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Title:Design principles for rapid folding of knotted DNA nanostructures
Authors:Kočar, Vid (Author)
Schreck, John S. (Author)
Čeru, Slavko (Author)
Gradišar, Helena (Author)
Bašić, Nino (Author)
Pisanski, Tomaž (Author)
Doye, Jonathan P. K. (Author)
Jerala, Roman (Author)
Language:English
Tipology:1.01 - Original Scientific Article
Organisation:Logo KI - National Institute of Chemistry
Abstract:Knots are some of the most remarkable topological features in nature. Self-assembly of knotted polymers without breaking or forming covalent bonds is challenging, as the chain needs to be threaded through previously formed loops in an exactly defined order. Here we describe principles to guide the folding of highly knotted single-chain DNA nanostructures as demonstrated on a nano-sized square pyramid. Folding of knots is encoded by the arrangement of modules of different stability based on derived topological and kinetic rules. Among DNA designs composed of the same modules and encoding the same topology, only the one with the folding pathway designed according to the "free-end" rule folds efficiently into the target structure. Besides high folding yield on slow annealing, this design also folds rapidly on temperature quenching and dilution from chemical denaturant. This strategy could be used to design folding of other knotted programmable polymers such as RNA or proteins.
Year of publishing:2016
COBISS_ID:5880858 Link is opened in a new window
UDC:577.2
ISSN on article:2041-1723
OceCobissID:2315876 Link is opened in a new window
DOI:10.1038/ncomms10803 Link is opened in a new window
Note:Sodelavci: John S. Schreck, Slavko Čeru, Helena Gradišar, Nino Bašić, Tomaž Pisanski, Jonathan P. K. Doye & Roman Jerala; Opis vira z dne 7. 3. 2016; Nasl. z nasl. zaslona; Št. članka 10803;
Views:3621
Downloads:978
Files:URL URL - Presentation file, visit http://dx.doi.org/10.1038/ncomms10803
 
Journal:Nature communications
Nature Publishing Group
 
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Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:13.04.2016

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