| Title: | Associations of PFAS and phthalate/DINCH metabolites with metabolic regulation in teenagers from the HBM4EU aligned studies |
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| Authors: | ID Rodríguez-Carillo, Andrea (Author)
ID Cox, Bianca (Author)
ID Hassen, Hamid Y. (Author)
ID Govarts, Eva (Author)
ID Kosjek, Tina, Institut "Jožef Stefan" (Author)
ID Tkalec, Žiga, Institut "Jožef Stefan" (Author)
ID Remy, Sylvie (Author), et al. |
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| Files: |  URL - Source URL, visit https://www.sciencedirect.com/science/article/pii/S0160412026002606
 PDF - Presentation file, download (3,02 MB)
MD5: 37B731836B20EB08230686B1189493CE
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  IJS - Jožef Stefan Institute
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| Abstract: | Background. Exposure to per- and polyfluoroalkyl substances (PFAS) and phthalates is widespread during adolescence, a critical developmental period for metabolic regulation. Aim. To assess associations of serum PFAS and urinary phthalate/DINCH metabolites-individually and as mixtures-with a unified panel of metabolic biomarkers representing adipose-brain-liver cross-talk and oxidative stress in European teenagers. Methodology. Serum PFAS and urinary phthalate/DINCH metabolites were measured in 1033 European teenagers (12–17 years) from the Human Biomonitoring Initiative for Europe (HBM4EU) Aligned Studies. Metabolic biomarkers representing adipose (HDL, LDL, cholesterol, and triglycerides)-brain (leptin, adiponectin, and kisspeptin)–liver (glucose, insulin) cross-talk and oxidative stress (8-hydroxy-2′-deoxyguanosine, 8OHdG) were measured. The Body Mass Index z-score (zBMI) was calculated. Single pollutant models, multivariate MANOVA, quantile g-computation, and BKMR models were fit, including interaction terms with sex. Results. Single pollutant models showed positive associations of PFAS and phthalate/DINCH metabolites with 8OHdG. PFAS were associated with higher leptin, HDL, LDL, and cholesterol, while some phthalate/DINCH metabolites were associated with lower kisspeptin, HDL, triglycerides, cholesterol, zBMI, and higher adiponectin. We observed weak but statistically significant associations between PFAS and phthalate/DINCH metabolites with the entire set of metabolic biomarkers in the MANOVA. The PFAS mixture was associated with higher kisspeptin, LDL, HDL, cholesterol, and 8OHdG. The phthalate/DINCH mixture was associated with lower HDL. Conclusions. Exposure to these contaminants may be related to dyslipidemia in teenagers. PFAS and phthalate/DINCH metabolites may exert opposite associations on metabolism, with the exception of increasing oxidative stress. Given the cross‑sectional design and potential residual confounding, longitudinal studies are warranted. |
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| Keywords: | human biomonitoring, DINCH metabolites, HBM4EU, metabolic regulation, perfluoroalkyl substances, polyfluoroalkyl substances |
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| Geographic coverage: | Evropska unija; |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Submitted for review: | 16.01.2026 |
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| Article acceptance date: | 12.05.2026 |
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| Publication date: | 18.05.2026 |
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| Publisher: | Elsevier |
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| Year of publishing: | 2026 |
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| Number of pages: | str. [1-36] |
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| Numbering: | Vol. , article no. 110302 |
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| Source: | Nizozemska |
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| PID: | 20.500.12556/DiRROS-30185  |
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| UDC: | 504.5 |
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| ISSN on article: | 1873-6750 |
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| DOI: | 10.1016/j.envint.2026.110302 |
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| COBISS.SI-ID: | 278295043 |
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| Copyright: | © 2026 The Author(s). |
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| Note: | Nasl. z nasl. zaslona;
Soavtorja iz Slovenije: Tina Kosjek, Žiga Tkalec;
Opis vira z dne 15. 5. 2026;
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| Publication date in DiRROS: | 16.06.2026 |
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| Views: | 38 |
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| Downloads: | 17 |
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