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Title:Design principles for rapid folding of knotted DNA nanostructures
Authors:ID Kočar, Vid (Author)
ID Schreck, John S. (Author)
ID Čeru, Slavko (Author)
ID Gradišar, Helena (Author)
ID Bašić, Nino (Author)
ID Pisanski, Tomaž (Author)
ID Doye, Jonathan P. K. (Author)
ID Jerala, Roman (Author)
Files:.pdf PDF - Presentation file, download (1,70 MB)
MD5: 1DAE78AF2A52BB0131C29E726A2241E9
PID: 20.500.12556/dirros/5b23d4fd-014f-4351-8361-2e98365fbd10
URL URL - Source URL, visit
Typology:1.01 - Original Scientific Article
Organization:Logo KI - National Institute of Chemistry
Abstract:Knots are some of the most remarkable topological features in nature. Self-assembly of knotted polymers without breaking or forming covalent bonds is challenging, as the chain needs to be threaded through previously formed loops in an exactly defined order. Here we describe principles to guide the folding of highly knotted single-chain DNA nanostructures as demonstrated on a nano-sized square pyramid. Folding of knots is encoded by the arrangement of modules of different stability based on derived topological and kinetic rules. Among DNA designs composed of the same modules and encoding the same topology, only the one with the folding pathway designed according to the "free-end" rule folds efficiently into the target structure. Besides high folding yield on slow annealing, this design also folds rapidly on temperature quenching and dilution from chemical denaturant. This strategy could be used to design folding of other knotted programmable polymers such as RNA or proteins.
Publication status in journal:Published
Article version:Publisher's version of article
Year of publishing:2016
Number of pages:str. 1-8
Numbering:Vol. 7
PID:20.500.12556/DiRROS-5622 New window
ISSN on article:2041-1723
DOI:10.1038/ncomms10803 New window
COBISS.SI-ID:5880858 New window
Note:Sodelavci: John S. Schreck, Slavko Čeru, Helena Gradišar, Nino Bašić, Tomaž Pisanski, Jonathan P. K. Doye & Roman Jerala; Opis vira z dne 7. 3. 2016; Nasl. z nasl. zaslona; Št. članka 10803;
Publication date in DiRROS:13.04.2016
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Record is a part of a journal

Title:Nature communications
Publisher:Nature Publishing Group
COBISS.SI-ID:2315876 New window


License:CC BY 4.0, Creative Commons Attribution 4.0 International
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:13.04.2016

Secondary language

Keywords:biokemija, DNA, nanostrukture, struktura snovi