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Title:Treatment patterns, testing practices, and outcomes in the pre-FLAURA era for patients with EGFR mutation-positive advanced NSCLC : a retrospective chart review (REFLECT)
Authors:ID Addeo, Alfredo (Author)
ID Hochmair, Maximilian J (Author)
ID Janžič, Urška, Klinika Golnik (Author)
ID Dudnik, Elizabeth (Author)
ID Charpidou, Andriani (Author)
ID Płużański, Adam (Author)
ID Ciuleanu, Tudor (Author)
ID Shterev Donev, Ivan (Author)
ID Elbaz, Judith (Author)
ID Aarøe, Jørgen (Author)
ID Ott, René (Author)
ID Peled, Nir (Author)
Files:URL URL - Source URL, visit https://journals.sagepub.com/doi/pdf/10.1177/17588359211059874
 
Language:English
Typology:1.01 - Original Scientific Article
Organization:Logo UKPBAG - University Clinic of Respiratory and Allergic Diseases Golnik
Abstract:Background. Immunotherapy with immune checkpoint inhibitors (ICIs) recently became the standard treatment for patients with advanced non-small cell lung cancer (NSCLC). Here, we present the first results of a real-world observational study on the effectiveness of ICI monotherapy in patients with advanced NSCLC treated at a single academic center in a Central and Eastern European (CEE) country. Materials and methods. Overall, 66 consecutive patients with advanced NSCLC treated with ICIs in everyday clinical practice, either with first-line pembrolizumab (26 patients) or second-line atezolizumab, nivolumab, or pembrolizumab (40 patients), from August 2015 to November 2018, were included. All data were retrieved from a hospital lung cancer registry, in which the data is collected prospectively. Results. Included patients had a median age of 64 years, most were male (55%), 6% were in performance status >/=2, and 18% had controlled central nervous system metastases at baseline. In first-line, the median progression-free survival (mPFS) was 9.3 months, while the median overall survival (mOS) was not reached. The 1-year overall survival (OS) was 62%. In second-line, the mPFS and mOS were 3.5 months and 9.9 months, respectively, with a 1-year OS of 35%. In the overall population, adverse events of any grade were recorded in 79% of patients and of severe grade (3-4) in 12% of patients. Conclusion. The first real-world outcomes of NSCLC immunotherapy from a CEE country suggest comparable effectiveness to those observed in clinical trials and other real-world series, mainly coming from North America and Western European countries. Further data to inform on the real-world effectiveness of immunotherapy worldwide are needed.
Keywords:non-small cell lung carcinoma, immunotherapy, advanced non-small cell lung cancer, real-world data, Europe, Central Europe, Eastern Europe
Geographic coverage:Europe; Europe, Eastern; Evropa; Vzhodna Evropa;
Publication status:Published
Publication version:Version of Record
Place of publishing:Velika Britanija
Publisher:Sage
Year of publishing:2021
Number of pages:str. 1-11
Numbering:Vol. 13
PID:20.500.12556/DiRROS-14664 New window
UDC:616-006
ISSN on article:1758-8359
DOI:10.1177/17588359211059874 New window
COBISS.SI-ID:89318403 New window
Copyright:© The Author(s), 2021
Note:Nasl. z nasl. zaslona; Soavtorica iz Slovenije: Urška Janžič; Opis vira z dne 14. 12. 2021;
Publication date in DiRROS:15.12.2021
Views:1409
Downloads:677
Metadata:XML DC-XML DC-RDF
:
ADDEO, Alfredo, HOCHMAIR, Maximilian J, JANŽIČ, Urška, DUDNIK, Elizabeth, CHARPIDOU, Andriani, PŁUŻAŃSKI, Adam, CIULEANU, Tudor, SHTEREV DONEV, Ivan, ELBAZ, Judith, AARØE, Jørgen, OTT, René and PELED, Nir, 2021, Treatment patterns, testing practices, and outcomes in the pre-FLAURA era for patients with EGFR mutation-positive advanced NSCLC : a retrospective chart review (REFLECT). Therapeutic advances in medical oncology [online]. 2021. Vol. 13, p. 1–11. [Accessed 25 March 2025]. DOI 10.1177/17588359211059874. Retrieved from: https://journals.sagepub.com/doi/pdf/10.1177/17588359211059874
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Record is a part of a journal

Title:Therapeutic advances in medical oncology
Shortened title:Ther. adv. med. oncol.
Publisher:SAGE Publications
ISSN:1758-8359
COBISS.SI-ID:519822105 New window

Licences

License:CC BY-NC 4.0, Creative Commons Attribution-NonCommercial 4.0 International
Link:http://creativecommons.org/licenses/by-nc/4.0/
Description:A creative commons license that bans commercial use, but the users don’t have to license their derivative works on the same terms.
Licensing start date:27.10.2021

Secondary language

Language:Undetermined
Keywords:nedrobnocelični karcinom pljuč, imunoterapija, napredovali nedrobnocelinčni karcinom pljuč, podatki iz resničnega življenja, Evropa, srednja Evropa, Vzhodna Evropa


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