Lynparza (olaparib) : novo tarčno zdravilo pri raku jajčnikov

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Title:	Lynparza (olaparib) : novo tarčno zdravilo pri raku jajčnikov
Authors:	ID Škof, Erik (Author) ID Krajc, Mateja (Author)
Files:	PDF - Presentation file, download (455,09 KB) MD5: 37B328CD7E07A7A79800651CD6B55CD1 PID: 20.500.12556/dirros/0a8348db-a511-405e-9e78-3dea12aebdba
Language:	Slovenian
Typology:	1.04 - Professional Article
Organization:	OI - Institute of Oncology
Keywords:	rak jajčnikov, tarčna zdravila, kemoterapija, dedni raki
Publication status:	Published
Publication version:	Version of Record
Year of publishing:	2016
Number of pages:	str. 12-14
Numbering:	Letn. 20, št. 1
PID:	20.500.12556/DiRROS-8145
UDC:	618.1
ISSN on article:	1408-1741
COBISS.SI-ID:	2416763
Copyright:	by Authors
Publication date in DiRROS:	03.01.2018
Views:	3910
Downloads:	908
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Title:	Onkologija. strokovni časopis za zdravnike
Shortened title:	Onkologija
Publisher:	Onkološki inštitut
ISSN:	1408-1741
COBISS.SI-ID:	65324032

License:	CC BY 4.0, Creative Commons Attribution 4.0 International

Link:	http://creativecommons.org/licenses/by/4.0/
Description:	This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:	03.01.2018

Language:	English
Title:	Lynparza (olaparib) : New Mmedicine for targeted therapy of ovarian cancer
Abstract:	A new medicine for targeted treatment of patients with recurring serous ovarian or primary peritoneal serous carcinoma (PPSC), who have a mutation of BRCA1/2 genes (somatic mutation), was recently registered in the EU – LynparzaTM (olaparib). Olaparib was registered based on a subanalysis of a study in phase II (9), in which patients with BRCA1/2 gene mutation who received olaparib lived 7 months longer without the disease progressing than patients that were not administered this medicine (11 months vs. 4 months); the difference was statistically relevant (HR 0.18; p < 0.00001). There were no differences in total survival of patients. Olaparib is an oral medication in capsules, so patients can take it at home. The available data shows that the most frequent side effects were nausea and fatigue. 25% of patients took olaparib for two years or more and the therapy was rarely discontinued due to side effects (only 9% of patients), which shows that patients usually tolerate olaparib well, which is a great advantage compared to chemotherapy, which was so far the only available treatment for recurring ovarian cancer (9).