1. Pharmacogenomic markers of glucorticoid responses in the initial phase of remission induction therapy in childhood acute lymphoblastic leukemiaVladimir Gasic, Branka Zukic, Biljana Stanković, Dragana Janić, Lidija Dokmanovic, Jelena Lazic, Nada Krstovski, Vita Dolžan, Janez Jazbec, Sonja Pavlovič, Nikola Kotur, 2018, original scientific article Keywords: pharmacogenomics, childhood ALL, glucocorticoids, glucocorticoid receptor gene, glutathione S-transferase genes, multidrug resistance 1 gene
Published in DiRROS: 11.06.2024; Views: 43; Downloads: 14
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2. In silico selection approach to develop DNA aptamers for a stem-like cell subpopulation of non-small lung cancer adenocarcinoma cell line A549Mateja Vidic, Tina Šmuc, Nikolaja Janež, Michael Blank, Tomaž Accetto, Jan Mavri, Isis Nascimento, Arthur A. Nery, Henning Ulrich, Tamara Lah Turnšek, 2018, original scientific article Published in DiRROS: 11.06.2024; Views: 47; Downloads: 25
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3. Guanidine modification improves functions of natural RNA-targeting alkaloidsTamaki Endoh, Sagar Satpathi, Yutong Chen, Saki Matsumoto, Tatsuya Ohyama, Peter Podbevšek, Janez Plavec, Kazumitsu Onizuka, Fumi Nagatsugi, Naoki Sugimoto, 2024, original scientific article Published in DiRROS: 10.06.2024; Views: 39; Downloads: 14
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4. Poročilo državnega programa obvladovanja raka za leto 2023Sonja Tomšič, Janez Žgajnar, Katarina Plantosar, Amela Duratović Konjević, Katarina Torkar, Branko Zakotnik, 2024, published professional conference contribution Keywords: obvladovanje raka, državni program, onkologija
Published in DiRROS: 06.06.2024; Views: 53; Downloads: 24
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5. Protein G-quadruplex interactions and their effects on phase transitions and protein aggregationBikash Ranjan Sahoo, Vojč Kocman, Nathan Clark, Nikhil Myers, Xiexiong Deng, Ee L. Wong, Harry J. Yang, Anita Kotar, Bryan B. Guzman, Daniel Dominguez, Janez Plavec, James C. A. Bardwell, 2024, original scientific article Published in DiRROS: 03.06.2024; Views: 110; Downloads: 99
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6. Association between SLC19A1 gene polymorphism and high dose methotrexate toxicity in childhood acute lymphoblastic leukaemia and non Hodgkin malignant lymphoma : introducing a haplotype based approachBarbara Faganel Kotnik, Janez Jazbec, Petra Bohanec Grabar, Christina Rodriguez-Antona, Vita Dolžan, 2017, original scientific article Keywords: acute lymphoblastic leukaemia, genetic polymorphism, haplotype, methotrexate
Published in DiRROS: 31.05.2024; Views: 93; Downloads: 78
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7. In vitro and in vivo evaluation of electrochemotherapy with trans-platinum analogue trans-[PtCl2(3-Hmpy)2]Simona Kranjc Brezar, Maja Čemažar, Gregor Serša, Janez Ščančar, Sabina Grabner, 2017, original scientific article Abstract: Background. Cisplatin is used in cancer therapy, but its side effects and acquired resistance to cisplatin have led to the synthesis and evaluation of new platinum compounds. Recently, the synthesized platinum compound trans- [PtCl2(3-Hmpy)2] (3-Hmpy = 3-hydroxymethylpyridine) (compound 2) showed a considerable cytotoxic and antitumour effectiveness. To improve compound 2 cytotoxicity in vitro and antitumour effectiveness in vivo, electroporation was used as drug delivery approach to increase membrane permeability (electrochemotherapy). Materials and methods. In vitro, survival of sarcoma cells with different intrinsic sensitivity to cisplatin (TBLCl2 sensitive, TBLCl2Pt resistant and SA-1 moderately sensitive) was determined using a clonogenic assay after treatment with compound 2 or cisplatin electrochemotherapy. In vivo, the antitumour effectiveness of electrochemotherapy with compound 2 or cisplatin was evaluated using a tumour growth delay assay. In addition, platinum in the serum, tumours and platinum bound to the DNA in the cells were performed using inductively coupled plasma mass spectrometry. Results. In vitro, cell survival after treatment with compound 2 electrochemotherapy was significantly decreased in all tested sarcoma cells with different intrinsic sensitivity to cisplatin (TBLCl2 sensitive, TBLCl2Pt resistant and SA-1 moderately sensitive). However, this effect was less pronounced compared to cisplatin. Interestingly, the enhancement factor (5-fold) of compound 2 cytotoxicity was equal in cisplatin-sensitive TBLCl2 and cisplatin-resistant TBLCl2Pt cells. In vivo, the growth delay of subcutaneous tumours after treatment with compound 2 electrochemotherapy was lower compared to cisplatin. The highest antitumour effectiveness after cisplatin or compound 2 electrochemotherapy was obtained in TBLCl2 tumours, resulting in 67% and 11% of tumour cures, respectively. Compound 2 induced significantly smaller loss of animal body weight compared to cisplatin. Furthermore, platinum amounts in tumours after compound 2 or cisplatin electrochemotherapy were approximately 2-fold higher compared to the drug treatment only, and the same increase of platinum bound to DNA was observed. Conclusions. The obtained results in vitro and in vivo suggest compound 2 as a potential antitumour agent in electrochemotherapy.
Keywords: platinum analogue, cisplatin, elektroporation, electrochemotherapy, 3-Hmpy
Published in DiRROS: 31.05.2024; Views: 98; Downloads: 54
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8. Poročilo o izvedbi naloge javnega naročila: »Monitoring ogljika v gozdnih tleh, mokriščih in urbanih tleh« - MEJNIK 4 : končno poročiloAleksander Marinšek, Daniel Žlindra, Mitja Ferlan, Erika Kozamernik, Boštjan Mali, Peter Horvat, Eva Zagorac, Nastja Mesarec, Janez Bergant, Borut Vrščaj, Primož Simončič, 2023, final research report Keywords: monitoring, ogljik, gozdna tla, mokrišča, urbana tla
Published in DiRROS: 24.05.2024; Views: 143; Downloads: 144
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10. Gozdna tla in vegetacija eno leto po požaru na Goriškem KrasuValerija Babij, Lado Kutnar, Aleksander Marinšek, Janez Kermavnar, 2024, original scientific article Abstract: V letu 2023 − eno leto po obsežnem požaru na Goriškem Krasu, ki je divjal julija leta 2022 − smo na izbranih gozdnih vzorčnih ploskvah popisali zeliščno, grmovno in drevesno vegetacijo in analizirali tla do globine 10 cm. Ploskve smo izbrali na lokacijah stalnih vzorčnih ploskev ZGS z različno stopnjo poškodovan osti zaradi požara. Na izbranih ploskvah smo skupno popisali 260 vrst praprotnic in semenk. V drevesni plasti smo popisali trinajst vrst (enajst domorodnih in dve tujerodni), v grmovni plasti trideset, v zeliščni pa 255. V drevesni plasti so bili najpogostejši mali jesen, črni gaber in črni bor, v grmovni mali jesen, navadni ruj in robide. V zeliščni plasti smo med drugimi popisali tudi devetnajst drevesnih vrst, ki so pomembna zasnova pri naravni obnovi požganega gozda na Krasu; najpogostejša sta bila črni gaber in rešeljika. Gradient poškodovanosti po požaru se jasno kaže v večini vegetacijskih in talnih spremenljivk. Statistično značilne razlike med skupinami ploskev z različno stopnjo poškodovanosti smo ugotovili za šest parametrov: pH-vrednosti in vsebnosti žvepla v organskem delu tal, zastiranje drevesne plasti, zastiranje mahov, število vrst v spodnji drevesni plasti, število vrst zeliščne plasti. Na ploskvah smo prepoznali devet (ter še tri vrste na požarišču zunaj ploskev) invazivnih ali potencialno invazivnih tujerodnih rastlinskih vrst; med drevesnimi sta bila najpogostejša robinija in visoki pajesen. Študija pomembno prispeva k razumevanju razvoja vegetacije, pomlajevanja ključnih drevesnih vrst in poškodb gozdnih tal v inicialni fazi po obsežnem požaru.
Keywords: gozdna vegetacija, poškodbe tal, gozdni požar, drevesne vrste, pestrost vrst, invazivne rastlinske vrste, Kras, Slovenija
Published in DiRROS: 21.05.2024; Views: 135; Downloads: 94
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