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Title:Comparative analysis of prognostic histopathologic parameters in subtypes of epithelioid pleural mesothelioma
Authors:ID Bilecz, Agnes (Author)
ID Stockhammer, Paul (Author)
ID Theegarten, Dirk (Author)
ID Kern, Izidor, Klinika Golnik (Author)
ID Jakopović, Marko (Author)
ID Samaržija, Miroslav (Author)
ID Klikovits, Thomas (Author)
ID Hoda, Mir Alireza (Author)
ID Dome, Balazs (Author)
ID Oberndorfer, Felicitas (Author)
Files:.pdf PDF - Presentation file, download (1,66 MB)
MD5: B44113E9F82E5BB2ECFD0D50988304DD
 
.zip ZIP - Supplement, download (2,16 MB)
MD5: 11E8F900D070B60826563DC49FD2C537
 
URL URL - Source URL, visit https://onlinelibrary.wiley.com/doi/epdf/10.1111/his.14105
 
Language:English
Typology:1.01 - Original Scientific Article
Organization:Logo UKPBAG - University Clinic of Respiratory and Allergic Diseases Golnik
Abstract:Malignant pleural mesothelioma (MPM) is a rare malignancy with a dismal prognosis. While the epithelioid type is associated with a more favourable outcome, additional factors are needed to further stratify prognosis and to identify patients who can benefit from multimodal treatment. As epithelioid MPM shows remarkable morphological variability, the prognostic role of the five defined morphologies, the impact of the nuclear grading system and the mitosis-necrosis score were investigated in this study. Methods and results: Tumour specimens of 192 patients with epithelioid MPM from five European centres were histologically subtype d. Nuclear grading and mitosis–necrosi s score were determined and correlated with clinicopathological parameters and overall survival (OS). Digital slides of 55 independent cases from The Cancer Genome Atlas (TCGA) database were evaluated for external validation. Histological subtypes were collapsed into three groups based on their overlapping survival curves. The tubulopapillary/microcystic group had a significantly longer OS than the solid/trabecular group (732 days versus 397 days, P = 0.0013). Pleomorphic tumours had the shortest OS (173 days). The solid/trabecular variants showed a significant association with high nuclear grade and mitosis – necrosis score. The mitosis–necrosis score was a robust and independent prognostic factor in our patient cohort. The prognos- tic significance of all three parameters was externally validated in the TCGA cohort. Patients with tubulopapillary or microcystic tumours showed a greater improvement in OS after receiving multimodal therapy than those with solid or trabecular tumours. Conclusions: Histological subtypes of epithelioid MPM have a prognostic impact, and might help to select patients for intensive multimodal treatment approaches.
Keywords:epithelioid malignant pleural mesothelioma, histological subtypes
Publication status:Published
Publication version:Version of Record
Place of publishing:ZDA
Publisher:John Wiley & Sons Ltd.
Year of publishing:2020
Number of pages:str. 55-66
Numbering:Vol. 77, iss. 1
PID:20.500.12556/DiRROS-12164 New window
UDC:616-006
ISSN on article:1365-2559
DOI:10.1111/his.14105 New window
COBISS.SI-ID:2048642929 New window
Copyright:© 2020 The Authors
Note:Nasl. z nasl. zaslona; Soavtor iz Slovenije: Izidor Kern; Opis vira z dne 16. 3. 2020;
Publication date in DiRROS:08.07.2020
Views:2294
Downloads:1476
Metadata:XML DC-XML DC-RDF
:
BILECZ, Agnes, STOCKHAMMER, Paul, THEEGARTEN, Dirk, KERN, Izidor, JAKOPOVIĆ, Marko, SAMARŽIJA, Miroslav, KLIKOVITS, Thomas, HODA, Mir Alireza, DOME, Balazs and OBERNDORFER, Felicitas, 2020, Comparative analysis of prognostic histopathologic parameters in subtypes of epithelioid pleural mesothelioma. Histopathology [online]. 2020. Vol. 77, no. 1, p. 55–66. [Accessed 19 March 2025]. DOI 10.1111/his.14105. Retrieved from: https://dirros.openscience.si/IzpisGradiva.php?lang=eng&id=12164
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Record is a part of a journal

Title:Histopathology
Shortened title:Histopathology
Publisher:Wiley
ISSN:1365-2559
COBISS.SI-ID:515021081 New window

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:08.07.2020

Secondary language

Language:Undetermined
Keywords:epiteloidni maligni plevralni mezoteliom, histološki podtipi


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