitut Ljubljana
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| Povzetek: | Apoptosis is a distinct form of cell death characterised by specific morphological features and regulated by complex molecular mechanisms. Its deregulation is fundamental for tumour growth and progression and, moreover, anticancer therapies suppress tumour growth mainly by induction of apoptosis. Since the extent of apoptosis in a tumour may have prognostic as well as therapeutic implications, much effort has been invested in developing specificmethods that can be routinely used to detect apoptotic cells in archival formalin fixed paraffin-embedded tissue. Complex molecular pathways are involved in the regulation of apoptosis. Pro-apoptotic signals trigger activation of caspases that specifically cleave target proteins. Cleavage of proteins (caspase substrates) is responsible for morphological changes of apoptotic cells and DNA fragmentation. In the last decade, detection of apoptotic cells in formalin fixed tumour tissue sections has been based mainlyon morphology and characteristic DNA fragmentation. Recently, specific antibodies to activated caspases and cleaved target proteins (including cytokeratin 18, actin and PARP) have been produced that enable accurate detection of apoptosis in paraffin sections. |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Datum objave: | 01.01.2003 |
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| Založnik: | Association of Radiology and Oncology |
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| Leto izida: | 2003 |
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| Št. strani: | str. 225-232 |
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| Številčenje: | Letn. 37, št. 4 |
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| Izvor: | Ljubljana |
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| PID: | 20.500.12556/DiRROS-18112-a385887e-0fe2-397e-2343-ac8850b3ce23  |
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| UDK: | 616-006 |
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| ISSN pri članku: | 1318-2099 |
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| COBISS.SI-ID: | 17382873 |
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| Avtorske pravice: | by Authors |
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| Opomba: | BSDOCID104069;
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| Datum objave v DiRROS: | 06.02.2024 |
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| Število ogledov: | 546 |
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| Število prenosov: | 110 |
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| Metapodatki: |    |
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