1. CA19-9 serum levels predict micrometastases in patients with gastric cancerTomaž Jagrič, Stojan Potrč, Katarina Miš, Mojca Plankl, Tomaž Marš, 2016, original scientific article Abstract: Background. We explored the prognostic value of the up-regulated carbohydrate antigen (CA19-9) in node-negative patients with gastric cancer as a surrogate marker for micrometastases. Patients and methods. Micrometastases were determined using reverse transcription quantitative polymerase chain reaction (RT-qPCR) for a subgroup of 30 node-negative patients. This group was used to determine the cut-off for preoperative CA19-9 serum levels as a surrogate marker for micrometastases. Then 187 node-negative T1 to T4 patients were selected to validate the predictive value of this CA19-9 threshold. Results. Patients with micrometastases had significantly higher preoperative CA19-9 serum levels compared to patients without micrometastases (p = 0.046). CA19-9 serum levels were significantly correlated with tumour site, tumour diameter, and perineural invasion. Although not reaching significance, subgroup analysis showed better five-year survival rates for patients with CA19-9 serum levels below the threshold, compared to patients with CA19-9 serum levels above the cut-off. The cumulative survival for T2 to T4 node-negative patients was significantly better with CA19-9 serum levels below the cut-off (p = 0.04). Conclusions. Preoperative CA19-9 serum levels can be used to predict higher risk for haematogenous spread and micrometastases in node-negative patients. However, CA19-9 serum levels lack the necessary sensitivity and specificity to reliably predict micrometastases.
Keywords: gastric cancer, micrometastases, CA19-9, rak (medicina), želodec, metastaze, diagnostika, antigeni, tumorski označevalci
Published in DiRROS: 09.05.2024; Views: 19; Downloads: 7
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2. Optimal scan time for evaluation of parathyroid adenoma with [18F]-fluorocholine PET/CTSebastijan Rep, Luka Ležaič, Tomaž Kocjan, Marija Pfeifer, Mojca Jensterle Sever, Urban Simončič, Petra Tomše, Marko Hočevar, 2015, original scientific article Keywords: lesions representing enlarged parathyroid tissue, triple-phase, standardized uptake value, retention index, lesion contrast, rak (medicina), obščitnični adenomi, diagnostika
Published in DiRROS: 22.04.2024; Views: 190; Downloads: 242
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4. Položaj priseljencev na področju zdravja in zdravstvenega varstva v SlovenijiRomana Bešter, Mojca Medvešek, Janez Pirc, 2020, independent scientific component part or a chapter in a monograph Keywords: integracija priseljencev, priseljenci, zdravje, zdravstveno varstvo, Slovenija, integracijska politika
Published in DiRROS: 16.04.2024; Views: 84; Downloads: 25
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6. Razvoj integracijskih programov za priseljence v SlovenijiMojca Medvešek, Romana Bešter, Janez Pirc, 2020, independent scientific component part or a chapter in a monograph Keywords: integracija, integracijska politika, integracijski programi, državljani držav nečlanic Evropske unije, začetna integracija priseljencev, slovenski jezik, Slovenija
Published in DiRROS: 16.04.2024; Views: 93; Downloads: 31
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10. Mnenja večinskega prebivalstva Slovenije o priseljevanju, priseljencih in integracijiMojca Medvešek, Romana Bešter, Janez Pirc, 2022, scientific monograph Keywords: imigracija, javno mnenje, vladna politika, Slovenija, imigranti, integracija
Published in DiRROS: 16.04.2024; Views: 112; Downloads: 72
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