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Title:The use of drug provocation testing in the investigation of suspected immediate perioperative allergic reactions : current status
Authors:ID Garvey, Lene Heise (Author)
ID Ebo, Didier G. (Author)
ID Krøigaard, Mogens (Author)
ID Savic, Sinisa (Author)
ID Clarke, Russel C. (Author)
ID Cooke, Peter J. (Author)
ID Dewachter, Pascale (Author)
ID Garcez, Tomaz (Author)
ID Guttormsen, Anne Berit (Author)
ID Hopkins, Philip M. (Author)
ID Kopač, Peter, Klinika Golnik, Medicinska fakulteta UL (Author)
Files:URL URL - Source URL, visit https://bjanaesthesia.org/article/S0007-0912(19)30220-X/fulltext
 
Language:English
Typology:1.02 - Review Article
Organization:Logo UKPBAG - University Clinic of Respiratory and Allergic Diseases Golnik
Abstract:Suspected perioperative allergic reactions are often severe. To avoid potentially life-threatening re-exposure to the culprit drug, establishing a firm diagnosis and identifying the culprit is crucial. Drug provocation tests are considered the gold standard in drug allergy investigation but have not been recommended in the investigation of perioperative allergy, mainly because of the pharmacological effects of drugs such as induction agents and neuromuscular blocking agents. Some specialised centres have reported benefits of provocation testing in perioperative allergy investigation, but the literature on the subject is limited. Here we provide a status update on the use of drug provocation testing in perioperative allergy, including its use in specific drug groups. This review is based on a literature search and experiences of the authors comprising anaesthesiologists and allergists with experience in perioperative allergy investigation. In addition, 19 participating centres in the International Suspected Perioperative Allergic Reaction Group were surveyed on the use of provocation testing in perioperative allergy investigation. A response was received from 13 centres in eight European countries, New Zealand, and the USA. Also, 21 centres from the Australian and New Zealand Anaesthetic Allergy Group were surveyed. Two centres performed provocation routinely and seven centres performed no provocations at all. Nearly half of the centres reported performing provocations with induction agents and neuromuscular blocking agents. Drug provocation testing is being used in perioperative allergy investigation in specialised centres, but collaborations between relevant specialties and multicentre studies are necessary to determine indications and establish common testing protocols.
Keywords:allergy and immunology, drug hypersensitivity, anesthesia, drug-related side effects and adverse reactions, anaphylaxis, perioperative period, allergic reactions, hypersensitivity reaction, perioperative anaphylaxis, allergy testing, challenge testing, drug provocation test
Publication status:Published
Publication version:Version of Record
Place of publishing:Velika Britanija
Publisher:Elsevier
Year of publishing:2019
Number of pages:str. e126-e134
Numbering:Vol. 123, iss. 1
PID:20.500.12556/DiRROS-12543 New window
UDC:616-097
ISSN on article:1471-6771
DOI:10.1016/j.bja.2019.03.018 New window
COBISS.SI-ID:2048510321 New window
Copyright:© 2019 British Journal of Anaesthesia
Note:Soavtor iz Slovenije: Peter Kopac; Nasl. z nasl. zaslona; Opis vira z dne 5. 6. 2019;
Publication date in DiRROS:09.10.2020
Views:1987
Downloads:789
Metadata:XML DC-XML DC-RDF
:
GARVEY, Lene Heise, EBO, Didier G., KRØIGAARD, Mogens, SAVIC, Sinisa, CLARKE, Russel C., COOKE, Peter J., DEWACHTER, Pascale, GARCEZ, Tomaz, GUTTORMSEN, Anne Berit, HOPKINS, Philip M. and KOPAČ, Peter, 2019, The use of drug provocation testing in the investigation of suspected immediate perioperative allergic reactions : current status. British journal of anaesthesia [online]. 2019. Vol. 123, no. 1, p. e126–e134. [Accessed 7 April 2025]. DOI 10.1016/j.bja.2019.03.018. Retrieved from: https://bjanaesthesia.org/article/S0007-0912(19)30220-X/fulltext
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Record is a part of a journal

Title:British journal of anaesthesia
Shortened title:Br. j. anaesth.
Publisher:Oxford University Press.
ISSN:1471-6771
COBISS.SI-ID:515369241 New window

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License:Other
Description:Elsevier user licence
Licensing start date:23.04.2019

Secondary language

Language:Undetermined
Keywords:alergija in imunologija, preobčutljivost za zdravila, anestezija, stranski in škodljivi učinki zdravil, anafilaksija, perioperativno obdobje, alergijske reakcije, preobčutljivostna reakcija, perioperativna anafilaksija, alergijsko testiranje, provokacijsko testiranje, provokacijski testiranje z zdravili


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