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Title:Stereotaktična radiokirurgija možganskih zasevkov malignega melanoma
Authors:ID Smrdel, Uroš (Author)
Files:.pdf PDF - Presentation file, download (438,15 KB)
MD5: 3320A70BCD4461453FD8E9DB87709806
Typology:1.04 - Professional Article
Organization:Logo OI - Institute of Oncology
Keywords:stereotaktična radiokirurgija, melanom, možganski zasevki, radiokirurgija
Year of publishing:2013
Publication status in journal:Published
Article version:Publisher's version of article
Number of pages:str. 135-138, 157
Numbering:Letn. 17, št. 2
PID:20.500.12556/DiRROS-8791 New window
ISSN on article:1408-1741
COBISS.SI-ID:1681787 New window
Copyright:by Authors
Publication date in DiRROS:31.08.2018
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Record is a part of a journal

Title:Onkologija : strokovni časopis za zdravnike
Shortened title:Onkologija
Publisher:Onkološki inštitut
COBISS.SI-ID:65324032 New window


License:CC BY 4.0, Creative Commons Attribution 4.0 International
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:31.08.2018

Secondary language

Title:Stereotactic surgery of malignant melanoma brain metastases
Abstract:Since 2007, the Oncology Institute of Ljubljana carried out 97 SRS procedures, 9 of which were performed in patients with malignant melanoma brain metastases. Another patient was treated with hyperfractionated stereotactic radiotherapy (hfSRT), as the irradiated area was too large for irradiation with SRS and, based on the radiobiological characteristics of the tumour, we decided for targeted radiation therapy with a higher daily dose (6). Median survival was 30 weeks for all malignant melanoma patients, with the same survival time until local recurrence of the disease. Following SRS, there were less local recurrences among patients compared to progressions or recurrences of the disease outside the central nervous system (CNS). The irradiation dose delivered to patients treated with SRS was 22.5 Gy (20-25) in a single dose. The patient treated with hfSRT received 30 Gy in total, namely 5 doses of 6 Gy. Eight out of nine patients also received WBRT, and one was treated with WBRT after the first surgery for brain metastases and did not receive it after the SRS. The patient treated with hfSRT due to systemic therapy administered after radiation therapy (vemurafenib) did not receive WBRT and experienced disease progression in the CNS outside the irradiated three months later. The response was achieved in all patients (a stable disease in 4 patients, a partial response in 4 patients, a complete response in 1 patient), with patients with a stable disease experiencing disease progression outside the CNS a few weeks after the therapy. A complete response was achieved in one patient, but six months later, he also experienced disease progression in the CNS outside the SRS area.