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Title:Emphysema and extrapulmonary tissue loss in COPD: a multi-organ loss of tissue phenotype
Authors:ID Celli, Bartolome R. (Author)
ID Locantore, Nicholas (Author)
ID Tal-Singer, Ruth (Author)
ID Riley, John (Author)
ID Vestbo, Jørgen (Author)
ID Yates, Julie C. (Author)
ID Miller, Bruce E. (Author)
ID Silverman, Edwin K (Author)
ID Owen, Caroline A. (Author)
ID Divo, Miguel (Author)
ID Košnik, Mitja (Associated name)
ID Košnik, Mitja (Research coworker)
Files:URL URL - Source URL, visit http://erj.ersjournals.com/content/51/2/1702146
 
Language:English
Typology:1.01 - Original Scientific Article
Organization:Logo UKPBAG - University Clinic of Respiratory and Allergic Diseases Golnik
Abstract:We tested whether emphysema progression accompanies enhanced tissue loss in other body compartments in 1817 patients from the ECLIPSE chronic obstructive pulmonary disease (COPD) cohort. Clinical and selected systemic biomarker measurements were compared in subjects grouped by quantitative tomography scan emphysema quartiles using the percentage of low attenuation area (LAA%). Lowest and highest quartile patients had amino-acid metabolomic profiles. We related LAA% to 3 years decline in lung function (forced expiratory volume in 1 s (FEV1)), body mass index (BMI), fat-free mass index (FFMI) and exacerbations, hospitalisations and mortality rates. Participants with more baseline emphysema had lower FEV1, BMI and FFMI, worse functional capacity, and less cardiovascular disease but more osteoporosis. Systemic C-reactive protein and interleukin-6 levels were similar among groups, but club cell protein 16 was higher and interleukin-8, surfactant protein D and soluble receptor for advanced glycation end product were lower with more emphysema. Metabolomics differed between extreme emphysema quartiles. Patients with more emphysema had accelerated FEV1, BMI and FFMI decline and more exacerbations, hospitalisations and mortality. COPD patients with more emphysema undergo excessive loss of pulmonary and extrapulmonary tissue, which is probably related to abnormal tissue maintenance. Because of worse clinical outcomes, we propose this subgroup be named the multi-organ loss of tissue (MOLT) COPD phenotype.
Keywords:COPD, chronic obstructive pulmonary disease, emphysema
Publication status:Published
Publication version:Version of Record
Place of publishing:Velika Britanija
Publisher:European Respiratory Society
Year of publishing:2018
Number of pages:str. 1-10
Numbering:Vol. 51, iss. 2
PID:20.500.12556/DiRROS-12903 New window
UDC:616.2
ISSN on article:1399-3003
DOI:10.1183/13993003.02146-2017 New window
COBISS.SI-ID:2048254321 New window
Copyright:©ERS 2018
Note:Soavtorji: Nicholas Locantore, Ruth Tal-Singer, John Riley, Bruce Miller, Jørgen Vestbo, Julie C. Yates, Edwin K. Silverman, Caroline A. Owen, Miguel Divo, Victor Pinto-Plata, Emiel F. M. Wouters, Rosa Faner and Alvar Agusti, on behalf of the ECLIPSE Study Investigators; Nasl. z nasl. zaslona; Opis vira z dne 7. 3. 2018;
Publication date in DiRROS:14.12.2020
Views:1885
Downloads:552
Metadata:XML DC-XML DC-RDF
:
CELLI, Bartolome R., LOCANTORE, Nicholas, TAL-SINGER, Ruth, RILEY, John, VESTBO, Jørgen, YATES, Julie C., MILLER, Bruce E., SILVERMAN, Edwin K, OWEN, Caroline A. and DIVO, Miguel, 2018, Emphysema and extrapulmonary tissue loss in COPD: a multi-organ loss of tissue phenotype. European respiratory journal [online]. 2018. Vol. 51, no. 2, p. 1–10. [Accessed 3 April 2025]. DOI 10.1183/13993003.02146-2017. Retrieved from: http://erj.ersjournals.com/content/51/2/1702146
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Record is a part of a journal

Title:European respiratory journal
Shortened title:Eur. respir. j.
Publisher:European Respiratory Society
ISSN:1399-3003
COBISS.SI-ID:521261849 New window

Secondary language

Language:Undetermined
Keywords:KOPB, kronična obstruktivna pljučna bolezen, emfizem


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