1. Exploring BPA alternatives : environmental levels and toxicity reviewOndrej Adamovsky, Ksenia J Groh, Anna Białk-Bielińska, Beate I. Escher, R. Beaudouin, Liadys Mora Lagares, K. E. Tollefsen, Alja Štern, Tina Eleršek, Marjan Vračko, Bojana Žegura, 2024, review article Abstract: Bisphenol A alternatives are manufactured as potentially less harmful substitutes of bisphenol A (BPA) that offer similar functionality. These alternatives are already in the market, entering the environment and thus raising ecological concerns. However, it can be expected that levels of BPA alternatives will dominate in the future, they are limited information on their environmental safety. The EU PARC project highlights BPA alternatives as priority chemicals and consolidates information on BPA alternatives, with a focus on environmental relevance and on the identification of the research gaps. The review highlighted aspects and future perspectives. In brief, an extension of environmental monitoring is crucial, extending it to cover BPA alternatives to track their levels and facilitate the timely implementation of mitigation measures. The biological activity has been studied for BPA alternatives, but in a non-systematic way and prioritized a limited number of chemicals. For several BPA alternatives, the data has already provided substantial evidence regarding their potential harm to the environment. We stress the importance of conducting more comprehensive assessments that go beyond the traditional reproductive studies and focus on overlooked relevant endpoints. Future research should also consider mixture effects, realistic environmental concentrations, and the long-term consequences on biota and ecosystems. Keywords: BPA alternatives, biological activity, in silico, invertebrates, vertebrates, toxicity Published in DiRROS: 03.06.2024; Views: 99; Downloads: 51 Full text (1,64 MB) This document has many files! More... |
2. Treatment-related cardiovascular toxicity in long-term survivors of testicular cancerJasenka Gugić Kevo, Lorna Zadravec-Zaletel, Irena Oblak, 2017, review article Abstract: Testicular cancer is the most common malignancy in young men. Considering increasing incidence, exceptionally high cure rate, as well as long life expectancy, assessment of long term toxicity in testicular cancer survivors is of great importance. In the last decades a major effort has been made in order to reduce toxicity of treatment, while maintaining its high effectiveness. Conclusions Actual knowledge on treatment toxicity is based on outdated treatment modalities. Hopefully, modern treatment modalities could reduce toxicity, but, there is no firm confirmation for that at the moment, as data dealing with late sequelae of modern treatment of testicular cancer are not available yet due to the short period of observation. The life-threatening cardiovascular toxicity in testicular cancer survivors is major complication of platinum-based chemotherapy, mediastinal radiotherapy and even subdiaphragmatic radiotherapy. Keywords: testicular cancer, cardiovascular toxicity, long-term survivors Published in DiRROS: 24.05.2024; Views: 129; Downloads: 94 Full text (484,07 KB) |
3. Immunotoxin - a new treatment option in patients with relapsed and refractory Hodgkin lymphomaBarbara Jezeršek Novaković, 2015, review article Abstract: Background. Even though Hodgkin lymphoma is a highly curable disease, some of the patients have either a refractory disease or experience a relapse following a successful primary therapy. Durable responses and remissions in patients with relapsed or refractory disease may be achieved in approximately one-half with salvage chemotherapy followed by high dose chemotherapy (HDT) and autologous hematopoietic cell rescue (SCT). On the other hand, patients who relapse after HDT and autologous SCT or those who have failed at least two prior multi-agent chemotherapy regimens and are not candidates for HDT have limited treatment options. Conclusions. A new treatment option in this population is an immunotoxin Brentuximab vedotin composed of a CD30 directed antibody linked to the antitubulin agent monomethyl auristatin E. It has demonstrated a substantial effectiveness and an acceptable toxicity. In the pivotal study, the overall response rate was 75% with 34% of complete remissions. The median durations of response were 20.5 and 6.7 months for those with complete remission and all responding patients, respectively. The median overall survival was 40.5 months (3-years overall survival 54%) and the median progression-free survival 9.3 months. The most common non-hematologic toxicities were peripheral sensory neuropathy, nausea, and fatigue while the most common severe side effects were neutropenia, thrombocytopenia, anemia, and peripheral sensory neuropathy. Keywords: immunotoxin, Hodgkin lymphoma, toxicity, new treatment option Published in DiRROS: 22.04.2024; Views: 433; Downloads: 393 Full text (520,10 KB) |
4. Results of postoperative radiochemotherapy of the patients with resectable gastroesophageal junction adenocarcinoma in SloveniaAna Jeromen, Irena Oblak, Franc Anderluh, Vaneja Velenik, Marija Skoblar Vidmar, Ivica Ratoša, 2012, original scientific article Keywords: gastroesophageal junction adenocarcinoma, postoperative radiochemotherapy, toxicity Published in DiRROS: 21.03.2024; Views: 179; Downloads: 55 Full text (419,66 KB) |
5. Degradation and Stabilization of Polymer MaterialsBranka Mušič, Andrijana Sever Škapin, 2023, other scientific articles Keywords: polymer-based materials, nano, micro, and macro composites, effects on (micro) organisms and toxicity, impact on the ecosystem, mechanisms and products of accelerated aging and degradation, physical, chemical, mechanical, thermal, and morphological, analysis, biodegradability, sustainability, life cycle, renewable and recycled resources and the circular economy Published in DiRROS: 21.12.2023; Views: 337; Downloads: 114 Full text (226,05 KB) This document has many files! More... |
6. Stability and toxicity of selected chlorinated benzophenone-type UV filters in watersRomina Žabar, Darko Dolenc, Polonca Trebše, Tatjana Tišler, Gorica Grbović, Jun Yao, Rensheng Zhuang, 2013, original scientific article Abstract: Stability and toxicity of selected chlorinated benzophenone-type UV filters in waters Keywords: UV filter, photostability, chlorination, toxicity, Vibrio fischeri Published in DiRROS: 16.03.2016; Views: 3927; Downloads: 521 Link to full text |