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Title:Morphologic and molecular classification of lung neuroendocrine neoplasms
Authors:ID Metovic, Jasna (Author)
ID Barella, Marco (Author)
ID Bianchi, Fabrizio (Author)
ID Hofman, Paul (Author)
ID Hofman, Veronique (Author)
ID Remmelink, Myriam (Author)
ID Kern, Izidor, Klinika Golnik (Author)
ID Carvalho, Lina (Author)
ID Pattini, Linda (Author)
ID Sonzogni, Angelica (Author)
Files:.pdf PDF - Presentation file, download (2,60 MB)
MD5: E31912859DC921E02096FD7F44CCF722
 
URL URL - Source URL, visit https://link.springer.com/content/pdf/10.1007/s00428-020-03015-z.pdf
 
Language:English
Typology:1.01 - Original Scientific Article
Organization:Logo UKPBAG - University Clinic of Respiratory and Allergic Diseases Golnik
Abstract:Neuroendocrine neoplasms (NENs) of the lung encompass neuroendocrine tumors (NETs) composed of typical (TC) and atypical (AC) carcinoids and full-fledged carcinomas (NECs) inclusive of large cell neuroendocrine carcinoma (LCNEC) and small cell carcinoma (SCLC). NETs and NECs are thought to represent distinct and separate lesions with neither molecular overlap nor common developmental continuum. Two perspectives were addressed regarding the morphologic and molecular classification of lung NENs: (i) a supervised approach by browsing the traditional classification, the relevant gene alterations, and their clinical implications; and (ii) an unsupervised approach, by reappraising neoplasms according to risk factors and natural history of disease to construct an interpretation model relied on biological data. We herein emphasize lights and shadows of the current classification of lung NENs and provide an alternative outlook on these tumors focused on what we currently know about the biological determinants and the natural history of disease.
Keywords:neuroendocrine tumors, lung neoplasms, carcinoma, lung tumors, morphologic classification, molecular classification
Publication status:In print
Publication version:Author Accepted Manuscript
Place of publishing:Nemčija
Publisher:Springer Nature
Year of publishing:2021
Number of pages:str. [1-15]
Numbering:Vol. 478, iss.
PID:20.500.12556/DiRROS-13700 New window
UDC:616-006
ISSN on article:1432-2307
DOI:10.1007/s00428-020-03015-z New window
COBISS.SI-ID:49608195 New window
Copyright:(c) The Author(s) 2021
Note:Nasl. z nasl. zaslona; Soavtor iz Slovenije: Izidor Kern; Opis vira z dne 1. 2. 2021;
Publication date in DiRROS:02.02.2021
Views:1756
Downloads:1112
Metadata:XML DC-XML DC-RDF
:
METOVIC, Jasna, BARELLA, Marco, BIANCHI, Fabrizio, HOFMAN, Paul, HOFMAN, Veronique, REMMELINK, Myriam, KERN, Izidor, CARVALHO, Lina, PATTINI, Linda and SONZOGNI, Angelica, 2021, Morphologic and molecular classification of lung neuroendocrine neoplasms. Virchows archiv [online]. 2021. Vol. 478, p. 1–15. [Accessed 22 April 2025]. DOI 10.1007/s00428-020-03015-z. Retrieved from: https://dirros.openscience.si/IzpisGradiva.php?lang=eng&id=13700
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Record is a part of a journal

Title:Virchows archiv
Publisher:Springer
ISSN:1432-2307
COBISS.SI-ID:2517524 New window

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:21.01.2021

Secondary language

Language:Undetermined
Keywords:nevroendokrini tumorji, pljučne novotvorbe, karcinom, pljučni tumorji, morfološka klasifikacija, molekularna klasifikacija


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