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Title:Post-polymerization modification of poly(L-glutamic acid) with d-(+)-glucosamine
Authors:ID Perdih, Peter (Author)
ID Čebašek, Sašo (Author)
ID Možir, Alenka (Author)
ID Žagar, Ema (Author)
Files:URL URL - Presentation file, visit
Typology:1.01 - Original Scientific Article
Organization:Logo KI - National Institute of Chemistry
Abstract:Carboxyl functional groups of poly(L-glutamic acid) (PGlu) were modified with a D-(+)-glucosamine (GlcN) by amidation using 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4- methylmorpholinium chloride (DMTMM) as a coupling reagent. The coupling reaction was performed in aqueous medium without protection of hydroxyl functional groups of D-(+)-glucosamine. Poly(L-glutamic acid) and GlcN functionalized polyglutamates (P(Glu-GlcN)) were thoroughly characterized by 1D and 2D NMR spectroscopy and SEC-MALS to gain detailed information on their structure, composition and molar mass characteristics. The results reveal successful functionalization with GlcN through the amide bond and also to a minor extent through ester bond formation in position 1 of GlcN. In addition, a ratio between the α- and β-form of glucosamine substituent coupled to polyglutamate repeating units as well as the content of residual dimethoxy triazinyl active ester moiety in the samples were evaluated.
Keywords:poly(L-glutamic acid), glucosamine, glycopolypeptide
Publication status in journal:Published
Year of publishing:2014
Number of pages:str. 19751-19768
Numbering:Vol. 19, iss. 12
PID:20.500.12556/DiRROS-755 New window
ISSN on article:1420-3049
DOI:10.3390/molecules191219751 New window
COBISS.SI-ID:5609754 New window
Note:Sodelavci: Sašo Čebašek, Alenka Možir and Ema Žagar; Nasl. z nasl. zaslona; Opis vira z dne 1. 12. 2014;
Publication date in DiRROS:16.12.2014
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Shortened title:Molecules
COBISS.SI-ID:18462981 New window

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Keywords:materiali, polimerizacija, struktura snovi