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Title:Neželeni učinki zdravil za sistemsko zdravljenje raka na koži
Authors:ID Ocvirk, Janja (Author)
Files:.pdf PDF - Presentation file, download (464,82 KB)
MD5: 64FD0ECAEA1659B90AE6D1077E19C4BB
PID: 20.500.12556/dirros/4f8f0481-c58d-443d-ba38-255bbf5d77bf
 
Language:Slovenian
Typology:1.04 - Professional Article
Organization:Logo OI - Institute of Oncology
Abstract:Zdravljenje s citostatiki povzroča številne neželene učinke, med katerimi jih kar nekaj prizadene tudi kožo in sluznice, saj so v njih celice, ki se hitro delijo in prav na te celice citostatiki najmočneje vplivajo. Kožna toksičnost se ob zdravljenju s citostatiki lahko izraža kot sindrom roka – noga, dermatitis, eksantem, eritroderma, hiperpigmentacija. Paleta neželenih učinkov na kožo pri uporabi tarčnih zdravil pa je razen sindroma roka – noga ob multitarčnih zdravilih nekoliko drugačna. Pri uporabi zaviralcev EGFR je pogosto izražena kožna toksičnost, najpogosteje akniformni izpuščaj. Kseroze, ekceme, poke kože, teleangiektazije, spremembe nohtov in paronihijo opažamo pri nekaterih bolnikih, hiperpigmentacije kože pa so redkejše. Obvladovanje kožnih sprememb pomaga bolnikom prebroditi neželene učinke, pri čemer je izredno pomembno sodelovanje bolnikov. Kožna toksičnost je navadno obvladljiva s topično ali sistemsko uporabo zdravil, včasih pa je treba zmanjšati odmerek citostatika ali tarčnega zdravila oz. prilagoditi shemo zdravljenja. Poduk bolnikov pred zdravljenjem in hitro ukrepanje ob prvih znakih kožne toksičnosti sta ključna za uspeh.
Publication status:Published
Publication version:Version of Record
Year of publishing:2009
Number of pages:str. 37-40
Numbering:Letn. 13, št. 1
PID:20.500.12556/DiRROS-8621 New window
UDC:616-006
ISSN on article:1408-1741
URN:URN:NBN:SI:doc-9VNU6JK8
COBISS.SI-ID:25705433 New window
Copyright:by Authors
Note:BSDOCID145253;
Publication date in DiRROS:31.08.2018
Views:3649
Downloads:768
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Record is a part of a journal

Title:Onkologija
Shortened title:Onkologija
Publisher:Onkološki inštitut
ISSN:1408-1741
COBISS.SI-ID:65324032 New window

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:31.08.2018

Secondary language

Language:English
Title:Cytostatic and Targeted Drug-Induced Skin Toxicities
Abstract:The patients treated with cytostatic drugs may experience many side-effects, among them also skin and mucosal side-effects because skin and mucosal cells rapidly divide and are therefore most sensitive to cytostatics. The most common skin side-effects are hand-foot syndrome, eczema, erythroderma, hyperpigmentation. Skin toxicity of targeted drugs is different with the exception of hand-foot syndrome. EGFR-inhibitors often cause skin toxicity, most frequently acneiform eruption. Xerosis, eczema, fissures, teleangiectasias, nail changes and paronychia can be seen in some cases, rarely hyperpigmentation. Management of the skin toxicity helps patients to overcome cytostatics- and EGFR- inhibitors associated skin toxicity and is of great importance for patients’ compliance. It is generally manageable with standard topical or systemic antibiotics and anti-inflammatory agents; In some cases, it is nevertheless necessary to reduce doses of the drugs. Education of patients prior to beginning the therapy and proactive intervention at the first signs of skin toxicity are keys to successful management.


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