| Title: | Influence of nutritional status and body composition on postoperative events and outcome in patients treated for primary localized retroperitoneal sarcoma |
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| Authors: | ID Ramanović, Manuel (Author)
ID Novak, Marko (Author)
ID Perhavec, Andraž (Author)
ID Jordan, Taja (Author)
ID Popuri, Karteek (Author)
ID Rotovnik-Kozjek, Nada (Author) |
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| Files: |  PDF - Presentation file, download (1,02 MB)
MD5: D962E2547D2DA750A37E00D6C22BC04D
PDF - Presentation file, download (1,00 MB)
MD5: 2262D6FB52465D7F8F984064699F6E48
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  DRO - Association of Radiology and Oncology
 OI - Institute of Oncology
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| Abstract: | Background: Retroperitoneal sarcomas (RPS) are rare tumours of mesenchymal origin, commonly presented as a large tumour mass at time of diagnosis. We investigated the impact of body composition on outcome in patients operated on for primary localized RPS. Patients and methods: We retrospectively analysed data for all patients operated on for primary RPS at our institution between 1999 and 2020. Preoperative skeletal muscle area (SMA), visceral and subcutaneous adipose tissue area (VAT and SAT) and muscle radiation attenuation (MRA) were calculated using computed tomography scans at the level of third lumbar vertebra. European Working Group on Sarcopenia in Older People (EWGSOP2) criteria were applied to define myopenia. Using maximum log-rank statistic method we determined the optimal cut-off values of body composition parameters. Myosteatosis was defined based on determined MRA cut-offs. Results: In total 58 patient were eligible for the study. With a median follow-up of 116 months, the estimated 5-year overall survival (OS) and local-recurrence free survival (LRFS) were 66.8% and 77.6%, respectively. Patients with myopenia had significantly lower 5-year OS compared to non-myopenic (p = 0.009). Skeletal muscle index and subcutaneous adipose tissue index predicted LRFS on univariate analysis (p = 0.052 and p = 0.039, respectively). In multivariate analysis high visceral-to-subcutaneous adipose tissue area ratio (VSR) independently predicted higher postoperative complication rate (89.2% vs. 10.8%, p = 0.008). Myosteatosis was associated with higher postoperative morbidity. Conclusions: Myopenia affected survival, but not postoperative outcome in RPS. Visceral obesity, VSR (> 0.26) and myosteatosis were associated with higher postoperative morbidity. VSR was better prognostic factor than VAT in RPS. |
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| Keywords: | body composition, cancer cachexia, obesity |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Publication date: | 01.03.2024 |
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| Publisher: | Association of Radiology and Oncology |
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| Year of publishing: | 2024 |
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| Number of pages: | str. 110-123, XI |
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| Numbering: | Vol. 58, no. 1 |
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| Source: | Ljubljana |
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| PID: | 20.500.12556/DiRROS-30452  |
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| UDC: | 616-006 |
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| ISSN on article: | 1318-2099 |
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| DOI: | 10.2478/raon-2024-0013 |
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| COBISS.SI-ID: | 187614467 |
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| Publication date in DiRROS: | 26.06.2026 |
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| Views: | 56 |
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| Downloads: | 44 |
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