171. Zaščita medicinskih sester pri rokovanju s citostatikiAlbina Bobnar, Marija Velepič, Jožica Bostič-Pavlovič, Jožica Urbančič, Tanja Čufer, Olga Cerar, Marjan Bilban, 1998, final research report Keywords: onkologija, medicinske sestre, citostatiki, zaščita osebja
Published in DiRROS: 10.05.2021; Views: 1081; Downloads: 369
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172. Kako premagati izgubo lasMarija Velepič, Jožica Bostič-Pavlovič, Helena Drolc, Tanja Čufer, 1993, other monographs and other completed works Keywords: rak (medicina), bolniki, kemoterapija, radioterapija, izpadanje las, nasveti
Published in DiRROS: 29.04.2021; Views: 1038; Downloads: 324
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173. Kako olajšamo težave ob zdravljenju s kemoterapijoMarija Velepič, Jožica Bostič-Pavlovič, Helena Drolc, Tanja Čufer, 1993, dictionary, encyclopaedia, lexicon, manual, atlas, map Keywords: rak (medicina), kemoterapija, bolniki, nasveti
Published in DiRROS: 29.04.2021; Views: 1006; Downloads: 315
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178. Prognostic impact of PD-1 and PD-L1 expression in malignant pleural mesothelioma : an international multicenter studyLuka Brčić, Thomas Klikovits, Zsolt Megyesfalvi, Berta Mosleh, Katharina Sinn, Richard Hritcu, Viktoria Laszlo, Tanja Čufer, Aleš Rozman, Izidor Kern, Katja Mohorčič, 2021, original scientific article Abstract: Background: Programmed cell death 1/programmed death ligand 1 (PD-1/PD-L1) immune-checkpoint blockade is a promising new therapeutic strategy in cancer. However, expression patterns and prognostic significance of PD-L1 and PD-1 are still controversial in human malignant pleural mesothelioma (MPM). Methods: Formalin-fixed paraffin-embedded (FFPE) tumor samples from 203 MPM patients receiving standard treatment without immunotherapy were collected from 5 European centers. PD-L1 and PD-1 expression of tumor cells (TCs) and tumor-infiltrating lymphocytes (TILs) were measured by immunohistochemistry and correlated with clinical parameters and long-term outcome. Results: High (>10%) PD-L1 TC and PD-1 TILs expressions were found in 18 (8%) and 39 (24%) patients, respectively. PD-L1 was rarely expressed by TILs [>/=1%, n=13 (8%); >10%, n=1]. No significant associations were found between the PD-L1 or PD-1 expression of TCs or TILs and clinicopathological parameters such as stage or histological subtype. Notably, patients with high (>10%) TC-specific PD-L1 expression exhibited significantly worse median overall survival (OS) (6.3 vs. 15.1 months of those with low TC PD-L1 expression; HR: 2.51, P<0.001). In multivariate cox regression analysis adjusted for clinical parameters, high TC PD-L1 expression (>10%) proved to be an independent negative prognostic factor for OS (HR: 2.486, P=0.005). There was no significant correlation between PD-L1 or PD-1 expression of TILs and OS. Conclusions: In this multicenter cohort study, we demonstrate that high (>10%) PD-L1 expression of TCs independently predicts worse OS in MPM. Further studies are warranted to investigate the value of PD-L1/PD-1 expression as a marker for treatment response in MPM patients receiving immunotherapy.
Keywords: mesothelioma - anatomy and histology - analysis, 1malignant pleural mesothelioma, programmed death-ligand 1, programmed cell death 1, PD-L1
Published in DiRROS: 31.03.2021; Views: 1287; Downloads: 554
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179. Pogledi bolnikov in onkologov na uvajanje telemedicine v času epidemije covid-19Miha Oražem, Irena Oblak, Tanja Španić, Ivica Ratoša, 2020, original scientific article Abstract: Izhodišča: Pandemija koronavirusne bolezni 2019 (covid-19) je zaradi epidemioloških ukrepov, zlasti spodbujanja fizične distance, marsikje po svetu pospešila uvajanje telemedicine v klinično prakso. Zato smo želeli pridobiti stališča onkoloških bolnikov in zdravnikov do tovrstne obravnave v onkologiji. Metode: K izpolnjevanju dveh ločenih kvantitativnih vprašal-nikov smo med 27. majem in 11. junijem 2020 prek elektronske pošte ter s pomočjo Slovenskega združenja organizacij bolnikov z rakom (ONKO NET) povabili bolnike z rakom, ki so bili bodisi na aktivnem zdravljenju bodisi na sledenju po zaključenem zdravljenju, in zdravnike onkologe. Dodatno je bil v Sektorju radioterapije Onkološkega inštituta Ljubljana izveden presečni dan za bolnike med obsevanjem. Rezultati: Na spletni ali natisnjen vprašalnik za bolnike je odgovorilo 475 bolnikov, od tega 310 (65,3 %) na aktivnem onko-loškem zdravljenju in 132 (27,8 %) v fazi sledenja. Skoraj polovica bolnikov (48,4 %) je kot primarno diagnozo navedla rak dojk. Več kot desetina vseh (11,3 %) je zaradi pandemije želela opustiti zdravniški pregled. V zasebnem življenju jih pametni telefon ali tablico uporablja 72,4 % in vsaj 30 % bolnikov bi bilo pripravlje-nih v bodoče pogosteje uporabljati telemedicinske storitve. Od 168 povabljenih zdravnikov jih je na vprašalnik odgovoril 101 (60 %) in ocenil, da bi s pomočjo telemedicine lahko opravil 21 % (0%80 %) vseh svojih storitev. Če bi se sami znašli v vlogi bolnika, bi bila prip-ravljena po telemedicini poseči dobra polovica sodelujočih (54,5 %). Zaključki: Uporaba telemedicine v onkologiji bi bila ob upošteva-nju nekaterih omejitev sprejemljiva za pomemben del bolnikov in zdravnikov
Keywords: telemedicina, covid-19, onkologija
Published in DiRROS: 18.03.2021; Views: 1633; Downloads: 437
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180. Zdravljenje raka dojke z obsevanjemTanja Marinko, Marija Snežna Paulin-Košir, Andreja Gojkovič Horvat, Jasenka Gugić Kevo, Danijela Golo, Ivica Ratoša, Maja Ivanetič Pantar, 2020, not set Keywords: bolnice, zdravstveni nasveti
Published in DiRROS: 15.03.2021; Views: 1451; Downloads: 349
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