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Povzetek: Before initiating treatment of advanced nonesmall-cell lung cancer with tyrosine kinase inhibitors (eg, erlotinib, gefitinib, osimertinib, and afatinib), which inhibit the catalytic activity of epidermal growth factor receptor (EGFR), clinical guidelines require determining the EGFR mutational status for activating (EGFR exons 18, 19, 20, or 21) and resistance (EGFR exon 20) mutations. The EGFR resistance mutation T790M should be monitored at cancer progression. The Idylla EGFR Mutation Assay, performed on the Idylla molecular diagnostics platform, is a fully automated (<2.5 hours turnaround time) sample-to-result molecular test to qualitatively detect 51 EGFR oncogene point mutations, deletions, or insertions. In a 15- center evaluation, Idylla results on 449 archived formalin-fixed, paraffin-embedded tissue sections, originating from nonesmall-cell lung cancer biopsies and resection specimens, were compared with data obtained earlier with routine reference methods, including next-generation sequencing, Sanger sequencing, pyrosequencing, mass spectrometry, and PCR-based assays. When results were discordant, a third method of analysis was performed, when possible, to confirm test results. After confirmation testing and excluding invalids/errors and discordant results by design, a concordance of 97.6% was obtained between Idylla and routine test results. Even with <10 mm2 of tissue area, a valid Idylla result was obtained in 98.9% of the cases. The Idylla EGFR Mutation Assay enables sensitive detection of most relevant EGFR mutations in concordance with current guidelines, with minimal molecular expertise or infrastructure.
Ključne besede: non-small cell lung carconima -- diagnosis -- genetics, ErbB receptors, sequence analysis, tyrosine kinase inhibitors, epidermal growth factor receptor
Objavljeno v DiRROS: 07.10.2020; Ogledov: 1395; Prenosov: 989
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Povzetek: Reported COVID-19 deaths in Germany are relatively low as compared to many European countries. Among the several explanations proposed, an early and large testing of the population was put forward. Most current debates on COVID-19 focus on the differences among countries, but little attention has been given to regional differences and diet. The low-death rate European countries (e.g. Austria, Baltic States, Czech Republic, Finland, Norway, Poland, Slovakia) have used different quarantine and/or confinement times and methods and none have performed as many early tests as Germany. Among other factors that may be significant are the dietary habits. It seems that some foods largely used in these countries may reduce angiotensin-converting enzyme activity or are anti-oxidants. Among the many possible areas of research, it might be important to understand diet and angiotensin-converting enzyme-2 (ACE2) levels in populations with different COVID-19 death rates since dietary interventions may be of great benefit.
Ključne besede: coronavirus, diet, angiotensin-converting enzyme, antioxidant, food
Objavljeno v DiRROS: 09.09.2020; Ogledov: 1540; Prenosov: 1196
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Ključne besede: basophil activation test, drug hypersensitivity, immunologic desensitization, paclitaxel
Objavljeno v DiRROS: 07.08.2020; Ogledov: 1677; Prenosov: 471
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Ključne besede: varstvo gozdov, monitoring, stanje gozdov, zdravstveno stanje krošenj, popis povzročiteljev poškodb, meteorološke meritve, osutost dreves, poročila, Slovenija
Objavljeno v DiRROS: 04.08.2020; Ogledov: 2312; Prenosov: 902
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Povzetek: Worldwide, mountain forests represent a significant factor in reducing rockfall risk over long periods of time on large potential disposition areas. While the economic value of technical protection measures against rockfall can be clearly determined and their benefits indicated, there is no general consensus on the quantification of the protective effect of forests. Experience shows that wherever there is forest, the implementation of technical measures to reduce risk of rockfall might often be dispensable or cheaper, and large deforestations (e.g. after windthrows, forest fires, clear-cuts) often show an increased incidence of rockfall events. This study focussed on how the protective effect of a forest against rockfall can be quantified on an alpine transregional scale. We therefore estimated the runout length, in terms of the angle of reach, of 700 individual rockfall trajectories from 39 release areas from Austria, Germany, Italy and Slovenia. All recorded rockfall events passed through forests which were classified either as coppice forests or, according to the CORINE classification of land cover, as mixed, coniferous or broadleaved dominated high forest stands. For each individual rockfall trajectory, we measured the forest structural parameters stem number, basal area, top height, ratio of shrub to high forest and share of coniferous trees. To quantify the protective effect of forests on rockfall, a hazard reduction factor is introduced, defined as the ratio between an expected angle of reach without forest and the back-calculated forest-influenced angles of reach. The results show that forests significantly reduce the runout length of rockfall. The highest reduction was observed for mixed high forest stands, while the lowest hazard reduction was observed for high forest stands dominated either by coniferous or broadleaved tree species. This implies that as soon as one tree species dominates, the risk reduction factor becomes lower. Coppice forests showed the lowest variability in hazard reduction. Hazard reduction due to forests increases, on average, by 7% for an increase in the stem number by 100 stems per hectare. The proposed concept allows a global view of the effectiveness of protective forests against rockfall processes and thus enable to value forest ecosystem services for future transregional assessments on a European level. Based on our results, general cost%benefit considerations of nature-based solutions against rockfall, such as protective forests as well as first-order evaluations of rockfall hazard reduction effects of silvicultural measures within the different forest types, can be supported.
Ključne besede: protection forests, rockfall, European Alps, rockfall hazard
Objavljeno v DiRROS: 13.07.2020; Ogledov: 1616; Prenosov: 954
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