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Title:Pulmonary pathology and COVID-19 : lessons from autopsy : the experience of European pulmonary pathologists
Authors:ID Calabrese, Fiorella (Author)
ID Pezzuto, Federica (Author)
ID Fortarezza, Francesco (Author)
ID Hofman, Paul (Author)
ID Kern, Izidor, Klinika Golnik (Author)
ID Panizo, Angel (Author)
ID Thüsen, Jan von der (Author)
ID Timofeev, Sergei (Author)
ID Gorkiewicz, Gregor (Author)
ID Lunardi, Francesca (Author)
Files:.pdf PDF - Presentation file, download (1,55 MB)
MD5: 256373B8D6A083C6B61D8B373489EFD4
 
URL URL - Source URL, visit https://link.springer.com/content/pdf/10.1007/s00428-020-02886-6.pdf
 
Language:English
Typology:1.01 - Original Scientific Article
Organization:Logo UKPBAG - University Clinic of Respiratory and Allergic Diseases Golnik
Abstract:Since its initial recognition in December 2019, Coronavirus disease 19 (COVID-19) has quickly spread to a pandemic infectious disease. The causative agent has been recognized as a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), primarily affecting the respiratory tract. To date, no vaccines are available nor any specific treatment. To limit the number of infections, strict directives have been issued by governments that have been translated into equally rigorous guidelines notably for post-mortem examinations by international and national scientific societies. The recommendations for biosafety control required during specimen collection and handling have strongly limited the practice of autopsies of the COVID-19 patients to a few adequate laboratories. A full pathological examination has always been considered an important tool to better understand the pathophysiology of diseases, especially when the knowledge of an emerging disorder is limited and the impact on the healthcare system is significant. The first evidence of diffuse alveolar damage in the context of an acute respiratory distress syndrome has now been joined by the latest findings that report a more complex scenario in COVID-19, including a vascular involvement and a wide spectrum of associated pathologies. Ancillary tools such as electron microscopy and molecular biology used on autoptic tissue samples from autopsy are also significantly contributing to confirm and/or identify new aspects useful for a deeper knowledge of the pathogenetic mechanisms. This article will review and summarize the pathological findings described in COVID-19 until now, chiefly focusing on the respiratory tract, highlighting the importance of autopsy towards a better knowledge of this disease.
Keywords:COVID-19, SARS-CoV-2, autopsy, lung, pandemic
Publication status:In print
Publication version:Author Accepted Manuscript
Place of publishing:Nemčija
Publisher:Springer Nature
Year of publishing:2020
Number of pages:str. [1-14]
Numbering:Vol. 477, iss.
PID:20.500.12556/DiRROS-12301 New window
UDC:616.2
ISSN on article:1432-2307
DOI:10.1007/s00428-020-02886-6 New window
COBISS.SI-ID:23930627 New window
Copyright:The Author(s) 2020
Note:Nasl. z nasl. zaslona; Soavtor iz Slovenije: Izidor Kern; Opis vira z dne 29. 7. 2020;
Publication date in DiRROS:31.07.2020
Views:14590
Downloads:1424
Metadata:XML DC-XML DC-RDF
:
CALABRESE, Fiorella, PEZZUTO, Federica, FORTAREZZA, Francesco, HOFMAN, Paul, KERN, Izidor, PANIZO, Angel, THÜSEN, Jan von der, TIMOFEEV, Sergei, GORKIEWICZ, Gregor and LUNARDI, Francesca, 2020, Pulmonary pathology and COVID-19 : lessons from autopsy : the experience of European pulmonary pathologists. Virchows archiv [online]. 2020. Vol. 477, p. 1–14. [Accessed 17 March 2025]. DOI 10.1007/s00428-020-02886-6. Retrieved from: https://dirros.openscience.si/IzpisGradiva.php?lang=eng&id=12301
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Record is a part of a journal

Title:Virchows archiv
Publisher:Springer
ISSN:1432-2307
COBISS.SI-ID:2517524 New window

Licences

License:CC BY-NC 4.0, Creative Commons Attribution-NonCommercial 4.0 International
Link:http://creativecommons.org/licenses/by-nc/4.0/
Description:A creative commons license that bans commercial use, but the users don’t have to license their derivative works on the same terms.
Licensing start date:28.06.2020

Secondary language

Language:Undetermined
Keywords:covid-19, SARS-CoV-2, obdukcija, pljuča, pandemija


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