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Title:Intratekalna aplikacija trastuzumaba in rituksimaba
Authors:ID Rožman, Samo (Author)
ID Borštnar, Simona (Author)
ID Jezeršek Novaković, Barbara (Author)
Files:.pdf PDF - Presentation file, download (152,68 KB)
MD5: 88AA47A03FD2555F49B5E8D9D1287BD7
PID: 20.500.12556/dirros/63fd768b-0fc4-4175-830b-20715cce7263
 
Language:Slovenian
Typology:1.04 - Professional Article
Organization:Logo OI - Institute of Oncology
Abstract:Neoplastični meningitis je resen zaplet maligne bolezni. Kljub majhni incidenci njegova pogostost narašča, domnevno zaradi daljšega preživetja bolnikov in izboljšane diagnostike. Neoplastični meningitis se zdravi s sistemsko in intratekalno kemoterapijo ter z obsevanjem osrednjega živčevja. Trastuzumab in rituksimab sta monoklonski protitelesi, ki sta ob intravenskih aplikacijah pomembno izboljšali preživetje bolnikov z rakom dojk in Nehodgkinovim limfomom. Manj sta učinkoviti pri zdravljenju neoplastičnega meningitisa, saj zaradi velikosti ne prehajata krvno-možganske pregrade. Novejše raziskave preučujejo tudi možnost intratekalne aplikacije monoklonskih protiteles.
Keywords:onkologija, neoplastični meningitis, zdravljenje
Publication status:Published
Publication version:Version of Record
Year of publishing:2011
Number of pages:str. 39-42
Numbering:Letn. 15, št. 1
PID:20.500.12556/DiRROS-8713 New window
UDC:616.831-006.6-08
ISSN on article:1408-1741
URN:URN:NBN:SI:doc-64L1Y4F1
COBISS.SI-ID:1132411 New window
Copyright:by Authors
Publication date in DiRROS:31.08.2018
Views:2896
Downloads:757
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Record is a part of a journal

Title:Onkologija. strokovni časopis za zdravnike
Shortened title:Onkologija
Publisher:Onkološki inštitut
ISSN:1408-1741
COBISS.SI-ID:65324032 New window

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:31.08.2018

Secondary language

Language:English
Title:Intrathecal Administration of trastuzumab and rituximab
Abstract:Neoplastic meningitis is a serious complication of malignant disease. In spite of low incidence, its frequency is increasing. This is believed to be due to better cancer patient survival and improved diagnostic procedures. Treatment of neoplastic meningitis usually consists of systemic and intrathecal therapy along with radiotherapy of central nervous system. Trastuzumab and rituximab are monoclonal antibodies that significantly improved the outcome of breast cancer and nonHodgkin lymphoma patients. While the two monoclonal antibodies are effective agents for their respective disease states, their efficacy is poor in the treatment of neoplastic meningitis as they are unable to cross the blood-brain barrier. This is a review of evidence for the potential use of intrathecal trastuzumab and rituximab.


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