| Naslov: | Morphologic and molecular classification of lung neuroendocrine neoplasms |
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| Avtorji: | ID Metovic, Jasna (Avtor)
ID Barella, Marco (Avtor)
ID Bianchi, Fabrizio (Avtor)
ID Hofman, Paul (Avtor)
ID Hofman, Veronique (Avtor)
ID Remmelink, Myriam (Avtor)
ID Kern, Izidor, Klinika Golnik (Avtor)
ID Carvalho, Lina (Avtor)
ID Pattini, Linda (Avtor)
ID Sonzogni, Angelica (Avtor) |
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| Datoteke: |  PDF - Predstavitvena datoteka, prenos (2,60 MB)
MD5: E31912859DC921E02096FD7F44CCF722
 URL - Izvorni URL, za dostop obiščite https://link.springer.com/content/pdf/10.1007/s00428-020-03015-z.pdf
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: |  UKPBAG - Univerzitetna klinika za pljučne bolezni in alergijo Golnik
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| Povzetek: | Neuroendocrine neoplasms (NENs) of the lung encompass neuroendocrine tumors (NETs) composed of typical (TC) and atypical (AC) carcinoids and full-fledged carcinomas (NECs) inclusive of large cell neuroendocrine carcinoma (LCNEC) and small cell carcinoma (SCLC). NETs and NECs are thought to represent distinct and separate lesions with neither molecular overlap nor common developmental continuum. Two perspectives were addressed regarding the morphologic and molecular classification of lung NENs: (i) a supervised approach by browsing the traditional classification, the relevant gene alterations, and their clinical implications; and (ii) an unsupervised approach, by reappraising neoplasms according to risk factors and natural history of disease to construct an interpretation model relied on biological data. We herein emphasize lights and shadows of the current classification of lung NENs and provide an alternative outlook on these tumors focused on what we currently know about the biological determinants and the natural history of disease. |
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| Ključne besede: | neuroendocrine tumors, lung neoplasms, carcinoma, lung tumors, morphologic classification, molecular classification |
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| Status publikacije: | V tisku |
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| Verzija publikacije: | Recenzirani rokopis |
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| Kraj izida: | Nemčija |
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| Založnik: | Springer Nature |
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| Leto izida: | 2021 |
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| Št. strani: | str. [1-15] |
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| Številčenje: | Vol. 478, iss. |
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| PID: | 20.500.12556/DiRROS-13700  |
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| UDK: | 616-006 |
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| ISSN pri članku: | 1432-2307 |
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| DOI: | 10.1007/s00428-020-03015-z |
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| COBISS.SI-ID: | 49608195 |
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| Avtorske pravice: | (c) The Author(s) 2021 |
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| Opomba: | Nasl. z nasl. zaslona;
Soavtor iz Slovenije: Izidor Kern;
Opis vira z dne 1. 2. 2021;
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| Datum objave v DiRROS: | 02.02.2021 |
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| Število ogledov: | 1540 |
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| Število prenosov: | 998 |
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| Metapodatki: |    |
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