| Title: | Psychometric evaluation of the 5-item Medication Adherence Report Scale questionnaire in persons with multiple sclerosis |
|---|
| Authors: | ID Jožef, Maj (Author)
ID Locatelli, Igor (Author)
ID Brecl Jakob, Gregor (Author)
ID Savšek, Lina (Author)
ID Šurlan Popović, Katarina (Author)
ID Špiclin, Žiga (Author)
ID Rot, Uroš (Author)
ID Kos, Mitja (Author) |
|---|
| Files: |  PDF - Presentation file, download (627,65 KB)
MD5: 8B71448B2C430C225890074C8E89F223
 URL - Source URL, visit https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0294116
|
|---|
| Language: | English |
|---|
| Typology: | 1.01 - Original Scientific Article |
|---|
| Organization: |  UKC LJ - Ljubljana University Medical Centre
|
|---|
| Abstract: | The 5-item Medication Adherence Report Scale (MARS-5) is a reliable and valid questionnaire for evaluating adherence in patients with asthma, hypertension, and diabetes. Validity has not been determined in multiple sclerosis (MS). We aimed to establish criterion validity and reliability of the MARS-5 in persons with MS (PwMS). Our prospective study included PwMS on dimethyl fumarate (DMF). PwMS self-completed the MARS-5 on the same day before baseline and follow-up brain magnetic resonance imaging (MRI) 3 and 9 months after treatment initiation and were graded as highly and medium adherent upon the 24-cutoff score, established by receiver operator curve analysis. Health outcomes were represented by relapse occurrence from the 1st DMF dispense till follow-up brain MRI and radiological progression (new T2 MRI lesions and quantitative analysis) between baseline and follow-up MRI. Criterion validity was established by association with the Proportion of Days Covered (PDC), new T2 MRI lesions, and Beliefs in Medicines questionnaire (BMQ). The reliability evaluation included internal consistency and the test-retest method. We included 40 PwMS (age 37.6 ± 9.9 years, 75% women), 34 were treatment-naive. No relapses were seen during the follow-up period but quantitative MRI analysis showed new T2 lesions in 6 PwMS. The mean (SD) MARS-5 score was 23.1 (2.5), with 24 PwMS graded as highly adherent. The higher MARS-5 score was associated with higher PDC (b = 0.027, P<0.001, 95% CI: (0.0134–0.0403)) and lower medication concerns (b = -1.25, P<0.001, 95% CI: (-1.93-(-0,579)). Lower adherence was associated with increased number (P = 0.00148) and total volume of new T2 MRI lesions (P = 0.00149). The questionnaire showed acceptable internal consistency (Cronbach α = 0.72) and moderate test-retest reliability (r = 0.62, P < 0.0001, 95% CI: 0.33–0.79). The MARS-5 was found to be valid and reliable for estimating medication adherence and predicting medication concerns in persons with MS. |
|---|
| Keywords: | Medication Adherence Report Scale (MARS-5), dimethyl fumarate, multiple sclerosis, new T2 MRI lesions, Proportion of Days Covered (PDC), Beliefs in Medicines questionnaire (BMQ), validation, consistency, test-retest |
|---|
| Publication status: | Published |
|---|
| Publication version: | Version of Record |
|---|
| Year of publishing: | 2024 |
|---|
| Number of pages: | 13 str. |
|---|
| Numbering: | Vol. 19, issue 3, [article no.] e0294116 |
|---|
| PID: | 20.500.12556/DiRROS-30166  |
|---|
| UDC: | 616.832-004 |
|---|
| ISSN on article: | 1932-6203 |
|---|
| DOI: | 10.1371/journal.pone.0294116 |
|---|
| COBISS.SI-ID: | 188641539 |
|---|
| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 13. 3. 2024;
|
|---|
| Publication date in DiRROS: | 16.06.2026 |
|---|
| Views: | 36 |
|---|
| Downloads: | 17 |
|---|
| Metadata: |    |
|---|
|
:
|
Copy citation |
|---|
| | | | Share: |  |
|---|
Hover the mouse pointer over a document title to show the abstract or click
on the title to get all document metadata. |
