| Title: | Post-polymerization modification of poly(L-glutamic acid) with d-(+)-glucosamine |
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| Authors: | ID Perdih, Peter (Author)
ID Čebašek, Sašo (Author)
ID Možir, Alenka (Author)
ID Žagar, Ema (Author) |
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| Files: |  URL - Presentation file, visit http://www.mdpi.com/1420-3049/19/12/19751
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  KI - National Institute of Chemistry
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| Abstract: | Carboxyl functional groups of poly(L-glutamic acid) (PGlu) were modified with
a D-(+)-glucosamine (GlcN) by amidation using 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-
methylmorpholinium chloride (DMTMM) as a coupling reagent. The coupling reaction
was performed in aqueous medium without protection of hydroxyl functional groups of
D-(+)-glucosamine. Poly(L-glutamic acid) and GlcN functionalized polyglutamates
(P(Glu-GlcN)) were thoroughly characterized by 1D and 2D NMR spectroscopy and
SEC-MALS to gain detailed information on their structure, composition and molar mass
characteristics. The results reveal successful functionalization with GlcN through the
amide bond and also to a minor extent through ester bond formation in position 1 of GlcN.
In addition, a ratio between the α- and β-form of glucosamine substituent coupled to
polyglutamate repeating units as well as the content of residual dimethoxy triazinyl active
ester moiety in the samples were evaluated. |
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| Keywords: | poly(L-glutamic acid), glucosamine, glycopolypeptide |
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| Publication status: | Published |
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| Year of publishing: | 2014 |
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| Number of pages: | str. 19751-19768 |
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| Numbering: | Vol. 19, iss. 12 |
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| PID: | 20.500.12556/DiRROS-755  |
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| UDC: | 620.1/.2 |
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| ISSN on article: | 1420-3049 |
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| DOI: | 10.3390/molecules191219751 |
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| COBISS.SI-ID: | 5609754 |
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| Note: | Sodelavci: Sašo Čebašek, Alenka Možir and Ema Žagar;
Nasl. z nasl. zaslona;
Opis vira z dne 1. 12. 2014; |
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| Publication date in DiRROS: | 16.12.2014 |
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| Views: | 5036 |
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| Downloads: | 1031 |
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