| Title: | Giant cutaneous melanoma presenting with hemorrhagic complications |
|---|
| Authors: | ID Lovšin, Klemen (Author)
ID Plesničar, Ana (Author)
ID Cencelj-Arnež, Romi (Author)
ID Matjašič, Alenka (Author)
ID Luzar, Boštjan (Author) |
|---|
| Files: |  PDF - Presentation file, download (26,61 MB)
MD5: 20ADCDD157EB6A4083BF813C9A257552
 URL - Source URL, visit https://acta-apa.mf.uni-lj.si/journals/acta-dermatovenerol-apa/papers/10.15570/actaapa.2026.1/actaapa.2026.1.pdf
|
|---|
| Language: | English |
|---|
| Typology: | 1.03 - Other scientific articles |
|---|
| Organization: |  ZSD - Association of Slovenian Dermatovenereologists
 UKC LJ - Ljubljana University Medical Centre
|
|---|
| Abstract: | Giant cutaneous melanoma is a rare presentation characterized by significant morbidity and mortality. We report the case of a 45-year-old male presenting with an acute life-threatening hemorrhage from a giant melanoma on his right thigh. The tumor, measuring 90 × 50 × 85 mm, was immediately excised under local anesthesia to achieve hemostasis. The patient exhibited acute anemia and required postoperative blood transfusion. Histopathological analysis confirmed superficial spreading melanoma with a Breslow thickness of 85.0 mm and extensive ulceration. Genetic testing identified critical mutations, including BRAFV600D and alterations involving the ARID2, CDKN2A/B, AKT3, PTEN, and HRAS genes. Remarkably, no metastatic disease was detected upon thorough diagnostic evaluation. The patient received adjuvant immunotherapy with programmed cell death-1 inhibitors. Six months after the procedure, he remains free of metastasis. This case underscores the urgent need for timely recognition and intervention in giant melanoma with acute complications. It also highlights the effectiveness of modern adjuvant therapies in improving prognosis. |
|---|
| Keywords: | dermatologic surgery, dermatopathology, melanoma, skin cancer |
|---|
| Publication status: | Published |
|---|
| Publication version: | Version of Record |
|---|
| Submitted for review: | 02.04.2025 |
|---|
| Article acceptance date: | 02.07.2025 |
|---|
| Publication date: | 01.03.2026 |
|---|
| Place of publishing: | Ljubljana |
|---|
| Publisher: | Združenje slovenskih dermatovenerologov |
|---|
| Year of publishing: | 2026 |
|---|
| Number of pages: | str. 129-132 |
|---|
| Numbering: | Vol. 35, iss. 2 |
|---|
| PID: | 20.500.12556/DiRROS-30772  |
|---|
| UDC: | 617 |
|---|
| ISSN on article: | 1318-4458 |
|---|
| DOI: | 10.15570/actaapa.2026.1 |
|---|
| COBISS.SI-ID: | 283158531 |
|---|
| Copyright: | Na spletni strani revije navedeno: Acta Dermatovenerologica Alpina, Pannonica et Adriatica (ISSN 1318-4458) is an open access medical journal published quarterly by the Association of Slovenian Dermatovenerologists (https://acta-apa.mf.uni-lj.si/index.php); Authors publishing in our journal retain copyright of their work under the Creative Commons Attribution License (CC BY 4.0). This license allows unrestricted use, distribution, and reproduction of the work in any medium, provided the original author(s) and copyright holder(s) are appropriately credited, and the original publication in the journal is properly cited, following established academic practices (https://acta-apa.mf.uni-lj.si/submissions.php). |
|---|
| Note: | Soavtorji: Ana Plesničar, Romi Cencelj-Arnež, Alenka Matjašič, Boštjan Luzar; |
|---|
| Publication date in DiRROS: | 02.07.2026 |
|---|
| Views: | 201 |
|---|
| Downloads: | 144 |
|---|
| Metadata: |    |
|---|
|
:
|
Copy citation |
|---|
| | | | Share: |  |
|---|
Hover the mouse pointer over a document title to show the abstract or click
on the title to get all document metadata. |
