| Title: | Development of and adherence to artificial gravity and resistive vibration exercises during 60 days of hypoxic 6° head-down tilt bed rest : BRAVE study |
|---|
| Authors: | ID Fortune, Jack, Institut "Jožef Stefan" (Author)
ID Sorrentino, Riccardo, Institut "Jožef Stefan" (Author)
ID Zamantzas, Spyridon, Institut "Jožef Stefan" (Author)
ID Faivre-Rampant, Victorien, Institut "Jožef Stefan" (Author)
ID Tsoutsoubi, Lydia, Institut "Jožef Stefan" (Author)
ID McDonnell, Adam, Institut "Jožef Stefan" (Author)
ID Fisher, Jason T., Institut "Jožef Stefan" (Author)
ID Podgornik, Sara, Institut "Jožef Stefan" (Author)
ID Ioannou, Leonidas G., Institut "Jožef Stefan" (Author)
ID Ciuha, Urša, Institut "Jožef Stefan" (Author)
ID Mekjavić, Igor B., Institut "Jožef Stefan" (Author) |
|---|
| Files: |  URL - Source URL, visit https://physoc.onlinelibrary.wiley.com/doi/10.1113/EP093699
 PDF - Presentation file, download (1,73 MB)
MD5: 9FD5FB233E7AF74321D146858D23BA05
|
|---|
| Language: | English |
|---|
| Typology: | 1.01 - Original Scientific Article |
|---|
| Organization: |  IJS - Jožef Stefan Institute
|
|---|
| Abstract: | Artificial gravity (AG) combined with resistive vibration exercise has been proposed as a multi-system countermeasure for long-duration spaceflight; however, its operational feasibility during prolonged unloading remains insufficiently characterised. This study primarily evaluated the feasibility, tolerability, and adherence to a structured resistive vibration exercise protocol delivered either under artificial gravity (AGRVE) or in horizontal loading (HRVE) during 60 days of hypoxic (F[sub](IO2) = 0.14) 6° head-down tilt bed rest. Secondary observations included delayed-onset muscle soreness (DOMS) and changes in eight-repetition maximum strength (8RM) to inform load progression. Sixteen healthy male participants were allocated to HRVE (n = 9) or AGRVE (n = 8) and completed near-daily 30-min training sessions at light (30% 1RM) and moderate (50% 1RM) intensities. Adherence was high in both groups (HRVE: 98.5%; AGRVE: 96.3%). In AGRVE, early-session interruptions were primarily due to motion sickness or presyncopal symptoms; motion sickness severity declined significantly across repeated centrifugation exposures (P < 0.001), consistent with vestibular habituation. HRVE interruptions were predominantly fatigue-related. DOMS remained low throughout the intervention (typically 0–3/10). 8RM increased over time in both groups (P < 0.001). Progressive resistive vibration exercise can be implemented with high adherence during prolonged hypoxic bed rest, including when combined with AG. Motion sickness represents the principal early operational constraint specific to squat-based AG exposure but diminishes with repeated sessions. |
|---|
| Keywords: | artificial gravity, resistive vibration exercise, exercise physiology |
|---|
| Publication status: | Published |
|---|
| Publication version: | Version of Record |
|---|
| Submitted for review: | 23.01.2026 |
|---|
| Article acceptance date: | 09.03.2026 |
|---|
| Publication date: | 28.05.2026 |
|---|
| Publisher: | Published by John Wiley & Sons Ltd on behalf of The Physiological Society. |
|---|
| Year of publishing: | 2026 |
|---|
| Number of pages: | str. 1-21 |
|---|
| Numbering: | Vol. 111, iss. |
|---|
| PID: | 20.500.12556/DiRROS-30213  |
|---|
| UDC: | 612 |
|---|
| ISSN on article: | 1469-445X |
|---|
| DOI: | 10.1113/EP093699 |
|---|
| COBISS.SI-ID: | 281903875 |
|---|
| Copyright: | © The Author(s). |
|---|
| Note: | Nasl. z nasl. zaslona;
Soavtorji iz Slovenije: Sara Podgornik, Urša Ciuha, Igor B. Mekjavič;
Opis vira z dne 17. 6. 2026;
|
|---|
| Publication date in DiRROS: | 17.06.2026 |
|---|
| Views: | 45 |
|---|
| Downloads: | 30 |
|---|
| Metadata: |    |
|---|
|
:
|
Copy citation |
|---|
| | | | Share: |  |
|---|
Hover the mouse pointer over a document title to show the abstract or click
on the title to get all document metadata. |
