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Naslov:The clinical relevance of oliguria in the critically ill patient : analysis of a large observational database
Avtorji:Vincent, Jean Louis (Avtor)
Ferguson, Andrew (Avtor)
Pickkers, Peter (Avtor)
Jakob, Stephan M. (Avtor)
Jaschinski, Ulrich (Avtor)
Almekhlafi, Ghaleb A. (Avtor)
Leone, Marc (Avtor)
Mokhtari, Majid (Avtor)
Fontes, Luis E. (Avtor)
Bauer, Philippe R. (Avtor)
Sakr, Yasser (Avtor)
Tomič, Viktorija (Z enoto povezano ime)
Jezik:Angleški jezik
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:Logo UKPBAG - Univerzitetna klinika za pljučne bolezni in alergijo Golnik
Povzetek:Background: Urine output is widely used as one of the criteria for the diagnosis and staging of acute renal failure, but few studies have specifically assessed the role of oliguria as a marker of acute renal failure or outcomes in general intensive care unit (ICU) patients. Using a large multinational database, we therefore evaluated the occurrence of oliguria (defined as a urine output < 0.5 ml/kg/h) in acutely ill patients and its association with the need for renal replacement therapy (RRT) and outcome. Methods: International observational study. All adult (> 16 years) patients in the ICON audit who had a urine output measurement on the day of admission were included. To investigate the association between oliguria and mortality, we used a multilevel analysis. Results: Of the 8292 patients included, 2050 (24.7%) were oliguric during the first 24 h of admission. Patients with oliguria on admission who had at least one additional 24-h urine output recorded during their ICU stay (n = 1349) were divided into three groups: transient-oliguria resolved within 48 h after the admission day (n = 390 [28.9%]), prolonged-oliguria resolved > 48 h after the admission day (n = 141 [10.5%]), and permanent-oliguria persisting for the whole ICU stay or again present at the end of the ICU stay (n = 818 [60.6%]). ICU and hospital mortality rates were higher in patients with oliguria than in those without, except for patients with transient oliguria who had significantly lower mortality rates than non-oliguric patients. In multilevel analysis, the need for RRT was associated with a significantly higher risk of death (OR = 1.51 [95% CI 1.19%1.91], p = 0.001), but the presence of oliguria on admission was not (OR = 1.14 [95% CI 0.97%1.34], p = 0.103). Conclusions: Oliguria is common in ICU patients and may have a relatively benign nature if only transient. The duration of oliguria and need for RRT are associated with worse outcome.
Ključne besede:critical care, critical illness, urine, oliguria, kidney, renal insufficiency, kidney diseases, acute kidney failure, mortality, urine output, renal replacement therapy
Leto izida:2020
Založnik:Springer Nature
Izvor:Velika Britanija
UDK:616.1/.4
ISSN pri članku:1466-609X
OceCobissID:1137983 Povezava se odpre v novem oknu
COBISS_ID:37575171 Povezava se odpre v novem oknu
DOI:10.1186/s13054-020-02858-x Povezava se odpre v novem oknu
Opombe:Nasl. z nasl. zaslona; Opis vira z dne 16. 11. 2020; Sodelavci pri raziskavi iz Slovenije: Gorazd Voga, Erik Rupnik, Lucka Kosec, Milena Kerin Povšic, Irena Osojnik, Viktorija Tomic, Andreja Sinkovic; Article no. 171;
Število ogledov:20
Število prenosov:55
Datoteke:URL URL - Predstavitvena datoteka, za dostop obiščite https://ccforum.biomedcentral.com/track/pdf/10.1186/s13054-020-02858-x.pdf
 
Nadgradivo:Crit. care
BMC
 
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
Avtorske pravice:© The Author(s). 2020
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Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:23.04.2020

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